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Results for "

Helicase Inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (4) Apoptosis (9) ATM/ATR (1) Autophagy (1) Bacterial (4) Cholinesterase (ChE) (2) CMV (1) Cyclic GMP-AMP Synthase (1) Cytochrome P450 (1) Dengue Virus (1) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (104) Endogenous Metabolite (2) Eukaryotic Initiation Factor (eIF) (2) Ferroptosis (1) Filovirus (1) Flavivirus (1) G-quadruplex (2) GLUT (4) HCV (7) HCV Protease (1) HSV (17) Isotope-Labeled Compounds (4) PAK (1) Phosphatase (1) Reactive Oxygen Species (ROS) (4) Reference Standards (9) SARS-CoV (10) STING (1) TMV (1) Topoisomerase (1) Virus Protease (2)
By Research Areas:	Cancer (82) Cardiovascular Disease (2) Infection (42) Inflammation/Immunology (5) Metabolic Disease (4)

By Targets:

Akt (4)

Apoptosis (9)

ATM/ATR (1)

Autophagy (1)

Bacterial (4)

Cholinesterase (ChE) (2)

CMV (1)

Cyclic GMP-AMP Synthase (1)

Cytochrome P450 (1)

Dengue Virus (1)

DNA Alkylator/Crosslinker (1)

DNA/RNA Synthesis (104)

Endogenous Metabolite (2)

Eukaryotic Initiation Factor (eIF) (2)

Ferroptosis (1)

Filovirus (1)

Flavivirus (1)

G-quadruplex (2)

GLUT (4)

HCV (7)

HCV Protease (1)

HSV (17)

Isotope-Labeled Compounds (4)

PAK (1)

Phosphatase (1)

Reactive Oxygen Species (ROS) (4)

Reference Standards (9)

SARS-CoV (10)

STING (1)

TMV (1)

Topoisomerase (1)

Virus Protease (2)

By Research Areas:

Cancer (82)

Cardiovascular Disease (2)

Infection (42)

Inflammation/Immunology (5)

Metabolic Disease (4)

127

Inhibitors & Agonists

Fluorescent Dyes

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Serpin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-148699

HRO761 3 Publications Verification Werner syndrome RecQ Helicase-IN-1	DNA/RNA Synthesis	Cancer
HRO761 (Werner syndrome RecQ helicase-IN-1) (example 42) is a potent Werner syndrome RecQ DNA helicase enzyme (WRN) inhibitor and can be used in cancer research .

HY-158116

VVD-214 RO7589831; VVD-133214	DNA/RNA Synthesis	Cancer
VVD-214 is a synthetic lethal allosteric inhibitor of WRN helicase with an IC₅₀ of 0.1316 µM. VVD-214 covalently binds to cysteine 727 of WRN and inhibits ATP hydrolysis and *helicase* activity. VVD-214 is potent in causing double-stranded DNA breaks, nuclear swelling, and cell death in high microsatellite instability (MSI) cancers .

HY-14809

Amenamevir 5+ Cited Publications ASP2151	HSV	Infection
Amenamevir is a *helicase-primase* inhibitor which has potent antiviral activity against HSVs with an EC₅₀ of 14 ng/mL.

HY-15594A

Phen-DC3 Trifluoromethanesulfonate 5+ Cited Publications Phen-DC3 Triflate	G-quadruplex	Cancer
Phen-DC3 Trifluoromethanesulfonate is a G-quadruplex (G4) specific ligand which can inhibit FANCJ and DinG helicases with IC₅₀s of 65±6 and 50±10 nM, respectively.

HY-169422

GSK4418959 IDE275	DNA/RNA Synthesis	Cancer
GSK4418959 (IDE275) is a selective, reversible and orally active WRN helicase inhibitor. GSK4418959 shows >10,000-fold selectivity over other helicases. GSK4418959 inhibits ATPase and DNA unwinding functions in an ATP-competitive manner. GSK4418959 can be used for the study of microsatellite instability-high (MSI-H) cancer, such as colorectal cancer (CRC) and endometrial cancer (EC) .

