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Cat. No.: HY-107562

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JNJ 10181457 dihydrochloride

Name: JNJ 10181457 dihydrochloride
Brand: MedChemExpress
SKU: HY-107562
Price: 70.00 USD
Availability: InStock
Rating: 5 (1 reviews)

JNJ-10181457 is a neutral, potent, brain-penetrant and selective non-imidazole H₃ antagonist which increases NE and ACh concentrations in rat frontal cortex. JNJ-10181457 can be used for neurological research.

For research use only. We do not sell to patients.

CAS No.: 544707-20-2
Formula: C₂₀H₃₀Cl₂N₂O
Molecular Weight:385.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

JNJ 10181457 dihydrochloride Chemical Structure

CAS No.: 544707-20-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

HY-117046A

AVN-101 hydrochloride

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

H₃ Receptor

All Histamine Receptor Isoforms :

In Vivo

JNJ-10181457 (10 mg/kg, i.p., 60 min) reverses Imetit (HY-101173, 3 mg/kg, s.c.)-induced water licking in rats and Scopolamine (HY-N0296, 0.06 mg/kg, i.p.)-induced increasing of incorrect responding in DNMTP task^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 544707-20-2
Molecular Weight 385.37
Formula C₂₀H₃₀Cl₂N₂O
SMILES

N1(CCCCC1)CCC#CC2=CC=CC(CN3CCOCC3)=C2.Cl.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Galici R, et al. JNJ-10181457, a selective non-imidazole histamine H(3) receptor antagonist, normalizes acetylcholine neurotransmission and has efficacy in translational rat models of cognition. Neuropharmacology. 2009 Jun;56(8):1131-7. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
References

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JNJ 10181457 dihydrochloride

AVN-101 hydrochloride

All Histamine Receptor Isoforms