Search Result
Results for "
Imidazole
" in MedChemExpress (MCE) Product Catalog:
10
Biochemical Assay Reagents
23
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-D0837
-
Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene
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Endogenous Metabolite
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Others
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Imidazole, a highly polar compound containing planar five-membered rings, has been widely used as a corrosion inhibitor. Derivatives of Imidazole have antimicrobial, anti-inflammatory, and antitumor activities .
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- HY-W045271
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-
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- HY-114481
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IKE
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Ferroptosis
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Cancer
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Imidazole ketone erastin is a potent, selective, and metabolically stable inhibitor of the cystine-glutamate antiporter, system xc - and an activator of ferroptosis. Imidazole ketone erastin has anti-tumor activity .
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- HY-ER010
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Imidazole hydrochloride
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Biochemical Assay Reagents
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Others
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1H-Imidazole hydrochloride can be used as ligand, buffer and catalyst, etc., and also plays an important role in the process of drug synthesis and extraction of natural products. In addition, the compound is widely used in certain industrial fields, such as in the manufacturing process of plastics, coatings, textiles and electronic materials. Although the compound has no direct medical applications, it plays an important role in chemical research and laboratory studies.
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-
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- HY-D0837S
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-
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- HY-B0078
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Imidazole Carboxamide
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Nucleoside Antimetabolite/Analog
Apoptosis
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Cancer
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Dacarbazine is a nonspecific antineoplastic (antineoplastic) alkylating agent. Dacarbazine inhibits T and B lymphocyte responses with IC50 of 50 and 10 μg/mL, respectively. Dacarbazine can be used in the study of metastatic malignant melanoma .
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- HY-B0078B
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Imidazole Carboxamide hydrochloride
|
Antibiotic
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Cancer
|
Dacarbazine hydrochloride is a cell cycle nonspecific antineoplastic alkylating agent. Dacarbazine hydrochloride inhibits T and B lymphoblastic response, with IC50 values of 50 and 10 μg/mL, respectively. Dacarbazine hydrochloride can be used for the research of metastatic malignant melanoma .
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-
- HY-B0078A
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Imidazole Carboxamide citrate
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Apoptosis
Antibiotic
|
Cancer
|
Dacarbazine citrate is a cell cycle nonspecific antineoplastic alkylating agent. Dacarbazine citrate inhibits T and B lymphoblastic response, with IC50 values of 50 and 10 μg/mL, respectively. Dacarbazine Citrate can be used for the research of apoptosis and various cancers such as metastatic malignant melanoma .
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-
-
- HY-113413
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-
-
- HY-B0078S
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-
-
- HY-Y1124S
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-
-
- HY-59137S1
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-
-
- HY-129968
-
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PROTAC Linkers
|
Cancer
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AM-Imidazole-PA-Boc is an alkyl chain-based PROTAC linker can be used in the synthesis of PROTAC IRAK4 degrader-1 (HY-129966) .
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-
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- HY-14113
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-
-
- HY-W010269S
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-
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- HY-W002226
-
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Biochemical Assay Reagents
|
Others
|
4-Bromo-1H-imidazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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-
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- HY-59303
-
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Biochemical Assay Reagents
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Others
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1H-Imidazole-5-carboxaldehyde is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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-
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- HY-W017511
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-
-
- HY-W319671S
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-
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- HY-W007321
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2-FormylImidazole
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Biochemical Assay Reagents
|
Others
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1H-Imidazole-2-carbaldehyde is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
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- HY-W007695
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4-Imidazolecarboxylic acid
|
Biochemical Assay Reagents
|
Others
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1H-Imidazole-4-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
-
- HY-17011
-
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Others
|
Metabolic Disease
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Croconazole is an antifungal agent containing imidazole rings. Croconazole has a unique structural feature of aryl vinyl at the imidazole ring N-1. Croconazole can be used for the identification and quantitative study of major metabolites in rat urine and bile .
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- HY-B0163
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-
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- HY-B0163A
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-
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- HY-W115276
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Bacterial
Fungal
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Infection
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Fenticonazole is an imidazole derivative with antibacterial and antifungal activity. Fenticonazole has the potential for the research of mixed vaginitis .
|
-
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- HY-41461
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5-AminoImidazole-4-carboxamide; AICA
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Endogenous Metabolite
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Others
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5-Amino-3H-imidazole-4-Carboxamide (AICA) is an important precursor for the synthesis of purines in general and of the nucleobases adenine and guanine in particular.
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- HY-W720736
-
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Others
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Cardiovascular Disease
|
Tinazoline, imidazole derivative, is a vasoconstrictor. Tinazoline can as nasal decongestant for the research of common cold .
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-
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- HY-41461A
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5-AminoImidazole-4-carboxamide hydrochloride; AICA hydrochloride
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Biochemical Assay Reagents
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Others
|
5-Amino-3H-imidazole-4-carboxamide hydrochloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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-
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- HY-106048
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5-Hydroxy-1H-Imidazole-4-carboxamide; SM-108
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Nucleoside Antimetabolite/Analog
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Others
|
Bredinin aglycone (5-Hydroxy-1H-imidazole-4-carboxamide) is a purine nucleotide analogue. Bredinin aglycone can be used to examine the efficiency of catalysts for the preparation of purine nucleotide analogues .