HY-100455

RK-33 5 Publications Verification	DNA/RNA Synthesis SARS-CoV	Cancer
RK-33 is an RNA helicase inhibitor against DDX3, and inhibits its helicase activity.

HY-128729

DNA2 inhibitor C5 Maximum Cited Publications 10 Publications Verification	DNA/RNA Synthesis	Cancer
DNA2 inhibitor C5 is a potent, competitive, and specific DNA2 nuclease inhibitor with an IC₅₀ of 20 μM. DNA2 inhibitor C5 inhibits the nuclease, DNA-dependent ATPase, *helicase, and DNA-binding activities of DNA2. DNA2 inhibitor* C5 can be used in breast cancer and colorectal cancer research .

HY-12342

ML216 5+ Cited Publications CID-49852229	DNA/RNA Synthesis	Cancer
ML216 (CID-49852229) is a potent, selective and cell permeable inhibitor of the DNA unwinding activity of BLM helicase with IC₅₀s of 2.98 μM and 0.97 μM for BLM ^full-length and BLM ^636-1298, respectively. ML216 inhibits ssDNA-dependent ATPase activity of BLM with a K_i of 1.76 μM. Antitumor avtivity .

HY-150279

PolQi2 3 Publications Verification	DNA/RNA Synthesis	Others
PolQi2 is a PolΘ inhibitor that targets and inhibits alt-EJ (alternative end-joining) repair by inhibiting the helicase domain at the N-terminus of PolΘ. PolQi2 enhances the precision and integration efficiency of gene editing at different loci and in various cell lines. Furthermore, the combined use of PolQi2 with DNA-PK inhibitors reduces the off-target effects of Cas9. PolQi2 can be used in gene editing research .

HY-15303

Pritelivir 5+ Cited Publications AIC316; BAY 57-1293	DNA/RNA Synthesis HSV	Infection
Pritelivir (AIC316), an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. Pritelivir is active against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) with the IC₅₀ of 0.02 μM against HSV1-2 .

HY-110185

NSC 617145 3 Publications Verification	DNA/RNA Synthesis	Cancer
NSC 617145 is a selective werner syndrome helicase (WRN) helicase inhibitor with an IC₅₀ value of 230 nM. NSC 617145 inhibits WRN ATPase, and induces double-strand breaks (DSB) and chromosomal abnormalities. NSC 617145 shows selective for WRN over BLM, FANCJ, ChlR1, RecQ, and UvrD helicases .

HY-122903

TK216 5+ Cited Publications	DNA/RNA Synthesis	Cancer
TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor . TK216 directly binds EWS-FLI1 and inhibits EWS-FLI1 protein interactions. TK216 blocks the binding between EWS-FLI1 and RNA helicase A. TK216 has anticancer activity .

HY-175750

MOMA-341	DNA/RNA Synthesis	Cancer
MOMA-341 is a selective *Werner RecQ like helicase* (WRN)** inhibitor. MOMA-341 binds to WRN at cysteine 727 through an allosteric and ATP-competitive binding mechanism. MOMA-341 has antitumor activity and can be used for advanced and metastatic solid tumors research .

HY-148740

Werner syndrome RecQ helicase-IN-3	DNA/RNA Synthesis	Cancer
Werner syndrome RecQ helicase-IN-3 is a potent and orally active *werner syndrome recQ helicase* (WRN)** inhibitor with an IC₅₀ value of 0.06 µM. Werner syndrome RecQ helicase-IN-3 shows antiproliferative activity. Werner syndrome RecQ helicase-IN-3 shows anticancer activity .

