Search Result
Results for "
Fungus
" in MedChemExpress (MCE) Product Catalog:
5
Biochemical Assay Reagents
4
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-N10235
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- HY-N9378
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Fungal
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Infection
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3-Oxobetulin, an antifungal agent, shows antifungal activities against white rot fungus L. betulina and the brown rot fungus L. sulphureus .
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-
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- HY-N10256
-
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Endogenous Metabolite
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Infection
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Varioxepine A is a 3H-oxepine-containing alkaloid with a new oxa-cage found in the marine algal-derived endophytic fungus Paecilomyces variotii. Varioxepine A inhibits plant pathogenic fungus Fusarium graminearum .
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-
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- HY-N12389
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Fungal
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Infection
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Quellenin is an anti-saprolegnia compound. Quellenin can be isolated from deep-sea fungus Aspergillus sp. YK-76
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-
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- HY-N8552
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-
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- HY-N10242
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Others
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Others
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Agonodepside B is a compound isolated from a nonsporulating filamentous fungus, F7524 .
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-
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- HY-N8532
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Others
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Others
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(1’S)-Dehydropestalotin (Compound 4) is a compound that can be isolated from the AcOEt extract of the fungus Xylaria feejeensis .
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-
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- HY-N10299
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-
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- HY-N8416
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(-)-Regiolone
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Others
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Others
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(-)-Isosclerone is a phytotoxic phenol. (-)-Isosclerone can be isolated from culture filtrate of Discula sp., the fungus responsible for dogwood anthracnose .
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-
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- HY-N10212
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Fungal
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Infection
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Dendryphiellin D is a compound isolated from fungus Septoria rudbeckiae, a plant pathogenic fungus isolated from the halophyte Karelinia caspia. Dendryphiellin D significantly inhibits the production of nitric oxide (NO) .
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-
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- HY-N10213
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NO Synthase
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Infection
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Septeremophilane E is a compound isolated from fungus Septoria rudbeckiae, a plant pathogenic fungus isolated from the halophyte Karelinia caspia. Septeremophilane E significantly inhibits the production of nitric oxide (NO) .
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-
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- HY-N8378
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Others
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Infection
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Clonostachydiol is an anthelmintic macrodiolide from the fungus Clonostachys cylindrospora (strain FH-A 6607) .
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-
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- HY-113622
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Palmarumycin C13; Diepoxin ζ; Antibiotic Sch53514
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Fungal
Antibiotic
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Infection
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Cladospirone bisepoxide is a metabolite that isolated from cultures of a fungus. Cladospirone bisepoxide displays selective antibiotic activity against several bacteria and fungi and inhibits germinations of Lepidium sativum at low concentrations .
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-
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- HY-N8846
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Fungal
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Infection
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dl-Aloesol is a natural product that can be isolated from fungus Aspergillus sp. Aspergillus sp metabolites has cytotoxic, antibacterial, free radical scavenging, anti-parasitic, antiviral and antiproliferative activities, etc .
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-
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- HY-N8621
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Others
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Others
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(11S)-(-)-Hydroxyjasmonic acid is a hydroxylated cyclopentane fatty acid of the jasmonic acid type that can be found in the culture filtrate of the fungus Botryodiplodia theobromae< .
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-
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- HY-126202
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Others
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Infection
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Lachnone A is a chromone derivative isolated from the filamentous fungus Lachnum sp. BCC 2424 .
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-
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- HY-N10217
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NO Synthase
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Inflammation/Immunology
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Paneolilludinic acid is a compound isolated from an endolichenic fungus Cryptomarasmius aucubae. Paneolilludinic acid significantly inhibits nitric oxide (NO) production .
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-
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- HY-N10301
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Toll-like Receptor (TLR)
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Infection
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Guignardone L is a metabolite isolated from the endophytic fungus Guignardia mangiferae with toll-like receptor 3 regulating activity .
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-
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- HY-135476
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(-)-Depudecin
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HDAC
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Neurological Disease
Cancer
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Depudecin ((-)-Depudecin) is a histone deacetylase (HDAC) inhibitor. Depudecin can be isolated from the fungus Alternaria brassicicola .
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-
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- HY-B1863
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Fungal
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Infection
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Iprobenfos is an organophosphorus fungicide and is widely used to control the rice blast fungus. Iprobenfos is also a choline biosynthesis inhibitor .
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- HY-N10214
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NO Synthase
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Inflammation/Immunology
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(-)-10,11-Dihydroxyfarnesol is a compound isolated from an endolichenic fungus Cryptomarasmius aucubae. (–)-10,11-Dihydroxyfarnesol significantly inhibits nitric oxide (NO) production .
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-
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- HY-N8864
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Others
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Others
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Isosativenediol is a sesquiterpene compound. Isosativenediol can be purified from Cochliobolus sativus, an endophytic fungus isolated from the desert plant Artemisia Desertorum .
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- HY-N7251
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Stachybotrysin
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Others
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Others
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Stachartin A is a phenylspirodrimane-type analogue. Stachartin A can be isolated from the tin mine tailings-associated fungus Stachybotrys chartarum .
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-
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- HY-N10285
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Tyrosinase
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Infection
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Phaeosphaone D is a thiodiketopiperazine alkaloid compound isolated from Phaeosphaeria fuckelii, an endophytic fungus. Phaeosphaone D displays mushroom tyrosinase inhibitory activity with an IC50 value of 33.2 μM .
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- HY-P2910
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GOase
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Endogenous Metabolite
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Others
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Galactose Oxidase, Dactylium dendroides (GOase) from fungus is often used in biochemical studies. Galactose oxidase is a type II copper metalloenzyme, and it containing a single polypeptide. Galactose oxidase catalyzes two-electron oxidation of primary alcohols to their corresponding aldehydes, coupling with the reduction of dioxygen to hydrogen peroxide .
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- HY-N10300
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Fungal
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Infection
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Guignardone K is a meroterpene compound isolated from solid cultures of the endophytic fungus Guignardia sp.. Guignardone K has antifungal activity .
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- HY-N9026
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Others
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Infection
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Stachartin B is a phenylspirodrimane-type analogue. Stachartin B can be isolated from the tin mine tailings-associated fungus Stachybotrys chartarum .
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- HY-N10239
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Others
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Metabolic Disease
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Aquastatin A is an inhibitor of mammalian adenosine triphosphatases. Aquastatin A is isolated from a fungus identified as Fusarium aquaeductuum. Aquastatin A inhibits Na+/K(+)-ATPase with an IC50 value of 7.1 μM, and H+/K(+)-ATPase with an apparent IC50 value of 6.2 μM .
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- HY-N7569
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Apoptosis
Caspase
PPAR
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Cancer
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Demethoxyfumitremorgin C is a secondary metabolite of the marine fungus, Aspergillus fumigatus. Demethoxyfumitremorgin C induces prostate cancer cell apoptosis. Demethoxyfumitremorgin C activates caspase-3, -8, and -9, leading to PARP/ cleavage .
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- HY-N10263
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Parasite
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Infection
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Palmarumycin C3 is a spirobisnaphthalene compound isolated from cultures of the endophytic fungus Berkleasmium sp. Dzf12 after treatment with 1-hexadecene. Palmarumycin C3 exhibits stronger antimicrobial and antioxidant activities .
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- HY-118065
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KBR 2738
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Fungal
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Infection
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Fenhexamid, a botryticide, is a sterol biosynthesis inhibitor. Fenhexamid shows fungicide efficient against the plant pathogenic fungus Botryotinia fuckeliana (Botrytis cinerea) .
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-
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- HY-N10203
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Endogenous Metabolite
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Cancer
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Rostratin A is a cytotoxic disulfide found in the marine-derived fungus Exserohilum rostratum. Rostratin A shows in vitro cytotoxicity against human colon carcinoma (HCT-116) with an IC50 of 8.5 μg/mL .
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- HY-123161
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Others
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Others
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JBIR-15 is a new aspochracin derivative. JBIR-15 is isolated from a sponge-derived fungus, Aspergillus sclerotiorum Huber Sp080903f04 .