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-
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- HY-129060
-
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Fungal
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Infection
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Flutrimazole is an imidazole antifungal with dual anti-inflammatory and antifungal activity. Flutrimazole shows scarce transdermal penetration. Flutrimazole has the advantageous in the research of topical fungal infections with an inflammatory component .
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- HY-14282
-
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Fungal
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Infection
Inflammation/Immunology
|
Lanoconazole is a potent and orally active imidazole antifungal agent, shows a broad spectrum of activity against fungi in vitro and in vivo . Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis. Lanoconazole can be used for the investigation of dermatophytosis and onychomycosis .
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- HY-B1460
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(±)-Sulconazole mononitrate
|
Fungal
Bacterial
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Infection
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Sulconazole mononitrate ((±)-Sulconazole mononitrate), an imidazole derivative, is a broad-spectrum fungicide. Sulconazole mononitrate can be used for the research of dermatomycoses, pityriasis versicolor, and cutaneous candidiasis .
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- HY-129060R
-
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Fungal
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Infection
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Flutrimazole (Standard) is the analytical standard of Flutrimazole. This product is intended for research and analytical applications. Flutrimazole is an imidazole antifungal with dual anti-inflammatory and antifungal activity. Flutrimazole shows scarce transdermal penetration. Flutrimazole has the advantageous in the research of topical fungal infections with an inflammatory component .
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- HY-14282A
-
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Fungal
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Infection
Inflammation/Immunology
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(Z)-Lanoconazole is the Z configuration of Lanoconazole. Lanoconazole is a potent and orally active imidazole antifungal agent, shows a broad spectrum of activity against fungi in vitro and in vivo . Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis. Lanoconazole can be used for the investigation of dermatophytosis and onychomycosis .
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-
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- HY-14282R
-
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Fungal
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Infection
Inflammation/Immunology
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Lanoconazole (Standard) is the analytical standard of Lanoconazole. This product is intended for research and analytical applications. Lanoconazole is a potent and orally active imidazole antifungal agent, shows a broad spectrum of activity against fungi in vitro and in vivo . Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis. Lanoconazole can be used for the investigation of dermatophytosis and onychomycosis .
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- HY-106541
-
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Fungal
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Infection
Cancer
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Neticonazole is an imidazole derivative and a potent and long-acting antifungal agent. Neticonazole has anti-infection and anti-cancer effects .
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- HY-128365
-
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Fungal
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Infection
Cancer
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Neticonazole hydrochloride is an imidazole derivative and a potent and long-acting antifungal agent. Neticonazole hydrochloride has anti-infection and anti-cancer effects .
|
-
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- HY-106542
-
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Fungal
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Infection
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Eberconazole is a dichlorinated imidazole derivative with antifungal activity. Eberconazole is more active than Clotrimazole, Ketoconazole, and Miconazole. Eberconazole has the potential for the research of dermatophytoses with a topical administration .
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- HY-106542A
-
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Fungal
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Infection
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Eberconazole nitrate is a dichlorinated imidazole derivative with antifungal activity. Eberconazole nitrate is more active than Clotrimazole, Ketoconazole, and Miconazole. Eberconazole nitrate has the potential for the research of dermatophytoses with a topical administration .
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- HY-106019C
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R75251 dihydrochloride
|
Cytochrome P450
RAR/RXR
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Metabolic Disease
Inflammation/Immunology
Cancer
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Liarozole (R75251) dihydrochloride is an imidazole derivative and orally active retinoic acid (RA) metabolism-blocking agent (RAMBA). Liarozole dihydrochloride inhibits the cytochrome P450 (CYP26)-dependent 4-hydroxylation of RA (IC50=7 μM), resulting in increased tissue levels of RA. Liarozole dihydrochloride shows antitumoral properties .
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-
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- HY-106019
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R75251
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Cytochrome P450
RAR/RXR
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Metabolic Disease
Inflammation/Immunology
Cancer
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Liarozole (R75251; R85246) is an imidazole derivative and orally active retinoic acid (RA) metabolism-blocking agent (RAMBA). Liarozole inhibits the cytochrome P450 (CYP26)-dependent 4-hydroxylation of retinoic acid (IC50=7 μM), resulting in increased tissue levels of retinoic acid. Liarozole shows antitumoral properties .
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- HY-106541R
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Fungal
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Infection
Cancer
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Neticonazole (Standard) is the analytical standard of Neticonazole. This product is intended for research and analytical applications. Neticonazole is an imidazole derivative and a potent and long-acting antifungal agent. Neticonazole has anti-infection and anti-cancer effects .
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- HY-144034
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GCGR
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Metabolic Disease
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GLP-1R agonist 3 is a potent agonist of GLP-1R. GLP-1R agonist 3 is a thickened imidazole derivative compound. Glucagon-like peptide-1 (GLP-1) is an intestinal hypoglycemic hormone secreted by L-cells in the lower gastrointestinal tract. GLP-1R agonist 3 has the potential for the research of diabetes (extracted from patent WO2021197464A1, compound 1) .
