Cat. No.: HY-N4116

Xanthyletin

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Based on 1 Customer Validation

Xanthyletin is a coumarin isolated from Stauranthus perforatus, with anti-tumor and anti-bacterial activities. Xanthyletin also inhibits symbiotic fungus cultivated by leaf-cutting ants.

For research use only. We do not sell to patients.

Purity: 98.87%
CAS No.: 553-19-5
Formula: C₁₄H₁₂O₃
Molecular Weight:228.24

Storage:

-20°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Xanthyletin Chemical Structure

CAS No.: 553-19-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

Xanthyletin is a coumarin isolated from Stauranthus perforatus, with anti-tumor and anti-bacterial activities. Xanthyletin also inhibits symbiotic fungus cultivated by leaf-cutting ants^[1].

IC₅₀ & Target

Fugal^[1]^[2]

Cellular Effect

Cell Line	Type	Value	Description	References
BXPC-3	GI₅₀	5.5 μg/mL Compound: 3	Cytotoxicity against human BxPC3 cells Cytotoxicity against human BxPC3 cells	[PMID: 15217278]
DU-145	GI₅₀	2.9 μg/mL Compound: 3	Cytotoxicity against human DU145 cells Cytotoxicity against human DU145 cells	[PMID: 15217278]
KM-20L2	GI₅₀	6.3 μg/mL Compound: 3	Cytotoxicity against human KM20L2 cells Cytotoxicity against human KM20L2 cells	[PMID: 15217278]
MCF7	GI₅₀	5.9 μg/mL Compound: 3	Cytotoxicity against human MCF7 cells Cytotoxicity against human MCF7 cells	[PMID: 15217278]
NCI-H460	GI₅₀	9 μg/mL Compound: 3	Cytotoxicity against human NCI-H460 cells Cytotoxicity against human NCI-H460 cells	[PMID: 15217278]
Neutrophil	IC₅₀	4.1 μg/mL Compound: Xanthyletin	Antiinflammatory activity against human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation Antiinflammatory activity against human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation	[PMID: 19128011]
Neutrophil	IC₅₀	5.53 μg/mL Compound: Xanthyletin	Antiinflammatory activity against human neutrophils assessed as inhibition of fMLP/CB-induced elastase release Antiinflammatory activity against human neutrophils assessed as inhibition of fMLP/CB-induced elastase release	[PMID: 19128011]
P388	GI₅₀	>10 μg/mL Compound: 3	Cytotoxicity against mouse P388 cells Cytotoxicity against mouse P388 cells	[PMID: 15217278]
SF-268	GI₅₀	11.2 μg/mL Compound: 3	Cytotoxicity against human SF268 cells Cytotoxicity against human SF268 cells	[PMID: 15217278]
SH-SY5Y	EC₅₀	8 μM Compound: 26	Neuroprotective activity in human SH-SY5Y cells assessed as reduction in 6-OHDA-induced cell death measured after 24 hrs by MTT assay Neuroprotective activity in human SH-SY5Y cells assessed as reduction in 6-OHDA-induced cell death measured after 24 hrs by MTT assay	[PMID: 27420919]
Vero	IC₅₀	>20 μg/mL Compound: 11	Cytotoxicity against african green monkey Vero cells after 7 days by XTT assay Cytotoxicity against african green monkey Vero cells after 7 days by XTT assay	[PMID: 8021652]

In Vitro

Xanthyletin inhibits symbiotic fungus cultivated by leaf-cutting ants^[1].
Xanthyletin (25, 50, and 100 μg/mL) shows a total inhibition on the fungus^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 553-19-5
Appearance Solid
Molecular Weight 228.24
Formula C₁₄H₁₂O₃
Color White to off-white
SMILES

O=C(O1)C=CC(C1=C2)=CC3=C2OC(C)(C)C=C3
Structure Classification
- Phenylpropanoids
- Coumarins
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (109.53 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.3814 mL

21.9068 mL

43.8135 mL

5 mM

0.8763 mL

4.3814 mL

8.7627 mL

10 mM

0.4381 mL

2.1907 mL

4.3814 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 1.25 mg/mL (5.48 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 1.25 mg/mL (5.48 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Cazal Cde M, et al. Isolation of xanthyletin, an inhibitor of ants' symbiotic fungus, by high-speed counter-current chromatography. J Chromatogr A. 2009 May 8;1216(19):4307-12. [Content Brief]

[2]. Marizete F. P. Godoy, et al. Inhibition of the symbiotic fungus of leaf-cutting ants by coumarins. J. Braz. Chem. Soc., 16 (2005), p. 669.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.3814 mL	21.9068 mL	43.8135 mL	109.5338 mL
	5 mM	0.8763 mL	4.3814 mL	8.7627 mL	21.9068 mL
	10 mM	0.4381 mL	2.1907 mL	4.3814 mL	10.9534 mL
	15 mM	0.2921 mL	1.4605 mL	2.9209 mL	7.3023 mL
	20 mM	0.2191 mL	1.0953 mL	2.1907 mL	5.4767 mL
	25 mM	0.1753 mL	0.8763 mL	1.7525 mL	4.3814 mL
	30 mM	0.1460 mL	0.7302 mL	1.4605 mL	3.6511 mL
	40 mM	0.1095 mL	0.5477 mL	1.0953 mL	2.7383 mL
	50 mM	0.0876 mL	0.4381 mL	0.8763 mL	2.1907 mL
	60 mM	0.0730 mL	0.3651 mL	0.7302 mL	1.8256 mL
	80 mM	0.0548 mL	0.2738 mL	0.5477 mL	1.3692 mL
	100 mM	0.0438 mL	0.2191 mL	0.4381 mL	1.0953 mL

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Xanthyletin

MCE Bioactive Compound Library

Natural Product Library Plus

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Xanthyletin

MCE Bioactive Compound Library

Natural Product Library Plus

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Xanthyletin Related Classifications

Cat. No.: HY-N4116