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Cat. No.: HY-182313

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WRN-IN-25

WRN-IN-25 is an allosteric Werner syndrome helicase (WRN) inhibitor with an IC₅₀ of 15 nM and a K_d of 54 nM. WRN-IN-25 induces DNA damage, reduces cell viability, and exhibits synthetic lethality in WRN-driven high microsatellite instability cancer cells. WRN-IN-25 can be used in research related to microsatellite instability cancers.

For research use only. We do not sell to patients.

Formula: C₃₃H₃₈F₂N₄O₄
Molecular Weight:592.68

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

WRN-IN-25 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

Helicase

All DNA/RNA Synthesis Isoforms :

In Vitro

WRN-IN-25 (Compound (AC2) (20 μmol/L top concentration, 1:2 serial dilutions; 72 h) shows that HCT116 cells with WRN^I852F mutations are resistant to WRN-IN-25, with WRN-IN-25 inhibiting mutant WRN helicase-mediated DNA unwinding with an IC₅₀ of 312 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 592.68
Formula C₃₃H₃₈F₂N₄O₄
SMILES

O=C(O)CC[C@H](C1=CC=CC=C1)OC2=NC(N3CCN(C(C4=CC=C(C(C)C)C=C4)=O)[C@H](C)C3)=CC(N5CC(F)(F)C5)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Fowler F, et al. Microsatellite instable cancer cells acquire on-target resistance mutations to WRN helicase inhibitors. Mol Cancer Ther. Published online February 9, 2026. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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WRN-IN-25

All DNA/RNA Synthesis Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

WRN-IN-25 Related Classifications

HY-182313 Related Classifications