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-
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- HY-144033
-
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GCGR
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Metabolic Disease
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GLP-1R agonist 1 is a potent agonist of GLP-1R. GLP-1R agonist 1 is a thickened imidazole derivative compound. Glucagon-like peptide-1 (GLP-1) is an intestinal hypoglycemic hormone secreted by L-cells in the lower gastrointestinal tract. GLP-1R agonist 1 has the potential for the research of diabetes (extracted from patent WO2021197464A1, compound 4) .
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- HY-134622
-
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CDK
GSK-3
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Neurological Disease
Cancer
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GSK-3/CDK5/CDK2-IN-1, an imidazole derivative, is an inhibitor of cdk5, cdk2, and GSK-3 extracted from patent WO2002010141A1, example 9a. GSK-3/CDK5/CDK2-IN-1 can be used for the research of cancer, and neurodegenerative diseases .
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- HY-147973
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c-Myc
Apoptosis
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Cancer
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IZTZ-1, an imidazole-benzothiazole conjugate, is a c-MYC G4 ligand. IZTZ-1 is able to downregulate the c-MYC expression by stabilizing c-MYC G4. IZTZ-1 induces cell cycle arrest, apoptosis, thereby inhibiting cell proliferation in B16 cells. IZTZ-1 shows antitumor activity, and can be used for melanoma research .
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- HY-B0845
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-
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- HY-U00311
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-
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- HY-N1914S
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L-(+)-Ergothioneine-d3
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Isotope-Labeled Compounds
Endogenous Metabolite
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Others
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Ergothioneine-d3 is the deuterium labeled Ergothioneine. Ergothioneine, an imidazole-2-thione derivative of histidine betaine, is synthesized by certain bacteria and fungi. Ergothioneine is generally considered an antioxidant[1].
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- HY-N1914S1
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L-(+)-Ergothioneine-d9
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Endogenous Metabolite
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Others
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Ergothioneine-d9 is the deuterium labeled Ergothioneine. Ergothioneine, an imidazole-2-thione derivative of histidine betaine, is synthesized by certain bacteria and fungi. Ergothioneine is generally considered an antioxidant[1].
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- HY-B0293A
-
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Fungal
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Infection
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Butoconazole, an imidazole antifungal agent, is active against Candida spp. and effective against vaginal infections due to Candida albicans. Butoconazole is presumed to function as other imidazole derivatives via inhibition of steroid synthesis .
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- HY-B0301
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- HY-W015671
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5-Phenyl-1H-Imidazole
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Biochemical Assay Reagents
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Others
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4-Phenylimidazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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-
- HY-B0293
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RS 35887
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Fungal
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Infection
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Butoconazole nitrate (RS 35887), an imidazole antifungal agent, is active against Candida spp. and effective against vaginal infections due to Candida albicans. Butoconazole nitrate is presumed to function as other imidazole derivatives via inhibition of steroid synthesis .
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- HY-N1914
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L-(+)-Ergothioneine
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Endogenous Metabolite
p38 MAPK
Akt
Keap1-Nrf2
NF-κB
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Others
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Ergothioneine is an imidazole-2-thione derivative with orally active histidine betaine. Ergothioneine is a specific inhibitor of p38-MAPK and Akt, which plays a protective role in cell apoptosis induced by stress. Ergothioneine has antioxidant activity .
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- HY-B0105A
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- HY-160777
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Galeterone 3β-Imidazole
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Androgen Receptor
MNK
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Cancer
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VNPP433-3β is a molecular glue degrader, which degrades androgen receptor (AR) and its splice variants (AR-Vs) and MAP kinase-interacting serine/threonine protein kinase Mnk1/2. VNPP433-3β inhibits proliferation of cancer cell LNCaP, C4-2B and CWR22Rv1 with GI50 of 0.2, 0.3 and 0.31 μM. VNPP433-3β exhibits good pharmacokinetic characters in CD-1 mouse and inhibits tumor growth in the CWR22Rv1 xenograft mouse model .
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- HY-B0454
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- HY-145233
-
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Parasite
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Infection
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PfPKG-IN-1 is a imidazole-based inhibitor of Plasmodium falciparum cGMP-dependent protein kinase (PfPKG).
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- HY-10882
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- HY-B0453
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- HY-B0454A
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R18134 nitrate
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Fungal
Bacterial
Antibiotic
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Infection
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Miconazole nitrate (R18134 nitrate) is an imidazole antifungal agent. Miconazole nitrate also has antibacterial effects .
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- HY-B0105
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- HY-101420
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- HY-144255
-
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ROS Kinase
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Inflammation/Immunology
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Antibacterial agent 70 is a new dihydropyrimidinone imidazole hybrid antibacterial agent, and its < b > MIC < / b > value is 0.5 μg/mL
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- HY-W764737
-
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Isotope-Labeled Compounds
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Cancer
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Methylboronic acid pinacol ester is an orally administered compound that inhibits the activity of peptidases and imidazole derivatives. Methylboronic acid pinacol ester is used as a medicinal preparation for cancer .
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- HY-W020777
-
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Fungal
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Infection
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Triflumizole is one of imidazole fungicides that works by inhibiting ergosterol biosynthesis, and is widely used for the control of powdery mildew and scabs on various fruits and crops .
