Cytochalasin H
Based on 1 Customer Validation
Cytochalasin H is a nature product that could be isolated from fungus Phomopsis sp. Cytochalasin H inhibits cell growth and induces apoptosis. Cytochalasin H has anti-angiogenic activity. Cytochalasin H is an antibiotic and has antibacterial activity.
For research use only. We do not sell to patients.
- Purity: 99.40%
- CAS No.: 53760-19-3
- Formula: C30H39NO5
- Molecular Weight:493.63
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Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>50 μM
Compound: 18
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Cytotoxicity against human A549 cells measured after 72 hrs by MTT assay
Cytotoxicity against human A549 cells measured after 72 hrs by MTT assay
|
[PMID: 35473314] |
| HepG2 | IC50 |
>50 μM
Compound: 18
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Cytotoxicity against human HepG2 cells measured after 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells measured after 72 hrs by MTT assay
|
[PMID: 35473314] |
| MDA-MB-231 | IC50 |
42 μM
Compound: 18
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Cytotoxicity against human MDA-MB-231 cells measured after 72 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells measured after 72 hrs by MTT assay
|
[PMID: 35473314] |
| MDA-MB-435 | IC50 |
0.2 μM
Compound: 18
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Cytotoxicity against human MDA-MB-435 cells measured after 72 hrs by MTT assay
Cytotoxicity against human MDA-MB-435 cells measured after 72 hrs by MTT assay
|
[PMID: 35473314] |
| SNB-19 | IC50 |
26 μM
Compound: 18
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Cytotoxicity against human SNB-19 cells measured after 72 hrs by MTT assay
Cytotoxicity against human SNB-19 cells measured after 72 hrs by MTT assay
|
[PMID: 35473314] |
| Vero | IC50 |
40 μM
Compound: 18
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Cytotoxicity against African green monkey Vero cells measured after 72 hrs by MTT assay
Cytotoxicity against African green monkey Vero cells measured after 72 hrs by MTT assay
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[PMID: 35473314] |
Cytochalasin H (24-72 h) inhibits the proliferation of A549 cells with an IC50 value of 159.5 µM[1].
Cytochalasin H (0-50 µM; 48 h) induces apoptosis, arrests cell cycle at the G2/M phase and affects expression of apoptosis-related proteins in A549 cells[1].
Cytochalasin H (1-512 μg/mL) has antibacterial activity against MDR entero-pathogenic bacteria, Gram-positive bacterium, Staphylococcus aureus[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549 cells
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Concentration:0, 6.25, 12.5, 25 and 50 µM
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Incubation Time:48 h
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Result:Induced apoptosis in a dose-dependent manner in the A549 cells.
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Cell Line:A549 cells
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Concentration:0, 6.25, 12.5, 25 and 50 µM
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Incubation Time:48 h
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Result:Arrested cell cycle at the G2/M phase and sub-G1 peaks.
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Cell Line:A549 cells
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Concentration:0, 6.25, 12.5, 25 and 50 µM
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Incubation Time:48 h
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Result:Increased the protein expression levels of Bax, P53 and cleaved caspase-3 and decreased the protein expression levels of Bcl-xL, Bcl-2 and full-length caspase-3.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:male Balb/cnu/nu mice with A549 xenograft[2]
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Dosage:2.5 mg/kg
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Administration:intraperitoneal injection; 3 injections/week,for 80 days
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Result:Attenuated tumor growth in vivo.
Chemical Information
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CAS No. 53760-19-3
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Appearance Solid
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Molecular Weight 493.63
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Formula C30H39NO5
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Color White to off-white
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SMILES
O=C([C@@]12[C@](/C=C/C[C@H](C)C[C@@](C)(O)/C=C/[C@H]2OC(C)=O)([H])[C@@H]3O)N[C@@H](CC4=CC=CC=C4)[C@]1([H])[C@H](C)C3=C
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Purity & Documentation
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Data Sheet (281 KB)
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SDS (645 KB)
- English - EN (645 KB)
- Français - FR (645 KB)
- Deutsch - DE (645 KB)
- Norwegian - NO (645 KB)
- Español - ES (645 KB)
- Swedish - SV (645 KB)
- Italian - IT (645 KB)
- Portuguese - PT (645 KB)
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Handling Instructions (2659 KB)
References
[1]. Ma Y, et, al. Cytochalasin H isolated from mangrove‑derived endophytic fungus induces apoptosis and inhibits migration in lung cancer cells. Oncol Rep. 2018 Jun;39(6):2899-2905. [Content Brief]
[2]. Yi JM, et, al. In Vivo Anti-tumor Effects of the Ethanol Extract of Gleditsia sinensis Thorns and Its Active Constituent, Cytochalasin H. Biol Pharm Bull. 2015;38(6):909-12. [Content Brief]
[3]. Jouda JB, et, al. Antibacterial and cytotoxic cytochalasins from the endophytic fungus Phomopsis sp. harbored in Garcinia kola (Heckel) nut. BMC Complement Altern Med. 2016 Nov 14;16(1):462. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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