FR-901235
FR-901235 is a new type of immunoactive substance produced by an imperfect fungus, Paecilomyces carneus F-4882. FR-901235 partially restored the impaired delayed-type hypersensitivity to sheep red blood cells in tumor-bearing mice.
For research use only. We do not sell to patients.
- CAS No.: 124190-19-8
- Formula: C18H16O7
- Molecular Weight:344.32
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MDA-MB-231 | IC50 |
>20 μM
Compound: 6; FR-901235
|
Cytotoxicity against human MDA-MB-231 cells by Celltiter-Glo assay
Cytotoxicity against human MDA-MB-231 cells by Celltiter-Glo assay
|
[PMID: 28657331] |
| MDA-MB-453 | IC50 |
>20 μM
Compound: 6; FR-901235
|
Cytotoxicity against human MDA-MB-453 cells by Celltiter-Glo assay
Cytotoxicity against human MDA-MB-453 cells by Celltiter-Glo assay
|
[PMID: 28657331] |
Chemical Information
-
CAS No. 124190-19-8
-
Molecular Weight 344.32
-
Formula C18H16O7
-
SMILES
O=C1C(CC(C)=O)(O)C(C2=C3C1=C(O)C=C(C)C3=C(OC)C=C2O)=O
-
Structure Classification
-
Initial Source
Paecilomyces carneus F-4882
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
-
Contact Hypersensitivity Dermatitis
Contact hypersensitivity (CHS) dermatitis is a T cell-mediated delayed-type (Type IV) immune reaction in which low-molecular-weight haptens applied to the skin bind host proteins to form complete antigens, triggering sensitization followed by a secondary inflammatory response upon re-exposure (elicitation phase), which is commonly quantified by ear swelling as a readout of skin inflammation in murine models. This model is widely used to study allergic contact dermatitis because it is antigen-specific, reproducible, and reflects key immunological events including dendritic cell activation, T cell priming in draining lymph nodes, and effector T cell-driven tissue inflammation. DNFB- and oxazolone-induced CHS models are standard systems for evaluating both acute and chronic T cell-dependent skin inflammation and for testing immunomodulatory interventions.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FR-901235 Related Classifications
HY-121431 Related Classifications
Powered by Bioz