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- HY-B0301R
-
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Fungal
Antibiotic
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Infection
|
Bifonazole (Standard) is the analytical standard of Bifonazole. This product is intended for research and analytical applications. Bifonazole (Bay H-4502) is an imidazole antifungal agent.
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- HY-B0454S
-
-
- HY-W042985
-
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Biochemical Assay Reagents
|
Others
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1-Benzyl-1H-imidazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
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- HY-B0454S1
-
-
- HY-12195
-
-
- HY-B0105S1
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Ketoconazol-d4; R 41400-d4
|
Fungal
Cytochrome P450
Ras
|
Infection
Cancer
|
Ketoconazole-d4 is the deuterium labeled Ketoconazole. Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.
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- HY-B0105S
-
-
- HY-B0454S2
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R18134-d2
|
Fungal
Bacterial
Antibiotic
|
Infection
|
Miconazole-d2 is the deuterium labeled Miconazole[1]. Miconazole (R18134) is an imidazole antifungal agent. Miconazole also has antibacterial effects[2][3].
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- HY-155712
-
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Fungal
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Infection
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Antifungal agent 70 (compound 13) is a dihydroeugenol-imidazole against multi-resistant Candida auris (MIC: 36.4 μM). Antifungal agent 70 shows antifungal activity .
|
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- HY-10882S
-
-
- HY-10882R
-
|
Fungal
Bacterial
Autophagy
Antibiotic
|
Infection
Cancer
|
Clotrimazole (Standard) is the analytical standard of Clotrimazole. This product is intended for research and analytical applications. Clotrimazole is an imidazole derivative, an antifungal compound and is a CYP (cytochrome P450) inhibitor. Clotrimazole has antibacterial activity.
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- HY-10882S1
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- HY-50914
-
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CDK
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Cancer
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AZD5597 is an inhibitor of CDK with an IC50 of 2 nM. AZD5597 has potent anti-proliferative effects against a range of cancer cell lines .
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- HY-155709
-
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Fungal
|
Infection
|
Antifungal agent 67 (compound 9) is an imidazole antifungal agent that is effective against Candida. Antifungal agent 67 has a CC50 value of 33.6 μM on healthy neonatal rat cardiomyoblasts .
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- HY-155711
-
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Fungal
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Infection
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Antifungal agent 69 (compound 13) is a eugenol-imidazole against Candida albicans (MIC: 4.6 μM) with no relevant cytotoxicity. Antifungal agent 69 alters the fungal ergosterol biosynthesis and shows antifungal activity .
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- HY-B0454AR
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R18134 nitrate (Standard)
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Fungal
Bacterial
Antibiotic
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Infection
|
Miconazole (nitrate) (Standard) is the analytical standard of Miconazole (nitrate). This product is intended for research and analytical applications. Miconazole nitrate (R18134 nitrate) is an imidazole antifungal agent. Miconazole nitrate also has antibacterial effects .
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- HY-14283
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NND 502
|
Fungal
Antibiotic
|
Infection
|
Luliconazole (NND 502) is a topical antifungal imidazole antibiotic with broad-spectrum and potent antifungal activity. Luliconazole can be used for the research of skin infection, including dermatophytosis, tinea corporis, tinea pedis et al .
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- HY-101653
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-
- HY-B0319
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UK-20349
|
Fungal
Antibiotic
|
Infection
|
Tioconazole (UK-20349) is an antifungal imidazole derivative with broad spectrum activity. Tioconazole has inhibitory active aginst several dermatophytes and several yeasts with MIC50s <3.12 mg/L and <9 mg/L, respectively .
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- HY-Y1055
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Guanine
3 Publications Verification
|
DNA/RNA Synthesis
Endogenous Metabolite
|
Cancer
|
Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool .
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- HY-150691
-
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SARS-CoV
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Cancer
|
SARS 3CLpro-IN-1 (Compound 3b) is a SARS 3CL protease inhibitor with an IC50 value of 95 μM, as a specific stereo isomer of the octahydroisochromene scaffold, directs the P1 site imidazole .
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- HY-107562
-
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Histamine Receptor
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Neurological Disease
|
JNJ-10181457 is a neutral, potent, brain-penetrant and selective non-imidazole H3 antagonist which increases NE and ACh concentrations in rat frontal cortex. JNJ-10181457 can be used for neurological research .
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- HY-B0359
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REC 15-1476
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Fungal
Antibiotic
|
Infection
|
Fenticonazole Nitrate is an antifungal imidazole ring derivative. Fenticonazole Nitrate operates via hindering ergosterol integration, and sequentially destructing the cytoplasmatic outer membrane. Fenticonazole Nitrate is effective against Gram-positive bacteria, mycoses, and vaginal candidiasis .
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- HY-B1460B
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(±)-Sulconazole
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Fungal
|
Cancer
|
Sulconazole is a potent antifungal agent in the imidazole class. Sulconazole blocks the NF-κB/IL-8 signaling pathway and CSC (Cancer stem cells) formation. Sulconazole inhibits tumor growth, and can be used for breast cancer research .