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- HY-119663
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Fungal
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Infection
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Averantin is the minor metabolite of the fungus Cercospora arachidicola . Averantin is an aflatoxin B1 precursor that can be used in the biosynthetic pathway .
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- HY-N3394
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Others
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Infection
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Lecanoric acid is a histidine-decarboxylase inhibitor isolated from fungus. The inhibition by lecanoric acid is competitive with histidineand noncompetitive with pyridoxal phosphate. Lecanoric acid did not inhibit aromatic amino acid decarboxylase .
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- HY-N6294
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Bacterial
Fungal
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Infection
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Monocerin is an isocoumarin derivative. Monocerin is isolated from Microdochium bolleyi, an endophytic fungus from Fagonia cretica. Monocerin shows good antifungal, antibacterial, and antialgal activities against Microbotryum violaceum, Escherichia coli, Bacillus megaterium, and Chlorella fusca .
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- HY-N12337
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(+)-Asperazine
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Others
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Cancer
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Asperazine (Compound 5) is an alkaloid derived from the fungus Penicillium oxalicum. Asperazine shows only moderate activity against HepG2 and CaSki cell lines (IC50>50 μM) .
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- HY-N10947
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Others
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Others
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Lanosta-7,9(11),24-trien-3β,15α-dihydrcxy-26-oic acid (compound 2) is a nature product that could be isolated from the Chinese medicinal fungus Ganoderma lucidurn .
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-
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- HY-129325
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Antibiotic
Bacterial
Apoptosis
Bcl-2 Family
Caspase
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Infection
Cancer
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Cytochalasin H is a nature product that could be isolated from fungus Phomopsis sp. Cytochalasin H inhibits cell growth and induces apoptosis. Cytochalasin H has anti-angiogenic activity. Cytochalasin H is an antibiotic and has antibacterial activity .
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- HY-113623
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Others
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Others
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Pyrenophorol is a C9H12O3 compound isolated in low yield from culture filtrates of the phytopathogenic fungus Stemphylium radicinum, C.M.I. 105654 .
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-
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- HY-W164451
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Fungal
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Infection
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N-(2-hydroxy-2-phenylethyl)acetamide is isolated from the solid rice cultures of the endophytic fungus Diaporthe eucalyptorum KY-9. N-(2-hydroxy-2-phenylethyl)acetamide exhibits antifungal activities against Alternaria solani .
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-
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- HY-N10269
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Fungal
Endogenous Metabolite
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Infection
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Phomalactone, produced by the fungus Nigrospora sphaerica, specifically inhibits the mycelial growth of Phytophthora infestans, with an MIC value of 2.5 mg/L . Phomalactone is phytotoxic to Z. elegans and other plant species by inhibition of seedling growth and by causing electrolyte leakage from photosynthetic tissues of both Z. elegans leaves and cucumber cotyledons .
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- HY-N12165
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Others
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Others
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1,3,5,6-Tetrahydroxy-8-methylxanthone (compound 8) is a dimeric 1,4-benzoquinone derivative isolated from the marine-derived fungus Penicillium genus .
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-
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- HY-N12390
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Isocitrate Dehydrogenase (IDH)
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Cancer
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Alternaphenol B2 is a selective IDH1 inhibitor from the coral-derived fungus Parengyodontium album SCSIO SX7W11. Alternaphenol B2 shows inhibitory activity against isocitrate dehydrogenase mutant R132H (IDH1m), with IC50 values of 41.9 μM .
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- HY-N2646
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Fungal
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Infection
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5-Heptadec-cis-8-enylresorcinol is a 5-alkylresorcinol that can be isolated from etiolated rice seedlings. 5-Heptadec-cis-8-enylresorcinol is an antifungal agent against the rice blast fungus. 5-Heptadec-cis-8-enylresorcinol mediates DNA relaxation .
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- HY-121431
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Others
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Inflammation/Immunology
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FR-901235 is a new type of immunoactive substance produced by an imperfect fungus, Paecilomyces carneus F-4882. FR-901235 partially restored the impaired delayed-type hypersensitivity to sheep red blood cells in tumor-bearing mice .
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- HY-122467
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Bacterial
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Infection
Cancer
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Kumbicin C is a bis-indolyl benzenoid compound from an Australian soil fungus, Aspergillus kumbius. Kumbicin C inhibits the growth of mouse myeloma cells and the Gram-positive bacterium Bacillus subtilis .
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- HY-125568
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Others
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Others
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Pyridoxatin is a free radical scavenger of microbial origin. Pyridoxatin is isolated from a fungus culture identified as Acremonium sp. BX86. Pyridoxatin inhibits lipid peroxidation induced by free radicals in rat liver microsomes free from vitamin E .
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-
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- HY-N10208
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Endogenous Metabolite
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Cancer
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Aspericin C is a pyran derivative found in the marine-derived fungus Rhizopus sp. 2-PDA-61. Aspericin C shows cytotoxic activities against P388, A549, HL-60, and BEL-7420 cell lines (IC50=14.6, 7.1, 61.4, and 24.2 μM, respectively) .
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- HY-114979
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Antibiotic
Fungal
Apoptosis
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Infection
Cancer
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Pyoluteorin is an antibiotic that inhibits Oomycete fungi, including the plant pathogen Pythium ultimum, and suppresses plant diseases caused by this fungus . Pyoluteorin induces human triple-negative breast cancer MDA-MB-231 cells apoptosis in vitro. Pyoluteorin can be used for the research of human triple-negative breast cancer .
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- HY-119328
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- HY-129642
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Others
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Others
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Hirsutide is a cyclic tetrapeptide that can be found in spider-derived entomopathogenic fungus .
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- HY-N12197
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Others
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Others
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Terretonin A is a meroterpenoid that can be isolated from the endophytic fungus Aspergillus terreus .
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- HY-N12206
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Semicochliodinol A
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Others
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Others
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Semicochliodinol can be isolated from rice cultures of the fungus genus Chaetomium .
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- HY-123100
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Others
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Others
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Ganoderic acid N is a natural terpenoid isolated from the Fungus Ganoderma lucidum .
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- HY-129515
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Fungal
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Others
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Trichodecenin II is a fungal metabolite that can be found in conidia of the fungus, Trichoderma viride .
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- HY-125298
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Parasite
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Infection
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Cycloaspeptide A, isolated from the endophytic fungus Penicillium janczewskii, has antiparasitic activity .
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- HY-N12184
-
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Others
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Others
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Peniciside is a triterpenoid glycoside derived from the fungus Penicillium sp.169 .
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-
- HY-N2990
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3β,16α-Dihydroxylanosta-7,9(11),24-trien-21-oic acid
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Others
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Inflammation/Immunology
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16α-Hydroxydehydrotrametenolic acid is a triterpene Acid in fermented mycelia of edible fungus Poria cocos .
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- HY-125666
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Others
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Infection
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Agistatin B, isolated from fungus, is a mycotoxin. Agistatin B inhibits cholesterol synthesis .
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- HY-N10241
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Others
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Others
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Hortein is a natural product from the fungus Hortaea werneckii associated with the sponge Aplysina aerophoba .
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- HY-113972
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Others
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Inflammation/Immunology
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Methyl mycophenolate is a methyl ester of mycophenolic acid and is also found in marine-derived fungus Phaeosphaeria spartinae .
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- HY-N3290
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Methyl p-methoxyphenylpropionate
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Others
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Others
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Methyl p-methoxyhydrocinnamate is extracted from in liquid culture by the blue stain fungus Ophiostoma crassioaginata .
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- HY-N12193
-
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Others
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Others
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Cytochalasin N is a cytorelaxin derived from endophytic fungus Phomopsis sp.CIB-109 .
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- HY-125706
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-
- HY-N10427
-
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Others
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Others
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5,6-Epoxyergosterol is a natural product that can be isolated from endophytic fungus Phyllosticta capitalensis .
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- HY-N12194
-
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Others
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Infection
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Cytochalasin O (compound 13) is a secondary metabolite of the phytopathogenic fungus P. sp. CIB-109 .
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- HY-N7023
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7-O-Prenylumbelliferone
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Fungal
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Infection
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7-Prenyloxycoumarin (7-O-Prenylumbelliferone) is a secondary metabolite from the endophytic fungus of Annulohypoxylon ilanense .
