2. Metabolic Enzyme/Protease
  3. Acyltransferase
  4. Fumonisin B2

Fumonisin B2, a mycotoxin produced by Fusarium moniliforme in various grains, is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis.

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Fumonisin B2 Chemical Structure

Fumonisin B2 Chemical Structure

CAS No. : 116355-84-1

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Based on 1 publication(s) in Google Scholar

Other Forms of Fumonisin B2:

Fumonisin B2 Related Antibodies

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ACAT1 ACAT2 MGAT2 ACAT

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Description

Fumonisin B2, a mycotoxin produced by Fusarium moniliforme in various grains, is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis[1][2].

IC50 & Target

Sphingosine N-acyltransferase[2]
Molecular Weight

705.83

Formula

C34H59NO14
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

OC(C[C@@H](C(O)=O)CC(O[C@@H](C[C@@H](C)CCCCCC[C@@H](O)C[C@H](O)[C@@H](N)C)[C@@H]([C@H](C)CCCC)OC(C[C@H](C(O)=O)CC(O)=O)=O)=O)=O
Structure Classification
Initial Source

Aspergillus niger
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

PBS : 15 mg/mL (21.25 mM; ultrasonic and warming and adjust pH to 7.2)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4168 mL 7.0839 mL 14.1677 mL
5 mM 0.2834 mL 1.4168 mL 2.8335 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
PBS 1 mM 1.4168 mL 7.0839 mL 14.1677 mL 35.4193 mL
5 mM 0.2834 mL 1.4168 mL 2.8335 mL 7.0839 mL
10 mM 0.1417 mL 0.7084 mL 1.4168 mL 3.5419 mL
15 mM 0.0945 mL 0.4723 mL 0.9445 mL 2.3613 mL
20 mM 0.0708 mL 0.3542 mL 0.7084 mL 1.7710 mL
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Fumonisin B2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fumonisin B2116355-84-1Fumonisin B 2Fumonisin B-2AcyltransferaseDiacylglycerol acyltransferaseDiglyceride acyltransferaseacyl-CoA:cholesterol acyltransferasemono- acylglycerol acyltransferaseInhibitorinhibitorinhibit

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