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- HY-B0454AS
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R18134-d5 (nitrate) (2,4-Dichlorobenzyloxy-d5)
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Fungal
Bacterial
Antibiotic
|
Infection
|
Miconazole-d5 (nitrate) (2,4-Dichlorobenzyloxy-d5) is the deuterium labeled Miconazole nitrate. Miconazole nitrate (R18134 nitrate) is an imidazole antifungal agent. Miconazole nitrate also has antibacterial effects[2].
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- HY-Y1055S
-
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DNA/RNA Synthesis
Endogenous Metabolite
|
Cancer
|
Guanine- 13C is the 13C labeled Guanine[1]. Guanine (2-Aminohypoxanthine) is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds.
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- HY-162271
-
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Topoisomerase
Fungal
|
Infection
|
Antibacterial agent 187 (IKE7) is a derivative containing imidazole and triazolacridone structures that target yeast topoisomerase II. Antibacterial agent 187 has antifungal activity and MIC value of resistance to fluconazole (HY-B0101) is 32-64 μg/mL .
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- HY-N9542
-
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Others
|
Others
|
Dimethylurea/citric acid is a highly efficient deep eutectic solvent (DES). Dimethylurea/citric acid can be used as a catalyst and a green reaction medium for the synthesis of bis(indolyl)methanes, quinolines and aryl-4, 5-diphenyl-1H-imidazoles.
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- HY-Y1055S3
-
-
- HY-107562A
-
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Histamine Receptor
|
Neurological Disease
|
JNJ-10181457 is a selective non-imidazole histamine H3 receptor antagonist that normalizes acetylcholine neurotransmission . JNJ-10181457 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-Y1055S4
-
-
- HY-161271
-
|
Mixed Lineage Kinase
|
Neurological Disease
Cancer
|
MLK-IN-2 (Compound 9a) is a Mixed Lineage Kinase 3 (MLK3) inhibitor containing 3H-imidazole [4,5-b] pyridine structure. IC50 value is 6 nM. MLK-IN-2 can be used to study cancer and neurodegenerative diseases .
|
-
- HY-119427
-
|
Others
|
Cancer
|
Anti-melanoma agent 3 (compound 5cb) is a 2-aryl-4-benzoyl-imidazole (ABI) derivative and an inhibitor of melanoma xenogeneic tumors. Anti-melanoma agent 3 exerts anticancer activity by interacting with the colchicine binding site to inhibit tubulin polymerization .
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- HY-Y1055S1
-
|
DNA/RNA Synthesis
Endogenous Metabolite
|
Cancer
|
Guanine- 13C, 15N2 is the 13C and 15N labeled Guanine[1]. Guanine (2-Aminohypoxanthine) is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds.
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-
- HY-14283R
-
|
Fungal
Antibiotic
|
Infection
|
Luliconazole (Standard) is the analytical standard of Luliconazole. This product is intended for research and analytical applications. Luliconazole (NND 502) is a topical antifungal imidazole antibiotic with broad-spectrum and potent antifungal activity. Luliconazole can be used for the research of skin infection, including dermatophytosis, tinea corporis, tinea pedis et al .
|
-
- HY-144650
-
|
Apoptosis
HSP
|
Cancer
|
Hsp90-Cdc37-IN-3 (Compound 9) is a novel celastrol−imidazole derivative with anticancer activity. Hsp90-Cdc37-IN-3 inhibits Hsp90−Cdc37 by covalent-binding, and induces apoptosis .
|
-
- HY-155710
-
|
Fungal
|
Infection
|
Antifungal agent 68 (compound 10) is an antifungal agent against Candida and Cryptococcus gattii. Antifungal agent 68 inhibits fungal ergosterol biosynthesis, possibly by targeting lanosterol 14α-demethylase (CYP51). There is an interaction between the imidazole ring of antifungal agent 68 and the heme group of CYP51 .
|
-
- HY-B0319R
-
|
Fungal
Antibiotic
|
Infection
|
Tioconazole (Standard) is the analytical standard of Tioconazole. This product is intended for research and analytical applications. Tioconazole (UK-20349) is an antifungal imidazole derivative with broad spectrum activity. Tioconazole has inhibitory active aginst several dermatophytes and several yeasts with MIC50s <3.12 mg/L and <9 mg/L, respectively .
|
-
- HY-Y1055S2
-
|
Isotope-Labeled Compounds
DNA/RNA Synthesis
Endogenous Metabolite
|
Cancer
|
Guanine- 13C5, 15N5 is 13C and 15N-labeled Guanine (HY-Y1055). Guanine (2-Aminohypoxanthine) is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds.
|
-
- HY-D0846
-
|
Biochemical Assay Reagents
|
Neurological Disease
|
Diethyl pyrocarbonate is a potent, orally active, non-specific chemical inhibitor of RNase. Diethyl pyrocarbonate has been useful in vitro as an agent relatively specific for binding to imidazole of histidine. Diethyl pyrocarbonate inhibits central chemosensitivity in rabbits. Diethyl pyrocarbonate can modify Ser, Thr, His and Tyr residues. Diethyl pyrocarbonate can be used for modeling .
