1. Anti-infection
  2. Fungal
  3. Neticonazole hydrochloride

Neticonazole hydrochloride 

Cat. No.: HY-128365 Purity: 98.58%
Handling Instructions

Neticonazole hydrochloride is an imidazole derivative and a potent and long-acting antifungal agent. Neticonazole hydrochloride is also an orally active exosome biogenesis and secretion inhibitor. Neticonazole hydrochloride has anti-infection and anti-cancer effects.

For research use only. We do not sell to patients.

Neticonazole hydrochloride Chemical Structure

Neticonazole hydrochloride Chemical Structure

CAS No. : 130773-02-3

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10 mM * 1 mL in DMSO USD 83 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Neticonazole hydrochloride is an imidazole derivative and a potent and long-acting antifungal agent. Neticonazole hydrochloride is also an orally active exosome biogenesis and secretion inhibitor. Neticonazole hydrochloride has anti-infection and anti-cancer effects[1][2][3].

IC50 & Target

Fungal [1]
Exosome secretion[2]

In Vitro

Neticonazole (10 µM; 48 hours; C4-2B cells) treatment decreases the levels of both Alix and Rab27a, and significantly decreases nSMase2 levels. Neticonazole causes a significant inhibition in p-ERK levels[2].
Neticonazole (0-10 µM) exhibits a potent and dose-dependent inhibition of exosome release from C4-2B cells[2]. Imidazole, antifungal, long-acting, exosome, secretion, anti-cancer, colorectal, p-ERK, anti-infection, nSMase2

Western Blot Analysis[2]

Cell Line: C4-2B cells
Concentration: 10 µM
Incubation Time: 48 hours
Result: Decreased the levels of both Alix and Rab27a, and significantly decreased nSMase2 levels.
In Vivo

Neticonazole (1-100 ng/kg; oral gavage; daily; for 15 days; male C57BL/6 mice) treatment significantly improves the survival of intestinal dysbacteriosis (IDB) mice with colorectal cancer (CRC) xenograft tumors, likely through increasing apoptosis of CRC xenograft tumor cells[3].

Animal Model: Male C57BL/6 mice (8 weeks old) given ampicillin, neomycin, metronidazole and vancomycin, and injected with SW480 cells[3]
Dosage: 1 ng/kg, 10 ng/kg and 100 ng/kg
Administration: Oral gavage; daily; for 15 days
Result: Significantly improved the survival of IDB mice with CRC xenograft tumors.
Molecular Weight

338.90

Formula

C₁₇H₂₃ClN₂OS

CAS No.

130773-02-3

SMILES

CCCCCOC1=CC=CC=C1/C(N2C=CN=C2)=C\SC.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (737.68 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9507 mL 14.7536 mL 29.5072 mL
5 mM 0.5901 mL 2.9507 mL 5.9014 mL
10 mM 0.2951 mL 1.4754 mL 2.9507 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 6.25 mg/mL (18.44 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 6.25 mg/mL (18.44 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 6.25 mg/mL (18.44 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

NeticonazoleFungalImidazoleantifungallong-actingexosomesecretionanti-cancercolorectalp-ERKanti-infectionnSMase2hydrochlorideInhibitorinhibitorinhibit

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Product name:
Neticonazole hydrochloride
Cat. No.:
HY-128365
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