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- HY-N8571
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Others
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Others
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6-Methoxyflavonol (Compound 15) is a natural flavone isolated from the marine-derived fungus Aspergillus candidus .
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- HY-N6689
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Antibiotic
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Infection
Cancer
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Destruxin A (DA) is a cyclo-peptidic mycotoxin from the entomopathogenic fungus Metarhizium anisopliae, with insecticidal, anti-viral and antiproliferative activities .
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- HY-138098
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Others
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Cancer
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Sartorypyrone B is a 2β-acetoxyl analogue of chevalone C. Sartorypyrone B is yielded from the ethyl acetate extract of the culture of the marine sponge-associated fungus Neosartorya tsunodae (KUFC 9213). Sartorypyrone B exhibits strong growth inhibitory activity, having GI50s of 17.8, 20.5, and 25.0 μM, respectively, for MCF-7, NCI-H460, and A375-C5. Sartorypyrone B has the potential for the research of breast adenocarcinoma, non-small cell lung cancer, and melanoma diseases .
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- HY-N6793
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Microtubule/Tubulin
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Cancer
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Phomopsin A is a cyclic hexapeptide mycotoxin isolated from the fungus Phomopsis leptostomiformis. Phomopsin A is a noncompetitive inhibitor of the binding of radiolabeled vincristine to tubulin .
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- HY-N10200
-
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Others
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Others
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2,7-Dimethoxy-6-(1-acetoxyethyl)juglone is a naphthoquinone derivative found in the fungus Kirschsteiniothelia species .
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- HY-N10262
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Endogenous Metabolite
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Others
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Piliformic acid is a fungal metabolite found in the endophytic fungus Xylariasp sp.(No. 2508) from mangrove trees from the coast of the South China Sea .
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-
- HY-N2997
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|
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Others
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Cancer
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Ganoderic acid LM2 is a natural terpenoid isolated from the Fungus Ganoderma lucidum. Ganoderic acid LM2 possesses potential anti-tumor activity .
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- HY-N9312
-
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Others
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Inflammation/Immunology
|
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Ganoderic acid J is a natural terpenoid isolated from the Fungus Ganoderma lucidum. Ganoderic acid J possesses anti-inflammatory anti-inflammatory activity .
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- HY-N12118
-
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Fungal
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Infection
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Piperanine is an antifungal agent. Piperanine shows growth inhibition against the fungus Cladosporium claspoirioides. Piperanine can be isolated from the fruits of Piper retrofractum .
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- HY-N9350
-
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Others
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Cancer
|
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Ganoderic acid ε is a natural terpenoid isolated from the Fungus Ganoderma lucidum. Ganoderic acid ε exhibits an ED50 of 12.2 μg/mL in Meth-A tumor cells
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- HY-N9599
-
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Others
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Others
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Roridin A is an inhibitor of pollen development in Arabidopsis thaliana. Roridin A is isolated from the fungus Cylindrocarpon sp. Roridin A inhibits the pollen development at concentrations of 2 μM .
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- HY-N10289
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Fungal
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Infection
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Cytosporone C is an antifungal metabolite from the Melia azedarach-Associated Fungus Diaporthe eucalyptorum. Cytosporone C exhibits antifungal activities against Alternaria solani .
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-
- HY-N8443
-
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Bacterial
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Infection
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Isoaltenuene is an anti-bacterial agent with moderate activity against Staphylococcus aureus. Isoaltenuene can be isolated from fungus Alternaria alternate cib-137 .
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- HY-N4116
-
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Fungal
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Infection
Cancer
|
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Xanthyletin is a coumarin isolated from Stauranthus perforatus, with anti-tumor and anti-bacterial activities. Xanthyletin also inhibits symbiotic fungus cultivated by leaf-cutting ants .
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-
- HY-119821
-
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Glucosidase
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Infection
|
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Terphenyllin is a naturally abundant p-terphenyl metabolite isolated from the coral derived fungus Aspergillus candidus, has significant α-glucosidase inhibitory activity .
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-
- HY-W006429
-
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Endogenous Metabolite
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Metabolic Disease
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L-Uridine, isolated from the Polyporaceae fungus Poria cocos (Schw.), is an enantiomer of the normal RNA constituent D-uridine. L-uridine acts as a phosphate acceptor for nucleoside phosphotransferases .
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- HY-N7151
-
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Antibiotic
Bacterial
Fungal
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Infection
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Aurachin D is an antibiotic. Aurachin D inhibits Gram-positive bacteria and a few funguses. Aurachin D blocks NADH oxidation in beef heart submitochondrial particles .
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- HY-N8520
-
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Bacterial
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Infection
Cancer
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Variculanol is an antimicrobial, anticancer and anti-HCV NS3/4A Protease agent which can be extracted from marine fungus Aspergillus versicolor .
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-
- HY-N7435
-
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(±)-Massoia lactone
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Biochemical Assay Reagents
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Others
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Massoia lactone ((±)-Massoia lactone) is a coconut and creamy fragrant compound mianly isolated from Cryptocarya massoy. Massoia lactone is also a fragrant biosurfactant produced by a fungus Aureobasidium pullulans .
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- HY-126597
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Bacterial
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Infection
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Chaetoglobosin C (Compound 4) is a anthraquinone-chromone compound derived from the fungus Chaetomium globosum KMITL-N0802. Chaetoglobosin C has anti-tuberculosis activity .
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- HY-N12195
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Fungal
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Infection
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Cytochalasin R (compound 17) is a cytochalasin analogue that can be isolated from the endophytic fungus Phomopsis sp. xz-18. Cytochalasin R shows potential antifungal activity .
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-
- HY-W133982
-
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Biochemical Assay Reagents
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Infection
|
|
Corn steep liquor, a food industrial by-product, is a nutritional additive in the liquid culture medium of fungus. Corn steep liquor can increase the production of fairy chemicals and mycelia .
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- HY-N3502
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HIV Protease
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Infection
|
|
20(21)-Dehydrolucidenic acid A is a triterpenoid isolated from the fruiting body of the fungus Ganoderma sinense. 20(21)-Dehydrolucidenic acid A has weak anti-HIV-1 protease activity .
|
-
- HY-D0008
-
|
|
Bacterial
Fungal
Parasite
|
Infection
|
|
Brilliant green is a cationic dye used to color silk and wool. Brilliant green inhibits propagation of mold, intestinal parasites and fungus. Brilliant green is effective against Gram-positive bacteria .
|
-
- HY-N10332
-
|
|
Proteasome
|
Cancer
|
|
Leptosphaerodione, isolated from Remotididymella sp. Fungus, is a potent ubiquitin-proteasome system (UPS) inhibitor. Leptosphaerodione exhibits cytotoxicity in HeLa cells with IC50 value of 3.2 μM. Anti-tumor agent .
|
-
- HY-N12179
-
|
|
Bacterial
|
Others
|
|
Brevianamide M (compound 4) is a metabolite of Aspergillus versicolor. This is an endophytic fungus isolated from the marine brown alga Sargassum. Brevianamide M has antimicrobial activity against Escherichia coli and Staphylococcus aureus .
|
-
- HY-162256
-
|
|
Fungal
|
Infection
|
|
Antibacterial agent 184 (compound 4j) is a fungal inhibitor that is toxic to the plant pathogenic fungus Sclerotinia sclerotiorum. Antibacterial agent 184 can effectively inhibit Sclerotinia sclerotiorum (IR>97%) .
|
-
- HY-N8498
-
|
|
Apoptosis
|
Cancer
|
|
GKK1032B is an alkaloid compound that can be found in endophytic fungus Penicillium sp. GKK1032B can induce the apoptosis of human osteosarcoma MG63 cells through caspase pathway activation .
|
-
- HY-116474
-
|
|
Fungal
|
Infection
|
|
Viridicatol, a quinolinone alkaloid, is isolated from the fermentation of an endophytic fungus Penicillium sp. R22 in Nerium indicum. Viridicatol has strong antifungal activity against Staphylococcus aureus with MIC value of 15.6 μg/mL .
