1. Metabolic Enzyme/Protease
    Anti-infection
  2. Cytochrome P450
    Fungal
  3. Inz-1

Inz-1 

Cat. No.: HY-116686
Handling Instructions

Inz-1 is a potent and selective mitochondrial cytochrome bc1 inhibitor for yeast (IC50=8.092 μM) over humans (IC50=45.320 μM). Inz-1 reverses Fluconazole (HY-B0101) or other triazole antifungals’ resistance in the pathogenic fungus Candida albicans.

For research use only. We do not sell to patients.

Inz-1 Chemical Structure

Inz-1 Chemical Structure

CAS No. : 897776-15-7

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Description

Inz-1 is a potent and selective mitochondrial cytochrome bc1 inhibitor for yeast (IC50=8.092 μM) over humans (IC50=45.320 μM). Inz-1 reverses Fluconazole (HY-B0101) or other triazole antifungals’ resistance in the pathogenic fungus Candida albicans[1].

IC50 & Target

IC50: 8.092 μM (yeast mitochondrial cytochrome bc1)
IC50: 45.320 μM (human mitochondrial cytochrome bc1)[1]

In Vitro

Inz-1 (0-16 μM; 24 hours) inhibits the growth of the model yeast S. cerevisiae (strain BY4741) and C. albicans (SC5314) in media containing glucose or glycerol as the sole carbon source, while only mildly slowing growth in glucose[1]
Inz-1 (0-100 μM; 24 hours) shows inhibition of yeast cytochrome B enzymatic activity in a concentration -dependent manner in both wild-type and F90Y mutant mitochondria. It exhibits inhibition of cytochrome bc1 from both S. cerevisiae and C. albicans with IC50 value of 2.5 μM and 8.0 μM, respectively[1].
Inz-1 (0-100 μM; 24 hours) is selective for yeast over human cytochrome bc1, it inhibits human cytochrome bc1 activity only weakly, with an IC50 of 45.3 μM, 5.6-fold higher than the IC50 for the C. albicans homolog in mitochondria purified from HEK293 human embryonic kidney cells[1].
Inz-1 (0-100 μM; 24 hours) inhibits proliferation under forced respiration conditions only at 32 μM,and only mildly at that concentration[1].
Inz-1 is against candida, human enzyme with IC50 values of 8.092 μM and 45.320 μM, respectively. It against Candida and HepG2 respiring growth with IC50 values of 1.655 uM and >32 μM, respectively[1].

Molecular Weight

266.29

Formula

C₁₆H₁₄N₂O₂

CAS No.

897776-15-7

SMILES

O=C(OC)CN1N=C(C2=CC=CC=C2)C3=C1C=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Inz-1Inz1Inz 1Cytochrome P450FungalCYPsfungalcellyeastFluconazoledrug-resistanceCandida albicansantifungalCytochrome Bc 1Inhibitorinhibitorinhibit

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