HY-156418

KY386	DNA/RNA Synthesis Ferroptosis Apoptosis Reactive Oxygen Species (ROS)	Cancer
KY386 is a DHX33 helicase inhibitor with an IC₅₀ of 0.019 μM. KY386 inhibits the cell viability of various cancer cells. KY386 induces ferroptosis in cancer cells, and induces apoptosis in some cancer cell lines. KY386 increases the intracellular levels of ROS, LPO and Fe ²⁺, and decreases the level of GSH in cancer cells . KY386 inhibits the growth of gastric cancer and colon cancer xenografts in nude mice. KY386 is applicable to the related research on liver cancer, lung cancer, pancreatic cancer, colorectal cancer, gastric cancer, breast cancer, leukemia, renal cancer, prostate cancer, esophageal cancer, cervical cancer, brain cancer (glioblastoma) and melanoma .

HY-156782

DHX9-IN-1 1 Publications Verification	DNA/RNA Synthesis	Cancer
DHX9-IN-1 is an inhibitor of ATP-dependent RNA helicase A (DHX9). Its EC₅₀ value is 1.41 μM. DHX9-IN-1 has anti-tumor activity and can be used in colorectal cancer research .

HY-150306

Adibelivir IM-250	DNA/RNA Synthesis HSV	Infection
Adibelivir (IM-250) is an orally active *helicase-primase* inhibitor. Adibelivir is effective against HSV infection and reduces reactivation of latent HSV. Adibelivir inhibits HSV-1 infection in Vero cells (IC₅₀: ~20 nM). Adibelivir can be used for the study of recurrent herpes disease^[1][2]_.

HY-160007

DHX9-IN-3	DNA/RNA Synthesis	Cancer
DHX9-IN-3 (Compound 621) is an inhibitor of ATP-dependent RNA helicase A (DHX9). DHX9-IN-3 has an IC₅₀ of 8.7 nM for anti-proliferation in LS411N cells. DHX9-IN-3 can be used in the study of cancer .

HY-114977

Avenanthramide A	DNA/RNA Synthesis Apoptosis Reactive Oxygen Species (ROS)	Inflammation/Immunology Cancer
Avenanthramide A is an orally active phytoalexin that targets the RNA helicase DDX3 with a K_D of 8.8 μM. Avenanthramide A induces mitochondrial swelling and increased ROS production, and triggers apoptosis in CRC cells. Avenanthramide A inhibits smooth muscle cell proliferation and enhances nitric oxide production. Avenanthramide A can be used in research on colorectal cancer and atherosclerosis .

HY-162471

GSK_WRN3	DNA/RNA Synthesis ATM/ATR	Cancer
GSK_WRN3 is selective WRN helicase inhibitor (pIC₅₀ = 8.6). SK_WRN3 can selectively inhibit the growth of microsatellite unstable (MSI) cancer cells, induce DNA damage, and cause cell cycle arrest. GSK_WRN3 has anti-tumor activity .

HY-160009

DHX9-IN-5	DNA/RNA Synthesis	Cancer
DHX9-IN-5 (compound 277) is a *RNA helicase* DHX9** inhibitor with an IC₅₀ of 4.3 nM .

HY-157604

DHX9-IN-9	DNA/RNA Synthesis	Cancer
DHX9-IN-9 (509) is a RNA helicase DHX9 inhibitor, with an EC₅₀ of 0.0177 μM in DHX9 cellular target engagement. Used in cancer research .

HY-136638

ML328	DNA/RNA Synthesis Bacterial	Infection
ML328 is a selective inhibitor of bacterial AddAB and RecBCD helicase-nucleases with IC₅₀ values of 26 and 5.1 μM, respectively. ML328 is a gyrase inhibitor. ML328 strongly inhibits the growth of E. coli in the presence of phage. ML328 can be used for the research of bacterial infection .

HY-N6935

Sennidin B	DNA/RNA Synthesis HCV Akt GLUT	Infection Metabolic Disease
Sennidin B, a stereoisomer isolated from the leaves of Cassia angustifolia, has lower activity than Sennidin A. Sennidin A inhibits HCV NS3 helicase, with an IC₅₀ of 0.8 μM. Sennidin A induces phosphorylation of Akt and glucose transporter 4 (GLUT4) translocation. Sennidin A stimulates the glucose incorporation .