|
-
- HY-N8511
-
|
|
Fungal
|
Infection
|
|
Acremine I is a fungi inhibitor and also a metabolite of the endophytic fungus Acremonium byssoides. Acremine I can effectively inhibit Plasmopara viticola. Acremine I can be used for research on plant diseases, such as grape downy mildew .
|
-
- HY-119726
-
|
APX001; E1211
|
Fungal
|
Infection
Inflammation/Immunology
|
|
Fosmanogepix (APX001) is a broad-spectrum agent against invasive fungal infections. Fosmanogepix (APX001) targets the conserved Gwt1 enzyme required for the localization of glycosylphosphatidylinositol-anchored mannoproteins in fungi. This inhibition prevents the appropriate localization of cell wall mannoproteins, which compromises cell wall integrity, biofilm formation, germ tube formation, and fungal growth. Fosmanogepix (APX001) can be used for invasive fungal infections research .
|
-
- HY-75564
-
|
|
Endogenous Metabolite
|
Cancer
|
|
Cyclo(Ala-Gly), a metabolite of a mangrove endophytic fungus, Penicillium thomi, exhibits cytotoxicity against A549, HepG2 and HT29 cells. The IC50 values range from 9.5 to 18.1 μM .
|
-
- HY-N6181
-
|
|
Others
|
Endocrinology
|
|
Terrelumamide A is a lumazine-containing peptide. Terrelumamide A is isolated from the culture broth of the marine-derived fungus Aspergillus terreus. Terrelumamide A exhibits pharmacological activity by improving insulin sensitivity. Terrelumamide A has the potential in the application of DNA sequence recognition .
|
-
- HY-N8406
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Monomethylsulochrin is a potent antibacterial metabolite from endophytic fungus Aspergillus fumigatus, isolated from Albizia lucidior leaves (fabaceae). Monomethylsulochrin exhibits anti-Staphylococcus aureus activity with minimum inhibitory concentration (MIC) of 31.25 μg/mL .
|
-
- HY-B0751
-
|
Amebacilin; NSC9168
|
Parasite
HIV
Antibiotic
|
Infection
|
|
Fumagillin(NSC9168) is an antimicrobial compound first isolated in 1949 from the fungus Aspergillus fumigatu. Fumagillin can inhibits HIV‐1 infection through the inhibition of HIV-1 viral protein R (Vpr) activity.
|
-
- HY-N10229
-
|
|
Fungal
Antibiotic
|
Infection
|
|
Harzianum A is a trichothecene that isolated from the soil-borne fungus Trichoderma harzianum. Harzianum A shows no cytotoxicity against baby hamster kidney cells, no activity against Gram-negative and Gram-positive bacteria, but modest antifungal activity at 100 μg/mL .
|
-
- HY-135549
-
|
|
Fungal
Antibiotic
|
Infection
|
|
Fluxapyroxad is a synthetic broad-spectrum fungicide for the control of fungal diseases. It works by inhibiting succinate dehydrogenase in complex II of the mitochondrial respiratory chain, resulting in inhibition of spore germination, germ tubes and mycelia growth within the fungus target species .
|
-
- HY-119458
-
|
|
Topoisomerase
TMV
Fungal
|
Infection
|
|
Luotonin A is an antiviral and antiphytopathogenic fungus agent. Luotonin A has good antiviral activity against tobacco mosaic virus (TMV). Luotonin A also has certain inhibitory activity on topoisomerase I and topoisomerase II. Luotonin A shows antitumor activity .
|
-
- HY-B1350A
-
|
Sodium fusidate; SQ-16360
|
Bacterial
Antibiotic
|
Infection
Cancer
|
|
Fusidic acid sodium salt (Sodium fusidate), a bacteriostatic antibiotic produced from the Fusidium coccineum fungus, belongs to the class of steroids. Fusidic acid sodium salt has no corticosteroid effects. Fusidic acid sodium salt inhibits the growth of bacteria by preventing the release of translation elongation factor G (EF-G) from the ribosome .
|
-
- HY-B1350
-
|
Fusidate; SQ-16603
|
Bacterial
Antibiotic
|
Infection
Cancer
|
|
Fusidic acid (Fusidate) a bacteriostatic antibiotic produced from the Fusidium coccineum fungus, belongs to the class of steroids. Fusidic acid has no corticosteroid effects. Fusidic acid inhibits the growth of bacteria by preventing the release of translation elongation factor G (EF-G) from the ribosome .
|
-
- HY-N8105
-
|
|
Fungal
|
Infection
Cancer
|
|
Protoneogracillin, a furostanol glycoside, shows anti-fungal activity against the plant pathogenic fungus P.oryzae (MMDC=94.0 μM) and cytotoxic activity on K562 cancer cells (IC50=6.6 μM) .
|
-
- HY-N8908
-
|
|
Others
|
Infection
|
|
2α,9α,11-Trihydroxy-6-oxodrim-7-ene is a natural product that can be isolated from the culture medium of the marine-derived fungus Aspergillus insuetus .
|
-
- HY-A0210
-
-
- HY-N10184
-
|
FKI-0550
|
Others
|
Infection
|
|
Paecilaminol (FKI-0550) is potent NADH-fumarate reductase inhibitor. Paecilaminol exhibits an IC50 value of 5.1 μM against Ascaris suum NADH-fumarate reductase .
|
-
- HY-N10280
-
|
|
Bacterial
Endogenous Metabolite
|
Infection
|
|
Asperglaucin A represents an unusual phthalide-like derivative. Asperglaucin A exhibits potent antibacterial activities against two plant pathogens Pseudomonas syringae pv actinidae (Psa) and Bacillus cereus, with an MIC value of 6.25 μM .
|
-
- HY-124555
-
|
Benzimine
|
Fungal
|
Infection
|
|
Hexamide (Benzamine) is a fungal inhibitor. Hexamide is effective against Trichophyton .
|
-
- HY-N12266
-
|
|
Others
|
Others
|
|
12-Hydroxyalbrassitriol is a drimane sesquiterpenoid that can be isolated from Penicillium sp .
|
-
- HY-12361
-
|
|
Parasite
|
Infection
|
|
PF 1022A is a cyclooctadepsipeptide with broadspectrum anthelmintic properties produced by fermentation of the fungus Mycelia sterilia. PF 1022A is a channel-forming ionophore. PF 1022A showes strong anthelmintic activities against Ascaridia galli in chickens. PF 1022A also can be used for angiostrongyliasis research .
|
-
- HY-P1508
-
|
Bactenecin, bovine
|
Bacterial
Fungal
Antibiotic
|
Infection
|
|
Bactenecin (Bactenecin, bovine) is a potent 12-aa looped antimicrobial peptide isolated from bovine neutrophils. Bactenecin inhibits the growth of bacteria and yeast, and kills the fungus Trichophyton rubrum. Bactenecin increass membrane permeability, inhibits the growth and biofilm formation of B. pseudomallei .
|
-
- HY-W663230
-
|
|
Parasite
|
Infection
|
|
Eugenitin is a polyketide isolated from the fungus Mycoleptodiscus indicus that is related to the South American medicinal plant. Eugenitin inhibits Leishmania major with LD50=39.9 μM. Eugenitin has low cytotoxicity (IC50 >131 μM) against several human cancer cell lines .
|
-
- HY-N10281
-
|
|
Bacterial
|
Infection
|
|
Asperglaucin B is an alkylated salicylaldehyde derivative from the fungus Aspergillus chevalieri SQ-8, with antibacterial activities. Asperglaucin B displays potent antibacterial activities against two plant pathogens Pseudomonas syringae pv actinidae (Psa) and Bacillus cereus, with an MIC value of 6.25 μM .
|
-
- HY-N10502
-
|
|
MDM-2/p53
HSP
|
Cancer
|
|
Colletofragarone A2 can be be isolated from the fungus Colletotrichum sp. (13S020). Colletofragarone A2 inhibits mutant p53 and HSP90 with anti-cancer activity. Colletofragarone A2 promotes degradation and aggregation of mutant p53 and suppressing tumor growth in vivo .
