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Cat. No.: HY-168583

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WRN inhibitor 11

WRN inhibitor 11 (Example 17) is an orally active inhibitor of WRN helicase, with the IC₅₀ of 63 nM.

For research use only. We do not sell to patients.

CAS No.: 3058317-61-3
Formula: C₃₄H₃₅ClF₃N₉O₅
Molecular Weight:742.15

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

WRN inhibitor 11 Chemical Structure

CAS No.: 3058317-61-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

WRN inhibitor 11 (Example 17) is an orally active inhibitor of WRN helicase, with the IC₅₀ of 63 nM^[1].

IC₅₀ & Target

Helicase

All DNA/RNA Synthesis Isoforms :

Chemical Information

CAS No. 3058317-61-3
Molecular Weight 742.15
Formula C₃₄H₃₅ClF₃N₉O₅
SMILES

CCC1=C(C(N2N=C(N=C2N1CC(NC3=CC(Cl)=C(C=C3C)C(F)(F)F)=O)C4=CCOCC4)=O)N5C6CN(C(C7=NC=NC(C)=C7O)=O)CC5CC6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Shanghai Jemincare Pharmaceutical CO., LTD. Heterocyclic compound serving as wrn helicase inhibitor, and preparation method for and use of heterocyclic compound. World Intellectual Property Organization, WO2024199109 A1 2024-03-10

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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WRN inhibitor 11

All DNA/RNA Synthesis Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

WRN inhibitor 11 Related Classifications

HY-168583 Related Classifications