HY-128712

NCGC00029283	DNA/RNA Synthesis	Cancer
NCGC00029283 is a werner syndrome helicase-nuclease (WRN) helicase inhibitor with IC₅₀s of 2.3 μM, 12.5 μM, and 3.4 μM for WRN, BLM and FANCJ helicase, respectively .

HY-137820

Brr2-IN-3	DNA/RNA Synthesis	Others
Brr2-IN-3 is a potent and selective Brr2 helicase allosteric Inhibitor. Brr2-IN-3 inhibits helicase activity in dose-dependent manner with an IC₅₀ value of 1.3 μM .

HY-160859

WRN inhibitor 8	DNA/RNA Synthesis	Cancer
WRN inhibitor 8 is an inhibitor of WRN helicase with an IC₅₀ value of 48 nM. WRN inhibitor 8 can inhibit the proliferation of tumor cells and be used in the study of cancer .

HY-105387

Heliquinomycin	DNA/RNA Synthesis Bacterial Topoisomerase	Infection Cancer
Heliquinomycin is an inhibitor of DNA helicase (K_i: 6.8 μM) and inhibits DNA and RNA synthesis. Heliquinomycin is effective against Gram-positive bacteria strains. Heliquinomycin inhibits cancer cell growth .

HY-169422A

GSK4418959 (enantiomer) IDE275 (enantiomer)	DNA/RNA Synthesis	Cancer
GSK4418959 enantiomer is an enantiomer of GSK4418959 (HY-169422). GSK4418959 (IDE275) is a non-covalent, reversible, selective and orally active WRN helicase inhibitor. GSK4418959 inhibits ATPase and DNA unwinding functions in an ATP-competitive manner. GSK4418959 can be used for the study of microsatellite instability-high (MSI-H) cancer .

HY-148741

Werner syndrome RecQ helicase-IN-4	DNA/RNA Synthesis	Cancer
Werner syndrome RecQ helicase-IN-4 is a potent and orally active *werner syndrome recQ helicase* (WRN)** inhibitor with an IC₅₀ value of 0.06 µM. Werner syndrome RecQ helicase-IN-4 shows antiproliferative activity. Werner syndrome RecQ helicase-IN-4 shows anticancer activity .

HY-163529

HN0037	HSV Cytochrome P450	Infection
HN0037 is a selective, orally active *Helicase-primase* inhibitor. HN0037 is mainly metabolized by CYP3A4. HN0037 inhibits HSV replication by targeting the viral helicase-primase complex, which consists of three proteins encoded by UL5 (helicase), UL52 (primase), and UL8 (scaffold protein that promotes primer synthesis) .

HY-D0306

Tris(4-aminophenyl)methane Leucopararosaniline	DNA/RNA Synthesis HCV	Infection
Tris(4-aminophenyl)methane is a triphenylmethane dye. Tris(4-aminophenyl)methane is a weak HCV helicase inhibitor.

HY-173018

ML283	HCV Dengue Virus	Infection
ML283 is a HCV NS3 helicase inhibitor (IC₅₀: 2.6 μM). ML283 also inhibits DenV ATPase (IC₅₀: 4.0 μM) .

HY-15594

Phen-DC3	DNA/RNA Synthesis	Cancer
Phen-DC3 is a G-quadruplex (G4) specific ligand which can inhibit FANCJ and DinG helicases with IC₅₀s of 65±6 and 50±10 nM, respectively.

HY-176268

SGC-NSP2hel-1 RA-0188293; RA-NSP2-1	DNA/RNA Synthesis Virus Protease Flavivirus	Infection
SGC-NSP2hel-1 (RA-0188293), a chemical probe, is a potent, specific and orally active nsP2 inhibitor. SGC-NSP2hel-1 has broad spectrum activity against multiple alphaviruses of the nsP2 helicase with a CC₅₀ > 250 μM. SGC-NSP2hel-1 (RA-0188293) shows selectivity index > 4000 against human RNA helicases. SGC-NSP2hel-1 reduces virus replication and limited virus-induced pathology by forming a stable complex with nsP2 and ATP in a preclinical small animal model of CHIKV disease.