|
-
- HY-N8537
-
|
|
Fungal
|
Infection
|
|
Enfumafungin, a triterpene glycoside, is isolated from extracts derived from fungus Hormonema carpetanum. Enfumafungin is an antifungal compound that is acting on the fungal cell wall, as the (1,3)-beta-D-glucan synthase inhibitor. Enfumafungin is specific for yeasts and fungi (excluding Cryptococcus) and does not inhibit the growth of Bacillus subtilis .
|
-
- HY-118736
-
|
|
Others
|
Cardiovascular Disease
|
|
Ganodermic acid S is an oxygenated triterpenoid, that can be isolated from the Chinese medicinal fungus Ganoderma lucidum (Fr.) Karst (Polyporaceae). Ganodermic acid S exerts a concentration dependent inhibition on the response of human gel-filtered platelets (GFP) to U-46619 (HY-108566), a thromboxane (TX) A2 mimetic .
|
-
- HY-P1508A
-
|
Bactenecin, bovine TFA
|
Bacterial
Fungal
|
Infection
|
|
Bactenecin TFA (Bactenecin, bovine TFA) is a potent 12-aa looped antimicrobial peptide isolated from bovine neutrophils. Bactenecin TFA inhibits the growth of bacteria and yeast, and kills the fungus Trichophyton rubrum. Bactenecin TFA increass membrane permeability, inhibits the growth and biofilm formation of B. pseudomallei .
|
-
- HY-133537
-
|
|
Antibiotic
Fungal
ADC Cytotoxin
|
Infection
Cancer
|
|
Hygrolidin is a 16-membered macrolide antibiotic produced by Streptomyces hygroscopicus D-1166. Hygrolidin has anti-fungus activity against Valsa ceratosperma. Hygrolidin induces p21 expression and abrogates cell cycle progression at G1 and S phases. Hygrolidin has antitumor activity .
|
-
- HY-B1350S
-
|
Fusidate-d6; SQ-16603-d6
|
Bacterial
Antibiotic
|
Infection
|
|
Fusidic acid-d6 is the deuterium labeled Fusidic acid. Fusidic acid (Fusidate) a bacteriostatic antibiotic produced from the Fusidium coccineum fungus, belongs to the class of steroids. Fusidic acid has no corticosteroid effects. Fusidic acid inhibits the growth of bacteria by preventing the release of translation elongation factor G (EF-G) from the ribosome[1][2].
|
-
- HY-156241
-
|
|
NO Synthase
Fungal
|
Infection
Inflammation/Immunology
|
|
Meliadubin B is a natural triterpenoid with significant inflammatory inhibition effect toward superoxide anion generation in human neutrophils (EC50 of 5.54 μM). Meliadubin B inhibits inducible nitric oxide synthase. Meliadubin B shows remarkable inhibition against the rice pathogenic fungus Magnaporthe oryzae with IC50 of 182.50 μM.
|
-
- HY-N10288
-
-
- HY-N7731
-
|
|
Others
|
Others
|
|
(±)-Lavandulol is an irregular monoterpene alcohol. (±)-Lavandulol can be transformed by a fungal strain Rhizopus oryzae into corresponding oxygenated metabolite .
|
-
- HY-N9003
-
|
|
Others
|
Cancer
|
|
Dihydroprehelminthosporol (Compound 1) from the
fungusVeronaea sp.of the separated. Dihydroprehelminthosporol on
human cancer cell line A549 and SK-0A-3 has cytotoxicity .
|
-
- HY-142088
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Beauverolide Ka, a cyclotetradepsipeptide, is a metabolite of Beauveria bassiana fungus. Beauverolide Ka stimulates glucose uptake in cultured rat L6 myoblasts at 50 μM. Beauverolide Ka exhibits protecting effects on HEI-OC1 cells at 10 μM and shows dose-dependent activity in both L6 myoblasts and myotubes .
|
-
- HY-N12177
-
|
|
Phosphatase
|
Metabolic Disease
|
|
Cryptosporioptide A (Compound 3) is a pigment protein tyrosine phosphatase inhibitor derived from the insect-parasitic fungus Cordyceps gracilioides. Cryptosporioptide A inhibits PTP1B, SHP2, CDC25B, LAR and SHP1 enzymes with IC50 of 7.3, 5.7, 7.6, >50, 4.9 μg/mL, respectively .
|
-
- HY-B1350R
-
|
Fusidate (Standard); SQ-16603 (Standard)
|
Antibiotic
Bacterial
|
Cancer
|
|
Fusidic acid (Standard) is the analytical standard of Fusidic acid. This product is intended for research and analytical applications. Fusidic acid (Fusidate) a bacteriostatic antibiotic produced from the Fusidium coccineum fungus, belongs to the class of steroids. Fusidic acid has no corticosteroid effects. Fusidic acid inhibits the growth of bacteria by preventing the release of translation elongation factor G (EF-G) from the ribosome .
|
-
- HY-116686
-
|
|
Cytochrome P450
Fungal
|
Infection
|
|
Inz-1 is a potent and selective mitochondrial cytochrome bc1 inhibitor for yeast (IC50=8.092 μM) over humans (IC50=45.320 μM). Inz-1 reverses Fluconazole (HY-B0101) or other triazole antifungals’ resistance in the pathogenic fungus Candida albicans .
|
-
- HY-P2902
-
|
|
Endogenous Metabolite
|
Cancer
|
|
Glucose oxidase is used in the food and beverage industry as a preservative and stabilizer and is commonly derived from the fungus Aspergillus niger. Glucose oxidase can react with intracellular glucose and oxygen (O2) to produce hydrogen peroxide (H2O2) and gluconic acid, which can cut off the nutrition source of cancer cells and consequently inhibit their proliferation .
|
-
- HY-N12386
-
|
|
Sirtuin
|
Cancer
|
|
SIRT1 activator 1(compound 3) is a derivative of marine compound xyloallenoide A isolated from the mangrove fungus Xylaria sp.SIRT1 activator 1 shows angiogenic activities in zebrafish. SIRT1 activator 1 protects hEPC against AngII-induced senescence by increasing SIRT1 expression levels and balancing the AMPK/Akt signaling pathway .
|
-
- HY-N12726
-
|
|
p38 MAPK
MMP
|
Infection
Inflammation/Immunology
Cancer
|
Halociline, a derivative of alkaloids, that can be isolated from the marine fungus Penicillium griseofulvum.
Halociline targets MAPK1, MMP-9, and PIK3CA in gastric cancer cells, potentially mediated by diverse pathways including cancer, lipid metabolism, atherosclerosis, and EGFR tyrosine kinase inhibitor resistance. Halociline possesses antimicrobial, antioxidant and biofilm inhibitory activities .
|
-
- HY-N7307
-
|
|
Bacterial
|
Infection
|
|
Pachybasin is a major metabolite from culture broth of endophytic coelomyceteous AFKR-18 fungus. Pachybasin showes antimicrobial activities against E. coli, B. subtilis, M. luteus, S. cerevisiae, C. albicans, A. niger, and A. flavus, with MIC values of 64.0 μg/mL, and against S. aureus and F. oxysporum with MIC values of 32.0 and 16.0 μg/mL respectively .
|
-
- HY-N3570
-
|
|
Fungal
|
Infection
|
|
Cerebroside B, a sphingolipid compound, is a non-racespecific elicitor, which elicits defense responses in rice .
|
-
- HY-107426
-
|
Muconomycin A
|
Apoptosis
Reactive Oxygen Species
|
Cancer
|
|
Verrucarin A (Muconomycin A), a Type D macrocyclic mycotoxin derived from the pathogen fungus Myrothecium verrucaria, is an inhibitor of protein synthesis. Verrucarin A inhibits growth of leukemia cell lines and activates caspases and apoptosis and inflammatory signaling in macrophages. Verrucarin A effectively increased the phosphorylation of p38 MAPK and diminished the phosphorylation of ERK/Akt. Verrucarin A caused cell cycle deregulation through the induction of p21 and p53 .