|
-
- HY-114883
-
L-Homocarnosine; γ-Aminobutyryl-L-histidine
|
GABA Receptor
Endogenous Metabolite
|
Neurological Disease
Inflammation/Immunology
|
Homocarnosine is a dipeptide of γ-aminobutyric acid (GABA) and histidine unique to brain. Homocarnosine is an inhibitory neuromodulator synthesized in the neuron from GABA and exhibiting anticonvulsant effects .Homocarnosine has antioxidant and anti-inflammatory actions, prevention of DNA damage, and inhibition of advanced glycation end-product formation .
|
-
- HY-17470
-
NSC 289637; HE 69
|
HCV
SARS-CoV
Antibiotic
Parasite
|
Inflammation/Immunology
|
Mizoribine (NSC 289637), an imidazole nucleoside, inhibits HCV RNA replication with IC50 of approximately 100 μM for anti-HCV activity. Immunosuppressant . Mizoribine, an IMPDH inhibitor, inhibits replication of SARS-CoV with IC50s of 3.5 μg/mL and 16 μg/mL for SARS-CoV Frankfurt-1 and SARS-CoV HKU39849, respectively .
|
-
- HY-115905
-
|
Parasite
|
Infection
|
Antimalarial agent 9 (Compound 11) is a potent antimalarial agent. Antimalarial agent 9 is a quinoline-imidazole derivative compound. Antimalarial agent 9 exhibits significant antimalarial efficacy in-vitro against both CQ-sensitive (IC50-0.14 μM) and MDR strain (IC50-0.41 μM) with minimal cytotoxicity and high selectivity .
|
-
- HY-161153
-
|
Apoptosis
|
Cancer
|
Microtubule inhibitor 9 (Compound O-7) is a 2-Aryl-1H-benzo [d] imidazole derivative with in vitro anticancer activity. Microtubule inhibitor 9 can induce cell cycle arrest at the G2/M phase and early apoptosis. Microtubule inhibitor 9 inhibits cancer cell migration by inhibiting wound healing and colony formation .
|
-
- HY-B1118
-
RP-14539; PM-185184
|
Parasite
Antibiotic
Bacterial
|
Infection
|
Secnidazole (RP-14539) is an orally active azole antibiotic and a imidazole mitigator of Serratia marcescens virulence. Secnidazole, as an analog of acylhomoserine lactones, effectively inhibits QS resulting in the attenuation of Pseudomonas aeruginosa pathogenesis. Secnidazole has antimicrobial activity against many anaerobic Gram-negative and Gram-positive bacterial species in vitro. Secnidazole can be used for the research of various diseases, such as amoebiasis and giardiasis, and bacterial vaginitis .
|
-
- HY-117970
-
|
MMP
|
Cardiovascular Disease
|
MMPI-1154 is a promising novel cardio-cytoprotective imidazole-carboxylic acid (ICA) MMP-2 inhibitor(IC50=6.6 μM) and can be used for the study of acute myocardial infarction. MMPI-1154 also inhibits the activity of MMP-13, MMP-1 and MMP-9 with IC50s of 1.8 μM,10 μM, and 13 μM, respectively .
|
-
- HY-B1118A
-
RP-14539 hemihydrate; PM-185184 hemihydrate
|
Antibiotic
Bacterial
Parasite
|
Infection
|
Secnidazole (RP-14539) hemihydrate is an orally active azole antibiotic and a imidazole mitigator of Serratia marcescens virulence. Secnidazole hemihydrate, as an analog of acylhomoserine lactones, effectively inhibits QS resulting in the attenuation of Pseudomonas aeruginosa pathogenesis. Secnidazole hemihydrate has antimicrobial activity against many anaerobic Gram-negative and Gram-positive bacterial species in vitro. Secnidazole hemihydrate can be used for the research of various diseases, such as amoebiasis and giardiasis, and bacterial vaginitis .
|
-
- HY-17470R
-
|
HCV
SARS-CoV
Antibiotic
Parasite
|
Inflammation/Immunology
|
Mizoribine (Standard) is the analytical standard of Mizoribine. This product is intended for research and analytical applications. Mizoribine (NSC 289637), an imidazole nucleoside, inhibits HCV RNA replication with IC50 of approximately 100 μM for anti-HCV activity. Immunosuppressant . Mizoribine, an IMPDH inhibitor, inhibits replication of SARS-CoV with IC50s of 3.5 μg/mL and 16 μg/mL for SARS-CoV Frankfurt-1 and SARS-CoV HKU39849, respectively .
|
-
- HY-B1118S2
-
RP-14539-d4; PM-185184-d4
|
Bacterial
Parasite
Antibiotic
|
Infection
|
Secnidazole-d4 is the deuterium labeled Secnidazole[1]. Secnidazole (RP-14539) is an orally active azole antibiotic and a imidazole mitigator of Serratia marcescens virulence. Secnidazole, as an analog of acylhomoserine lactones, effectively inhibits QS resulting in the attenuation of Pseudomonas aeruginosa pathogenesis. Secnidazole has antimicrobial activity against many anaerobic Gram-negative and Gram-positive bacterial species in vitro. Secnidazole can be used for the research of various diseases, such as amoebiasis and giardiasis, and bacterial vaginitis[1][2][3].
