A new immunomodulator, FR-901235

  • J Antibiot (Tokyo). 1989 Sep;42(9):1356-61. doi: 10.7164/antibiotics.42.1356.
T Shibata  1 ,  M Nishikawa ,  Y Tsurumi ,  S Takase ,  H Terano ,  M Kohsaka
Affiliations
  • 1. Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.
PMID: 2793590 DOI: 10.7164/antibiotics.42.1356
Abstract

FR-901235 is a new type of immunoactive substance produced by an imperfect fungus, Paecilomyces carneus F-4882. The mitogen-induced lymphocyte proliferation which had been suppressed by addition of immunosuppressive factor, was restored to a normal level by the addition of FR-901235. Furthermore, the subsequent administration of FR-901235 partially restored the impaired delayed-type hypersensitivity to sheep red blood cells in tumor-bearing mice.

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