|
-
- HY-N6690
-
|
|
Bcl-2 Family
Caspase
Apoptosis
|
Infection
Cancer
|
|
Destruxin B, isolated from entomopathogenic fungus Metarhizium anisopliae, is one of the cyclodepsipeptides with insecticidal and anticancer activities. Destruxin B induces apoptosis via a Bcl-2 Family-dependent mitochondrial pathway in human nonsmall cell lung cancer cells . Destruxin B significantly activates caspase-3 and reduces tumor cell proliferation through caspase-mediated apoptosis, not only in vitro but also in vivo .
|
-
- HY-N10113
-
|
Muconomycin B
|
Apoptosis
Arenavirus
Fungal
Antibiotic
Reactive Oxygen Species
|
Infection
Cancer
|
|
Verrucarin J (Muconomycin B) is a metabolite of the Myrothecium fungus family. Verrucarin J generates reactive oxygen species (ROS) and induces apoptosis of cancer cell lines, such as A549, HCT 116 and SW-620 cells. Verrucarin J shows activities against Candida albicans and Mucor miehei. Verrucarin J inhibits arenavirus Junin (JUNV) yield with an IC50 of 1.2 ng/mL .
|
-
- HY-N12198
-
|
|
Others
|
Cancer
|
|
Mollicellin H is a secondary metabolite of the fungus C. brasiliense and has a wide range of biological activities, including immunomodulation, cytotoxicity and anti-tumor effects. The growth inhibitory effects (GI50s) of Mollicellin H on human breast cancer (Bre04), human lung (Lu04) and human neuroma (N04) cell lines are 5.1 μg/mL, 6.5 μg/mL and 2.5 μg/mL respectively .
|
-
- HY-B1290S
-
|
Phenylethyl alcohol-d4; Phenethyl alcohol-d4; Benzyl carbinol-d4
|
Bacterial
Virus Protease
Antibiotic
|
Infection
|
|
2-Phenylethanol-d4 is the deuterium labeled 2-Phenylethanol[1]. 2-Phenylethanol (Phenethyl alcohol), extracted from rose, carnation, hyacinth, Aleppo pine, orange blossom and other organisms, is a colourless liquid. It has a pleasant floral odor and also an autoantibiotic produced by the fungus Candida albicans[2]. It is used as an additive in cigarettes and also used as a preservative in soaps due to its stability in basic conditions.
|
-
- HY-B1290S1
-
|
Phenylethyl alcohol-d9; Phenethyl alcohol-d9; Benzyl carbinol-d9
|
Bacterial
Virus Protease
Antibiotic
|
Infection
|
|
2-Phenylethanol-d9 is the deuterium labeled 2-Phenylethanol[1]. 2-Phenylethanol (Phenethyl alcohol), extracted from rose, carnation, hyacinth, Aleppo pine, orange blossom and other organisms, is a colourless liquid. It has a pleasant floral odor and also an autoantibiotic produced by the fungus Candida albicans[2]. It is used as an additive in cigarettes and also used as a preservative in soaps due to its stability in basic conditions.
|
-
- HY-B1290S2
-
|
Phenylethyl alcohol-d5; Phenethyl alcohol-d5; Benzyl carbinol-d5
|
Bacterial
Virus Protease
Antibiotic
|
Infection
|
|
2-Phenylethanol-d5 is the deuterium labeled 2-Phenylethanol[1]. 2-Phenylethanol (Phenethyl alcohol), extracted from rose, carnation, hyacinth, Aleppo pine, orange blossom and other organisms, is a colourless liquid. It has a pleasant floral odor and also an autoantibiotic produced by the fungus Candida albicans[2]. It is used as an additive in cigarettes and also used as a preservative in soaps due to its stability in basic conditions.
|
-
- HY-126810A
-
|
|
Fungal
|
Infection
|
|
NP213 TFA is a rapidly acting, novel, first-in-class synthetic antimicrobial peptide (AMP), has anti-fungal activities. NP213 TFA targets the fungal cytoplasmic membrane and plays it role via membrane perturbation and disruption. NP213 TFA is effective and well-tolerated in resolving nail fungal infections .
|
-
- HY-N10286
-
|
|
Tyrosinase
|
Others
|
|
Chetoseminudin B possesses mushroom tyrosinase inhibitory activity with IC50 of 31.7 μM .
|
-
- HY-N1964
-
|
Gibberellin A3
|
|
|
|
Gibberellic Acid is named after the fungus Gibberella fujikuroi. Gibberellic Acid regulates processes in plant development and growth, including seed development and germination, stem and root growth, cell division, and flowering time. Gibberellic Acid also improves plant response to growth stress caused by various environmental stresses, such as cold stress, drought stress, heavy metal stress, etc. Gibberellic Acid also causes increased lipid peroxidation and fluctuations in the antioxidant defense system in rats .
|
-
- HY-162329
-
|
|
Bacterial
Fungal
Antibiotic
|
Infection
Inflammation/Immunology
|
|
Antibacterial agent 195 (compound A20), a Matrine (HY-N0164) derivative, is a potent antibiotic. Antibacterial agent 195 shows antibacterial activity against Gram-positive bacterium (MICS.aureus=0.021 mg/mL; MICP.acnes=0.030 mg/mL), Gram-negative bacterium (MICE.coli=0.092 mg/mL; MICC.albicans=0.379 mg/mL) and Fungus (MIC=2.806 mg/mL) .
|
-
- HY-D0027
-
|
Coumarin 120; AMC
|
Fluorescent Dye
Antibiotic
Fungal
|
Infection
|
|
7-Amino-4-methylcoumarin belongs to a group of coumarins. 7-Amino-4-methylcoumarin can be isolated from an endophytic fungus Xylaria sp., has broad antimicrobial activity. 7-Amino-4-methylcoumarin is additionally commonly used as an important laser dye emitting in the blue region, as well as a fluorescent probe enabling analyses of glycoproteins’ monosaccharides and N-linked oligosaccharides. The excitation wavelength and emission wavelength are 351 nm and 430 nm, respectively .
|
-
- HY-N12561
-
|
|
ERK
p38 MAPK
JNK
|
Others
|
|
Pestanoid A is a rearranged pimarane diterpenoid osteoclastogenesis inhibitor with an IC50 of 4.2 μM. Pestanoid A can be isolated from the marine mesophotic zone chalinidae sponge-associated fungus, Pestalotiopsis sp. NBUF145. Pestanoid A inhibits the receptor activator of NF-kB ligand-induced MAPK and NF-κB signaling by suppressing the phosphorylation of ERK1/2-JNK1/2-p38 MAPKs and NF-κB nuclear translocation. Pestanoid A can be used for the study of osteoporosis .
|
-
- HY-126810
-
|
|
Fungal
|
Infection
|
|
NP213 is a rapidly acting, novel, first-in-class synthetic antimicrobial peptide (AMP), has anti-fungal activities. NP213 targets the fungal cytoplasmic membrane and plays it role via membrane perturbation and disruption. NP213 is effective and well-tolerated in resolving nail fungal infections .
|
-
- HY-N6682
-
Cytochalasin D
Maximum Cited Publications
40 Publications Verification
Zygosporin A; NSC 209835
|
Arp2/3 Complex
Antibiotic
YAP
|
Infection
|
|
Cytochalasin D (Zygosporin A) is a potent actin polymerization inhibitor, could be derived from fungus. Cytochalasin D has cell-permeable activity. Cytochalasin D inhibits the G-actin–cofilin interaction by binding to G-actin. Cytochalasin D also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells. Cytochalasin D can reduce exosome release, in turn reducing the amount of survivin present in the tumour environment. Cytochalasin D induces phosphorylation and cytoplasmic retention of Yap .
|
-
- HY-N6711
-
|
|
HIV Integrase
|
Infection
|
|
Equisetin is an N-methylserine-derived acyl tetramic acid isolated from a terrestrial fungus Fusarium equiseti NRRL 5537 . Equisetin is a tetramate-containing natural product with antibiotic and cytotoxic activity . Equisetin inhibits the growth of Gram-positive bacteria and HIV-1 integrase activity but shows no activity against Gram-negative bacteria . Equisetin is a Quorum-sensing inhibitor (QSI) that attenuates QS-regulated virulence phenotypes in P. aeruginosa without affecting the growth of bacterias, serves as a leading compound for the treatment of P. aeruginosa infections .
