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  2. Fungal
  3. Enfumafungin

Enfumafungin 

Cat. No.: HY-N8537
Handling Instructions

Enfumafungin, a triterpene glycoside, is isolated from extracts derived from an endophytic species of Hormonema. Enfumafungin is an antifungal compound that is acting on the fungal cell wall, as the (1,3)-beta-D-glucan synthase inhibitor. Enfumafungin is specific for yeasts and fungi (excluding Cryptococcus) and does not inhibit the growth of Bacillus subtilis.

For research use only. We do not sell to patients.

Enfumafungin Chemical Structure

Enfumafungin Chemical Structure

CAS No. : 260979-95-1

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Description

Enfumafungin, a triterpene glycoside, is isolated from extracts derived from an endophytic species of Hormonema. Enfumafungin is an antifungal compound that is acting on the fungal cell wall, as the (1,3)-beta-D-glucan synthase inhibitor. Enfumafungin is specific for yeasts and fungi (excluding Cryptococcus) and does not inhibit the growth of Bacillus subtilis[1][2].

IC50 & Target

(1,3)-beta-D-glucan synthase[1]

In Vitro

Enfumafungin (24-48 h) has MICs of less than 0.5 μg/mL against the Candida and Aspergillus species tested and it is inactive against Cryptococcus, including the decapsulated form (MY2062)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Enfumafungin (50-200 mg/kg; i.p. twice daily for 2 days) produces a significant decrease in the number of c.f.u. in kidneys of mice challenged with C. albicans, with an ED90 of 90 mg/kg[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

708.88

Formula

C₃₈H₆₀O₁₂

CAS No.

260979-95-1

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

EnfumafunginFungaltriterpeneglycosideantifungalglucansynthaseyeastsfungiInhibitorinhibitorinhibit

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Enfumafungin
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