Harzianum A
Based on 1 Customer Validation
Harzianum A is a trichothecene compound. Harzianum A has no antibacterial activity against Gram-negative and Gram-positive bacteria, but has antifungal activity. In addition, Harzianum A is cytotoxic to tumor cells.
For research use only. We do not sell to patients.
- Purity: 95.0%
- CAS No.: 156250-74-7
- Formula: C23H28O6
- Molecular Weight:400.46
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Harzianum A (20-1000 μg/mL; 24 h) has no antibacterial activity against E. coli, B. subtilis, M. luteus and S. aureus at 1 mg/mL, but has antifungal activity against C. albicans and S. cerevisiae at 100 μg/mL[1].
Harzianum A (24 h) is cytotoxic to tumor cells with IC50 of 0.65 μg/mL for HT1080, 5.07 μg/mL for HeLa and 10.13 μg/mL for MCF-7, respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 156250-74-7
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Appearance Solid
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Molecular Weight 400.46
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Formula C23H28O6
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Color White to light yellow
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SMILES
C[C@@]12[C@]3(CO3)[C@H](O[C@@]4([H])[C@@]2(CCC(C)=C4)C)C[C@H]1OC(/C=C\C=C\C=C\C(O)=O)=O
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Structure Classification
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Initial Source
Trichoderma harzianum
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 10 mg/mL (24.97 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. D G Corley, et al. Isolation and structure of harzianum A: a new trichothecene from Trichoderma harzianum. J Nat Prod. 1994 Mar;57(3):422-5. [Content Brief]
[2]. Lee HB, et al. A new Hypocrea strain producing harzianum A cytotoxic to tumour cell lines. Lett Appl Microbiol. 2005;40(6):497-503. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4971 mL | 12.4856 mL | 24.9713 mL | 62.4282 mL |
| 5 mM | 0.4994 mL | 2.4971 mL | 4.9943 mL | 12.4856 mL | |
| 10 mM | 0.2497 mL | 1.2486 mL | 2.4971 mL | 6.2428 mL | |
| 15 mM | 0.1665 mL | 0.8324 mL | 1.6648 mL | 4.1619 mL | |
| 20 mM | 0.1249 mL | 0.6243 mL | 1.2486 mL | 3.1214 mL |
Harzianum A Related Classifications
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