|
-
- HY-N7432
-
|
|
Antibiotic
Bacterial
Fungal
|
Infection
|
|
DIMBOA, an antibiotic, has antibacterial properties and inhibits bacteria such as Staphylococcus aureus and the mycotoxin-producing fungus Fusarium graminearum (which causes scab). DIMBOA exhibits strong free radical scavenging activity and weak iron(III) ion reducing activity, and has antioxidant activity. DIMBOA inhibits the biosynthesis and accumulation of toxic trichothecenes by affecting the expression of Tri6 and Tri5. DIMBOA reduces plant susceptibility to scab. DIMBOA also exhibits cytotoxicity to plant cells, causing plasmolysis, cell collapse, and cell rupture .
|
-
- HY-121197
-
|
Ophiocordin; Azepinostatin
|
PKA
PKC
|
Others
|
|
Balanol (Ophiocordin; Azepinostatin) is a potent and ATP competitive PKC/PKA inhibitor against human PKC isozymes α, β-I, β-II, γ, δ, ε, η (IC50s=4-9 nM) and ζ (IC50=150 nM). Balanol also blocks the phosphorylation of cyclic AMP response element-binding protein (CREB) and myristoylated alanine-rich C kinase substrate (MARCKS). Balanol can be isolated from the fungus Verticillium balanoides .
|
-
- HY-N1964R
-
|
Gibberellin A3 (Standard)
|
Others
|
Others
|
|
Gibberellic acid (Standard) is the analytical standard of Gibberellic acid. This product is intended for research and analytical applications. Gibberellic Acid is named after the fungus Gibberella fujikuroi. Gibberellic Acid regulates processes in plant development and growth, including seed development and germination, stem and root growth, cell division, and flowering time. Gibberellic Acid also improves plant response to growth stress caused by various environmental stresses, such as cold stress, drought stress, heavy metal stress, etc. Gibberellic Acid also causes increased lipid peroxidation and fluctuations in the antioxidant defense system in rats .
|
-
- HY-N11528
-
|
7-Noreugenitin
|
Others
|
Infection
|
|
Eugenitol (Compound 3) is an antifungal metabolite isolated and purified from Diaporthe eucalyptorum. Eugenitol has inhibitory effect on four plant pathogenic fungi (Alternaria solani, Botrytis cinerea, Fusarium solani and Gibberella saubinettii) .
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-
- HY-100513A
-
|
|
Apoptosis
DNA/RNA Synthesis
Antibiotic
|
Cancer
|
|
Dehydroaltenusin is a small molecule selective inhibitor of eukaryotic DNA polymerase α, a type of antibiotic produced by a fungus with an IC50 value of 0.68 μM. The inhibitory mode of action of dehydroaltenusin against mammalian pol α activity is competitive with respect to the DNA template primer (Ki=0.23 µM) and non-competitive with respect to the 2'-deoxyribonucleoside 5'-triphosphate substrate (Ki=0.18 µM) . Dehydroaltenusin arrests the cancer cell cycle at the S-phase and triggers apoptosis . Dehydroaltenusin possesses anti-tumor activity against human adenocarcinoma tumor in vivo .
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-
- HY-115407
-
|
|
Bacterial
|
Infection
Cancer
|
|
Cochliodone A is an active compound extracted from cultures of the deep-sea derived fungus Chaetomium sp. and has antibacterial and anticancer activity. Cochliodone A is toxic to a variety of bacteria, with MICs of 15.3 μg/mL (V. vulnificus), 32.7 μg/mL (V. rotiferianus), 15.9 μg/mL (S. aureus ATCC 43300), and 16.3 μg/mL (S . aureus CGMCC 1.12409). Cochliodone A also inhibits a variety of cancer cell lines, with IC50s of 28.1 μM (A549), 20.7 μM (HeLa), and 23.2 μM (Hep G2) .
|
-
| Cat. No. |
Product Name |
Type |
-
- HY-D0027
-
|
Coumarin 120; AMC
|
Fluorescent Dyes/Probes
|
|
7-Amino-4-methylcoumarin belongs to a group of coumarins. 7-Amino-4-methylcoumarin can be isolated from an endophytic fungus Xylaria sp., has broad antimicrobial activity. 7-Amino-4-methylcoumarin is additionally commonly used as an important laser dye emitting in the blue region, as well as a fluorescent probe enabling analyses of glycoproteins’ monosaccharides and N-linked oligosaccharides. The excitation wavelength and emission wavelength are 351 nm and 430 nm, respectively .
|
| Cat. No. |
Product Name |
Type |
-
- HY-W133982
-
|
|
Biochemical Assay Reagents
|
|
Corn steep liquor, a food industrial by-product, is a nutritional additive in the liquid culture medium of fungus. Corn steep liquor can increase the production of fairy chemicals and mycelia .
|
-
- HY-P2902
-
|
|
Biochemical Assay Reagents
|
|
Glucose oxidase is used in the food and beverage industry as a preservative and stabilizer and is commonly derived from the fungus Aspergillus niger. Glucose oxidase can react with intracellular glucose and oxygen (O2) to produce hydrogen peroxide (H2O2) and gluconic acid, which can cut off the nutrition source of cancer cells and consequently inhibit their proliferation .
|
-
- HY-157358
-
|
|
Microbial Culture
|
|
Corn Meal Medium is a special medium for fungus culture. The composition of 1 litre medium is 22 g Corn Meal Medium.
|
-
- HY-134181
-
|
Tremella polysaccharide
|
Biochemical Assay Reagents
|
|
Polysaccharidase (Tremella polysaccharide), one of the fungus polysaccharides, possesses immunity enhancing capabilities. Polysaccharidase has the potential for leukopenia induced by chemotherapy and radiotherapy research .
|
-
- HY-D0008
-
|
|
Biochemical Assay Reagents
|
|
Brilliant green is a cationic dye used to color silk and wool. Brilliant green inhibits propagation of mold, intestinal parasites and fungus. Brilliant green is effective against Gram-positive bacteria .
|
| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-N6689
-
|
|
Antibiotic
|
Infection
Cancer
|
|
Destruxin A (DA) is a cyclo-peptidic mycotoxin from the entomopathogenic fungus Metarhizium anisopliae, with insecticidal, anti-viral and antiproliferative activities .
|
-
- HY-133801
-
|
|
Peptides
|
Others
|
|
Unguisin A s a cyclic peptides that can be isolated from the marine-derived fungus Emericella unguis .
|
-
- HY-125488
-
|
|
Peptides
|
Others
|
|
Unguisin B s a cyclic peptides that can be isolated from the marine-derived fungus Emericella unguis .
|
-
- HY-P5647
-
|
|
Peptides
|
Infection
|
|
PhD1 is an antimicrobial peptide derived from monkey white blood cells. PhD1 has activity against bacteria and fungus Candida albicans .
|
-
- HY-P5648
-
|
|
Peptides
|
Infection
|
|
PhD2 is an antimicrobial peptide derived from monkey white blood cells. PhD2 has activity against bacteria and fungus Candida albicans .
|
-
- HY-P5649
-
|
|
Peptides
|
Infection
|
|
PhD3 is an antimicrobial peptide derived from monkey white blood cells. PhD3 has activity against bacteria and fungus Candida albicans .
|
-
- HY-P5651
-
|
|
Peptides
|
Infection
|
|
PhD4 is an antimicrobial peptide derived from monkey white blood cells. PhD4 has activity against bacteria and fungus Candida albicans .
|
-
- HY-P1508
-
|
Bactenecin, bovine
|
Bacterial
Fungal
Antibiotic
|
Infection
|
|
Bactenecin (Bactenecin, bovine) is a potent 12-aa looped antimicrobial peptide isolated from bovine neutrophils. Bactenecin inhibits the growth of bacteria and yeast, and kills the fungus Trichophyton rubrum. Bactenecin increass membrane permeability, inhibits the growth and biofilm formation of B. pseudomallei .
|
-
- HY-P1508A
-
|
Bactenecin, bovine TFA
|
Bacterial
Fungal
|
Infection
|
|
Bactenecin TFA (Bactenecin, bovine TFA) is a potent 12-aa looped antimicrobial peptide isolated from bovine neutrophils. Bactenecin TFA inhibits the growth of bacteria and yeast, and kills the fungus Trichophyton rubrum. Bactenecin TFA increass membrane permeability, inhibits the growth and biofilm formation of B. pseudomallei .