HY-153692

WRN inhibitor 1	DNA/RNA Synthesis	Cancer
WRN inhibitor 1 is a Wemer Syndrome ATP dependent helicase enzyme (WRN) inhibitor that inhibits WRN helicase domain activity. WRN inhibitor 1 can be used in the study of cancer .

HY-148700

Werner syndrome RecQ helicase-IN-2	DNA/RNA Synthesis	Cancer
Werner syndrome RecQ helicase-IN-2 (example 57) is a potent Werner syndrome RecQ DNA helicase enzyme (WRN) inhibitor and can be used in cancer research .

HY-144800

FWM-1	SARS-CoV	Infection
FWM-1 is a potent *SARS-COV-2 NSP13 helicase* enzyme** inhibitor with binding free energy equals -328.6 kcal/mol. FWM-1 effectively disrupts the binding of ATP to the SARS-COV2 helicase enzyme .

HY-156580

WRN inhibitor 4	DNA/RNA Synthesis	Cancer
WRN inhibitor 4 is a Werner Syndrome ATP-dependent helicase (WRN) inhibitor. WRN inhibitor 4 can be used for cancer research .

HY-156579

WRN inhibitor 3	DNA/RNA Synthesis	Cancer
WRN inhibitor 3 (example 110), a cyclic vinyl sulfone compound, is a Wemer Syndrome ATP dependent helicase enzyme (WRN) inhibitor. WRN inhibitor 3 can be used for the research of cancer .

HY-156581

WRN inhibitor 5	DNA/RNA Synthesis	Cancer
WRN inhibitor 5, a cyclic vinyl sulfone compound, is a *Wemer Syndrome ATP dependent helicase* enzyme (WRN)** inhibitor. WRN inhibitor 5 can be used for the research of cancer, including cancers characterized by microsatellite instability (MSI) and/or defective DNA mismatch repair system (dMMR) .

HY-15303B

Pritelivir mesylate hydrate 5+ Cited Publications AIC316 mesylate hydrate; BAY 57-1293 mesylate hydrate	DNA/RNA Synthesis HSV	Infection
Pritelivir mesylate hydrate (BAY 57-1293 mesylate hydrate), an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. Pritelivir mesylate hydrate is active against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) with the IC₅₀ of 0.02 μM against HSV1-2 .

HY-178991

WRN-IN-21	DNA/RNA Synthesis	Cancer
WRN-IN-21 (Compound 11b) is a WRN helicase inhibitor with pIC₅₀ values for WRN and BLM helicases of 3.6 and 5.4 respectively. WRN-IN-21 can be used for the study of MSI-related cancers .

HY-169423

WRN inhibitor 17	DNA/RNA Synthesis	Cancer
WRN inhibitor 17 (Compound 250) is an orally active Werner Syndrome ATP dependent helicase enzyme (WRN) inhibitor, in particular inhibit WRN helicase domain activity. WRN inhibitor 17 is promising for research of cancers .

HY-168592

WRN inhibitor 12	DNA/RNA Synthesis	Cancer
WRN inhibitor 12 (compound 5) is an inhibitor of WRN helicase .

HY-175012

PIF1-IN-1	DNA/RNA Synthesis	Others
PIF1-IN-1 (Compound 48) is an inhibitor of hPIF1 helicase (IC₅₀ = 320 μM) .

HY-153973

WRN inhibitor 2	DNA/RNA Synthesis	Cancer
WRN inhibitor 2 (example 118) is a WRN (Werner Syndrome ATP dependent helicase enzyme) inhibitor, with pIC₅₀ ≥ 7.0 .

HY-160010

DHX9-IN-6	DNA/RNA Synthesis	Cancer
DHX9-IN-6 (Compound 620) is an ATP-dependent inhibitor of RNA helicase A (DHX9) with potential for cancer research .

HY-160008

DHX9-IN-4	DNA/RNA Synthesis	Cancer
DHX9-IN-4 (Compound 609) is an ATP-dependent inhibitor of RNA helicase A (DHX9) with potential for cancer research .