|
-
- HY-B1118R
-
|
Parasite
Antibiotic
Bacterial
|
Infection
|
Secnidazole (Standard) is the analytical standard of Secnidazole. This product is intended for research and analytical applications. Secnidazole (RP-14539) is an orally active azole antibiotic and a imidazole mitigator of Serratia marcescens virulence. Secnidazole, as an analog of acylhomoserine lactones, effectively inhibits QS resulting in the attenuation of Pseudomonas aeruginosa pathogenesis. Secnidazole has antimicrobial activity against many anaerobic Gram-negative and Gram-positive bacterial species in vitro. Secnidazole can be used for the research of various diseases, such as amoebiasis and giardiasis, and bacterial vaginitis .
|
-
- HY-151929
-
|
JNK
|
Neurological Disease
|
JNK3 inhibitor-4 is a potent inhibitor of JNK3 (IC50=1.0 nM) based on 2-aryl-1-pyrimidinyl-1H-imidazole-5-yl acetonitrile. JNK3 inhibitor-4 shows excellent selectivity over other protein kinases including isoforms JNK1 (IC50=143.9 nM) and JNK2 (IC50=298.2 nM) . JNK3 inhibitor-4 has neuroprotective effect and predicated blood-brain barrier permeability .
|
-
- HY-66019
-
FITC
Maximum Cited Publications
39 Publications Verification
Fluorescein 5-isothiocyanate
|
Fluorescent Dye
|
Others
|
FITC (Fluorescein Isothiocyanate), is one of the green fluorescein derivatives widely used in biology. FITC has the characteristics of high absorptivity, excellent fluorescence quantum yield and good water solubility. The isothiocyanate group of FITC can be combined with amino, sulfhydryl, imidazole, tyrosyl, carbonyl and other groups on the protein, so as to achieve protein labeling including antibodies and lectins. In addition to its use as a protein marker, FITC can also be used as a fluorescent protein tracer to rapidly identify pathogens by labeling antibodies, or for microsequencing of proteins and peptides (HPLC). The maximum excitation wavelength of FITC is 494 nm. Once excited, it fluoresces yellow-green at a maximum emission wavelength of 520 nm.
|
-
Cat. No. |
Product Name |
Type |
-
- HY-66019
-
Fluorescein 5-isothiocyanate
|
Fluorescent Dyes/Probes
|
FITC (Fluorescein Isothiocyanate), is one of the green fluorescein derivatives widely used in biology. FITC has the characteristics of high absorptivity, excellent fluorescence quantum yield and good water solubility. The isothiocyanate group of FITC can be combined with amino, sulfhydryl, imidazole, tyrosyl, carbonyl and other groups on the protein, so as to achieve protein labeling including antibodies and lectins. In addition to its use as a protein marker, FITC can also be used as a fluorescent protein tracer to rapidly identify pathogens by labeling antibodies, or for microsequencing of proteins and peptides (HPLC). The maximum excitation wavelength of FITC is 494 nm. Once excited, it fluoresces yellow-green at a maximum emission wavelength of 520 nm.
|
Cat. No. |
Product Name |
Type |
-
- HY-D0837
-
Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene
|
Biochemical Assay Reagents
|
Imidazole, a highly polar compound containing planar five-membered rings, has been widely used as a corrosion inhibitor. Derivatives of Imidazole have antimicrobial, anti-inflammatory, and antitumor activities .
|
-
- HY-ER010
-
Imidazole hydrochloride
|
Co-solvents
|
1H-Imidazole hydrochloride can be used as ligand, buffer and catalyst, etc., and also plays an important role in the process of drug synthesis and extraction of natural products. In addition, the compound is widely used in certain industrial fields, such as in the manufacturing process of plastics, coatings, textiles and electronic materials. Although the compound has no direct medical applications, it plays an important role in chemical research and laboratory studies.
|
-
- HY-W002226
-
|
Biochemical Assay Reagents
|
4-Bromo-1H-imidazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-59303
-
|
Biochemical Assay Reagents
|
1H-Imidazole-5-carboxaldehyde is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W007321
-
2-FormylImidazole
|
Biochemical Assay Reagents
|
1H-Imidazole-2-carbaldehyde is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W007695
-
4-Imidazolecarboxylic acid
|
Biochemical Assay Reagents
|
1H-Imidazole-4-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-41461A
-
5-AminoImidazole-4-carboxamide hydrochloride; AICA hydrochloride
|
Biochemical Assay Reagents
|
5-Amino-3H-imidazole-4-carboxamide hydrochloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W015671
-
5-Phenyl-1H-Imidazole
|
Biochemical Assay Reagents
|
4-Phenylimidazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W042985
-
|
Biochemical Assay Reagents
|
1-Benzyl-1H-imidazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-D0846
-
|
Biochemical Assay Reagents
|
Diethyl pyrocarbonate is a potent, orally active, non-specific chemical inhibitor of RNase. Diethyl pyrocarbonate has been useful in vitro as an agent relatively specific for binding to imidazole of histidine. Diethyl pyrocarbonate inhibits central chemosensitivity in rabbits. Diethyl pyrocarbonate can modify Ser, Thr, His and Tyr residues. Diethyl pyrocarbonate can be used for modeling .
|
Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
Cat. No. |
Product Name |
Chemical Structure |
-
- HY-Y1124S
-
|
4-Methyl-imidazole-d3 is the deuterium labeled 4-Methyl-imidazole[1].