|
-
- HY-126810A
-
|
|
Fungal
|
Infection
|
|
NP213 TFA is a rapidly acting, novel, first-in-class synthetic antimicrobial peptide (AMP), has anti-fungal activities. NP213 TFA targets the fungal cytoplasmic membrane and plays it role via membrane perturbation and disruption. NP213 TFA is effective and well-tolerated in resolving nail fungal infections .
|
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
- HY-129515
-
-
- HY-125298
-
-
- HY-N12184
-
-
- HY-N2990
-
-
- HY-125666
-
-
- HY-N10241
-
-
- HY-113972
-
-
- HY-N3290
-
-
- HY-N12193
-
-
- HY-125706
-
-
- HY-N10427
-
-
- HY-N12194
-
-
- HY-N7023
-
-
- HY-N8571
-
-
- HY-N6689
-
-
- HY-138098
-
-
- HY-N6793
-
-
- HY-N10200
-
-
- HY-N10262
-
-
- HY-N2997
-
-
- HY-N9312
-
-
- HY-N12118
-
-
- HY-N9350
-
-
- HY-N9599
-
-
- HY-N10289
-
-
- HY-N8443
-
-
- HY-N4116
-
-
- HY-119821
-
-
- HY-W006429
-
-
- HY-N7151
-
-
- HY-N8520
-
-
- HY-N7435
-
-
- HY-126597
-
-
- HY-N12195
-
-
- HY-N3502
-
-
- HY-N10332
-
-
- HY-N12179
-
-
- HY-N8498
-
-
- HY-116474
-
-
- HY-N8511
-
-
- HY-75564
-
-
- HY-N6181
-
-
- HY-N8406
-
|
|
Microorganisms
Source classification
Phenols
|
Bacterial
Antibiotic
|
|
Monomethylsulochrin is a potent antibacterial metabolite from endophytic fungus Aspergillus fumigatus, isolated from Albizia lucidior leaves (fabaceae). Monomethylsulochrin exhibits anti-Staphylococcus aureus activity with minimum inhibitory concentration (MIC) of 31.25 μg/mL .
|
-
- HY-B0751
-
-
- HY-N10229
-
-
- HY-119458
-
-
- HY-B1350A
-
-
- HY-B1350
-
-
- HY-N8105
-
-
- HY-N8908
-
-
- HY-A0210
-
-
- HY-N10184
-
-
- HY-N10280
-
-
- HY-N12266
-
-
- HY-12361
-
-
- HY-P1508
-
-
- HY-W663230
-
-
- HY-N10281
-
-
- HY-N10502
-
-
- HY-N8537
-
-
- HY-118736
-
-
- HY-P1508A
-
-
- HY-133537
-
-
- HY-156241
-
-
- HY-N10288
-
-
- HY-N7731
-
-
- HY-N9003
-
-
- HY-142088
-
-
- HY-N12177
-
-
- HY-B1350R
-
-
- HY-N12386
-
-
- HY-N12726
-
-
- HY-N7307
-
-
- HY-N3570
-
-
- HY-N6690
-
-
- HY-N10113
-
-
- HY-N12198
-
|
|
Structural Classification
Natural Products
Microorganisms
Source classification
|
Others
|
|
Mollicellin H is a secondary metabolite of the fungus C. brasiliense and has a wide range of biological activities, including immunomodulation, cytotoxicity and anti-tumor effects. The growth inhibitory effects (GI50s) of Mollicellin H on human breast cancer (Bre04), human lung (Lu04) and human neuroma (N04) cell lines are 5.1 μg/mL, 6.5 μg/mL and 2.5 μg/mL respectively .
|
-
- HY-N10286
-
-
- HY-N12561
-
|
|
Structural Classification
Microorganisms
Terpenoids
Source classification
Diterpenoids
|
ERK
p38 MAPK
JNK
|
|
Pestanoid A is a rearranged pimarane diterpenoid osteoclastogenesis inhibitor with an IC50 of 4.2 μM. Pestanoid A can be isolated from the marine mesophotic zone chalinidae sponge-associated fungus, Pestalotiopsis sp. NBUF145. Pestanoid A inhibits the receptor activator of NF-kB ligand-induced MAPK and NF-κB signaling by suppressing the phosphorylation of ERK1/2-JNK1/2-p38 MAPKs and NF-κB nuclear translocation. Pestanoid A can be used for the study of osteoporosis .
|
-
- HY-N6682
-
-
- HY-N6711
-
-
- HY-N7432
-
-
- HY-121197
-
|
Ophiocordin; Azepinostatin
|
Structural Classification
Natural Products
Microorganisms
Source classification
|
PKA
PKC
|
|
Balanol (Ophiocordin; Azepinostatin) is a potent and ATP competitive PKC/PKA inhibitor against human PKC isozymes α, β-I, β-II, γ, δ, ε, η (IC50s=4-9 nM) and ζ (IC50=150 nM). Balanol also blocks the phosphorylation of cyclic AMP response element-binding protein (CREB) and myristoylated alanine-rich C kinase substrate (MARCKS). Balanol can be isolated from the fungus Verticillium balanoides .
|
-
- HY-N1964R
-
-
- HY-N11528
-
-
- HY-100513A
-
-
- HY-115407
-
|
|
Structural Classification
Natural Products
Microorganisms
Source classification
|
Bacterial
|
|
Cochliodone A is an active compound extracted from cultures of the deep-sea derived fungus Chaetomium sp. and has antibacterial and anticancer activity. Cochliodone A is toxic to a variety of bacteria, with MICs of 15.3 μg/mL (V. vulnificus), 32.7 μg/mL (V. rotiferianus), 15.9 μg/mL (S. aureus ATCC 43300), and 16.3 μg/mL (S . aureus CGMCC 1.12409). Cochliodone A also inhibits a variety of cancer cell lines, with IC50s of 28.1 μM (A549), 20.7 μM (HeLa), and 23.2 μM (Hep G2) .
|
-
| Cat. No. |
Product Name |
Chemical Structure |
-
- HY-B1350S
-
|
|
|
Fusidic acid-d6 is the deuterium labeled Fusidic acid. Fusidic acid (Fusidate) a bacteriostatic antibiotic produced from the Fusidium coccineum fungus, belongs to the class of steroids. Fusidic acid has no corticosteroid effects. Fusidic acid inhibits the growth of bacteria by preventing the release of translation elongation factor G (EF-G) from the ribosome[1][2].
|
-
-
- HY-B1290S
-
|
|
|
2-Phenylethanol-d4 is the deuterium labeled 2-Phenylethanol[1]. 2-Phenylethanol (Phenethyl alcohol), extracted from rose, carnation, hyacinth, Aleppo pine, orange blossom and other organisms, is a colourless liquid. It has a pleasant floral odor and also an autoantibiotic produced by the fungus Candida albicans[2]. It is used as an additive in cigarettes and also used as a preservative in soaps due to its stability in basic conditions.
|
-
-
- HY-B1290S1
-
|
|
|
2-Phenylethanol-d9 is the deuterium labeled 2-Phenylethanol[1]. 2-Phenylethanol (Phenethyl alcohol), extracted from rose, carnation, hyacinth, Aleppo pine, orange blossom and other organisms, is a colourless liquid. It has a pleasant floral odor and also an autoantibiotic produced by the fungus Candida albicans[2]. It is used as an additive in cigarettes and also used as a preservative in soaps due to its stability in basic conditions.
|
-
-
- HY-B1290S2
-
|
|
|
2-Phenylethanol-d5 is the deuterium labeled 2-Phenylethanol[1]. 2-Phenylethanol (Phenethyl alcohol), extracted from rose, carnation, hyacinth, Aleppo pine, orange blossom and other organisms, is a colourless liquid. It has a pleasant floral odor and also an autoantibiotic produced by the fungus Candida albicans[2]. It is used as an additive in cigarettes and also used as a preservative in soaps due to its stability in basic conditions.
|
-
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