HY-14809R

Amenamevir (Standard) ASP2151 (Standard)	Reference Standards HSV	Infection
Amenamevir (Standard) is the analytical standard of Amenamevir. This product is intended for research and analytical applications. Amenamevir is a *helicase-primase* inhibitor which has potent antiviral activity against HSVs with an EC₅₀ of 14 ng/mL.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-107825

Flavonol 2 Publications Verification	Flavonols Structural Classification Flavonoids Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Bacterial Cholinesterase (ChE)
Flavonol is a cholinesterase (ChE) inhibitor, with an IC₅₀ value of 120 μM and a K_i value of 74 μM. Flavonol has antioxidant, free radical-scavenging, antibacterial properties, and immune modulation functions. Flavonol inhibits the PriA helicase of Staphylococcus aureus. Flavonol can suppress the production of NO in LPS-activated RAW 264.7 cells by inhibiting the expression of the iNOS enzyme. Flavonol shows protective and analgesic effects in mice through various neuronal pathways. Flavonol can be used in research related to tumors and atherosclerosis diseases .

HY-114977

Avenanthramide A	Structural Classification Avena sativa Linn. Gramineae Phenols Polyphenols Plants Source Classification	DNA/RNA Synthesis Apoptosis Reactive Oxygen Species (ROS)
Avenanthramide A is an orally active phytoalexin that targets the RNA helicase DDX3 with a K_D of 8.8 μM. Avenanthramide A induces mitochondrial swelling and increased ROS production, and triggers apoptosis in CRC cells. Avenanthramide A inhibits smooth muscle cell proliferation and enhances nitric oxide production. Avenanthramide A can be used in research on colorectal cancer and atherosclerosis .

HY-N6935

Sennidin B	Structural Classification Classification of Application Fields Metabolic Disease Plants Infection other families Leguminosae Ketones, Aldehydes, Acids Phenols Polyphenols Cassia angustifolia Disease Research Fields Source Classification	DNA/RNA Synthesis HCV Akt GLUT
Sennidin B, a stereoisomer isolated from the leaves of Cassia angustifolia, has lower activity than Sennidin A. Sennidin A inhibits HCV NS3 helicase, with an IC₅₀ of 0.8 μM. Sennidin A induces phosphorylation of Akt and glucose transporter 4 (GLUT4) translocation. Sennidin A stimulates the glucose incorporation .

HY-N6936

Sennidin A	Infection Structural Classification other families Classification of Application Fields Ketones, Aldehydes, Acids Phenols Polyphenols Plants Disease Research Fields Source Classification	DNA/RNA Synthesis HCV Akt GLUT
Sennidin A, isolated from the leaves of Cassia angustifolia, inhibits HCV NS3 helicase, with an IC₅₀ of 0.8 μM. Sennidin A induces phosphorylation of Akt and glucose transporter 4 (GLUT4) translocation. Sennidin A stimulates the glucose incorporation .

HY-114977R

Avenanthramide A (Standard)	Structural Classification Avena sativa Linn. Gramineae Phenols Polyphenols Plants Source Classification	Reference Standards Apoptosis DNA/RNA Synthesis Reactive Oxygen Species (ROS)
Avenanthramide A (Standard) is the analytical standard of Avenanthramide A. This product is intended for research and analytical applications. Avenanthramide A is an orally active phytoalexin that targets the RNA helicase DDX3 with a K_D of 8.8 μM. Avenanthramide A induces mitochondrial swelling and increased ROS production, and triggers apoptosis in CRC cells. Avenanthramide A inhibits smooth muscle cell proliferation and enhances nitric oxide production. Avenanthramide A can be used in research on colorectal cancer and atherosclerosis .

HY-N14130

Cyclothialidine B	Structural Classification Microorganisms Phenols Polyphenols Source Classification	DNA/RNA Synthesis
Cyclothialidine B inhibits escherichia coli DNA helicases with an IC₅₀ of 0.7 μM .