|
-
-
- HY-D0837S
-
|
Imidazole-d4 is the deuterium labeled Imidazole[1].
|
-
-
- HY-B0078S
-
|
Dacarbazine-d6 is the deuterium labeled Dacarbazine. Dacarbazine(DTIC-Dome; DTIC) is an antineoplastic agent. It has significant activity against melanomas.
|
-
-
- HY-59137S1
-
|
1-Methyl-imidazole-d3 is the deuterium labeled 1-Methylimidazole[1].
|
-
-
- HY-W010269S
-
|
5-Methoxy-1H-benzo[d]imidazole-d3 is the deuterium labeled 5-Methoxy-1H-benzo[d]imidazole[1].
|
-
-
- HY-W319671S
-
|
2-Methoxy-4,5-dihydro-1H-imidazole-d4 is the deuterium labeled 2-Methoxy-4,5-dihydro-1H-imidazole[1].
|
-
-
- HY-N1914S
-
|
Ergothioneine-d3 is the deuterium labeled Ergothioneine. Ergothioneine, an imidazole-2-thione derivative of histidine betaine, is synthesized by certain bacteria and fungi. Ergothioneine is generally considered an antioxidant[1].
|
-
-
- HY-N1914S1
-
|
Ergothioneine-d9 is the deuterium labeled Ergothioneine. Ergothioneine, an imidazole-2-thione derivative of histidine betaine, is synthesized by certain bacteria and fungi. Ergothioneine is generally considered an antioxidant[1].
|
-
-
- HY-W764737
-
|
Methylboronic acid pinacol ester is an orally administered compound that inhibits the activity of peptidases and imidazole derivatives. Methylboronic acid pinacol ester is used as a medicinal preparation for cancer .
|
-
-
- HY-B0454S
-
|
Miconazole-d5 is the deuterium labeled Miconazole. Miconazole (R18134) is an imidazole antifungal agent. Miconazole also has antibacterial effects[2].
|
-
-
- HY-B0454S1
-
|
Miconazole-d5 (nitrate) is the deuterium labeled Miconazole. Miconazole (R18134) is an imidazole antifungal agent. Miconazole also has antibacterial effects[2].
|
-
-
- HY-B0105S1
-
|
Ketoconazole-d4 is the deuterium labeled Ketoconazole. Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.
|
-
-
- HY-B0105S
-
|
Ketoconazole-d8 is the deuterium labeled Ketoconazole. Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.
|
-
-
- HY-B0454S2
-
|
Miconazole-d2 is the deuterium labeled Miconazole[1]. Miconazole (R18134) is an imidazole antifungal agent. Miconazole also has antibacterial effects[2][3].
|
-
-
- HY-10882S
-
|
Clotrimazole-d5 is the deuterium labeled Clotrimazole. Clotrimazole is an imidazole derivative, an antifungal compound and is a CYP (cytochrome P450) inhibitor. Clotrimazole has antibacterial activity[1][2].
|
-
-
- HY-10882S1
-
|
Clotrimazole-d10 is deuterated labeled Clotrimazole (HY-10882). Clotrimazole is an imidazole derivative, an antifungal compound and is a CYP (cytochrome P450) inhibitor. Clotrimazole has antibacterial activity.
|
-
-
- HY-B0454AS
-
|
Miconazole-d5 (nitrate) (2,4-Dichlorobenzyloxy-d5) is the deuterium labeled Miconazole nitrate. Miconazole nitrate (R18134 nitrate) is an imidazole antifungal agent. Miconazole nitrate also has antibacterial effects[2].
|
-
-
- HY-Y1055S
-
|
Guanine- 13C is the 13C labeled Guanine[1]. Guanine (2-Aminohypoxanthine) is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds.
|
-
-
- HY-Y1055S3
-
|
Guanine- 15N5 is 15N labeled Guanine (HY-Y1055). Guanine (2-Aminohypoxanthine) is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds.
|
-
-
- HY-Y1055S4
-
|
Guanine- 13C5 is 13C-labeled Guanine (HY-Y1055). Guanine (2-Aminohypoxanthine) is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds.
|
-
-
- HY-Y1055S1
-
|
Guanine- 13C, 15N2 is the 13C and 15N labeled Guanine[1]. Guanine (2-Aminohypoxanthine) is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds.
|
-
-
- HY-Y1055S2
-
|
Guanine- 13C5, 15N5 is 13C and 15N-labeled Guanine (HY-Y1055). Guanine (2-Aminohypoxanthine) is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds.
|
-
-
- HY-B1118S2
-
|
Secnidazole-d4 is the deuterium labeled Secnidazole[1]. Secnidazole (RP-14539) is an orally active azole antibiotic and a imidazole mitigator of Serratia marcescens virulence. Secnidazole, as an analog of acylhomoserine lactones, effectively inhibits QS resulting in the attenuation of Pseudomonas aeruginosa pathogenesis. Secnidazole has antimicrobial activity against many anaerobic Gram-negative and Gram-positive bacterial species in vitro. Secnidazole can be used for the research of various diseases, such as amoebiasis and giardiasis, and bacterial vaginitis[1][2][3].
|
-
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