HY-N14131

Cyclothialidine D	Structural Classification Microorganisms Phenols Polyphenols Source Classification	DNA/RNA Synthesis
Cyclothialidine D inhibits escherichia coli DNA helicases with an IC₅₀ of 0.7 μM .

HY-N14132

Cyclothialidine E	Structural Classification Microorganisms Phenols Polyphenols Source Classification	DNA/RNA Synthesis
Cyclothialidine E inhibits escherichia coli DNA helicases with an IC₅₀ of 0.7 μM .

HY-N6936R

Sennidin A (Standard)	other families Ketones, Aldehydes, Acids Phenols Polyphenols Plants Source Classification	Reference Standards HCV Akt GLUT
Sennidin A (Standard) is the analytical standard of Sennidin A. This product is intended for research and analytical applications. Sennidin A, isolated from the leaves of Cassia angustifolia, inhibits HCV NS3 helicase, with an IC50 of 0.8 μM. Sennidin A induces phosphorylation of Akt and glucose transporter 4 (GLUT4) translocation. Sennidin A stimulates the glucose incorporation .

HY-N6935R

Sennidin B (Standard)	other families Leguminosae Ketones, Aldehydes, Acids Phenols Polyphenols Cassia angustifolia Plants Source Classification	Reference Standards HCV Akt GLUT
Sennidin B (Standard) is the analytical standard of Sennidin B. This product is intended for research and analytical applications. Sennidin B, a stereoisomer isolated from the leaves of Cassia angustifolia, has lower activity than Sennidin A. Sennidin A inhibits HCV NS3 helicase, with an IC50 of 0.8 μM. Sennidin A induces phosphorylation of Akt and glucose transporter 4 (GLUT4) translocation. Sennidin A stimulates the glucose incorporation .

HY-107825R

Flavonol (Standard)	Flavonols Structural Classification Flavonoids Endogenous metabolite Source Classification	Endogenous Metabolite Bacterial Cholinesterase (ChE) Reference Standards
Flavonol (Standard) is the analytical standard of Flavonol. This product is intended for research and analytical applications. Flavonol is a cholinesterase (ChE) inhibitor, with an IC50 value of 120 μM and a Ki value of 74 μM. Flavonol has antioxidant, free radical-scavenging, antibacterial properties, and immune modulation functions. Flavonol inhibits the PriA helicase of Staphylococcus aureus. Flavonol can suppress the production of NO in LPS-activated RAW 264.7 cells by inhibiting the expression of the iNOS enzyme. Flavonol shows protective and analgesic effects in mice through various neuronal pathways. Flavonol can be used in research related to tumors and atherosclerosis diseases .

Cat. No.	Product Name	Chemical Structure

HY-122903S

TK216-d4
TK216-d₄ is the deuterium labeled TK216 (HY-122903). TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor . TK216 directly binds EWS-FLI1 and inhibits EWS-FLI1 protein interactions. TK216 blocks the binding between EWS-FLI1 and RNA helicase A. TK216 has anticancer activity .

HY-114977S

Avenanthramide A-d4

Avenanthramide A-d₄ is the deuterium labeled Avenanthramide A (HY-114977). Avenanthramide A is an orally active phytoalexin that targets the RNA helicase DDX3 with a K_D of 8.8 μM. Avenanthramide A induces mitochondrial swelling and increased ROS production, and triggers apoptosis in CRC cells. Avenanthramide A inhibits smooth muscle cell proliferation and enhances nitric oxide production. Avenanthramide A can be used in research on colorectal cancer and atherosclerosis .

HY-15303S

Pritelivir-d4-1
Pritelivir-d₄-1 (AIC316-d₄-1) is deuterium labeled Pritelivir. Pritelivir (AIC316), an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. Pritelivir is active against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) with the IC₅₀ of 0.02 μM against HSV1-2 .

HY-W752451

Amenamevir-d6
Amenamevir-d₆ (ASP2151-d₆) is the deuterium labeled Amenamevir (HY-14809). Amenamevir is a helicase-primase inhibitor which has potent antiviral activity against HSVs with an EC₅₀ of 14 ng/mL.

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