1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
  2. Histamine Receptor
  3. VUF10460

VUF10460 

Cat. No.: HY-101420 Purity: ≥98.0%
Handling Instructions

VUF10460 is a non-imidazole histamine H4 receptor agonist; binds to rat H4 receptor with a pKi of 7.46.

For research use only. We do not sell to patients.

VUF10460 Chemical Structure

VUF10460 Chemical Structure

CAS No. : 1028327-66-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 100 In-stock
Estimated Time of Arrival: December 31
25 mg USD 200 In-stock
Estimated Time of Arrival: December 31
50 mg USD 350 In-stock
Estimated Time of Arrival: December 31
100 mg USD 550 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

VUF10460 is a non-imidazole histamine H4 receptor agonist; binds to rat H4 receptor with a pKi of 7.46.

IC50 & Target

pKi: 7.46 (H4)[1]

In Vitro

UF10460 binds to rat H3 and H4 receptor with pKi values of 5.75, and 7.46, respectively. VUF10460 displays approximately a 50-fold selectivity for the rat H4 receptor over the H3 receptor[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

HCl-induced rat gastric lesions is significantly enhanced by the H4 receptor agonists VUF10460. This effect is not modified by H4 receptor antagonist JNJ7777120[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

269.34

Formula

C₁₅H₁₉N₅

CAS No.

1028327-66-3

SMILES

NC1=NC(C2=CC=CC=C2)=CC(N3CCN(C)CC3)=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 36 mg/mL (133.66 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7128 mL 18.5639 mL 37.1278 mL
5 mM 0.7426 mL 3.7128 mL 7.4256 mL
10 mM 0.3713 mL 1.8564 mL 3.7128 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1]

Rats: VUF10460 is dissolved in 100% DMSO. Gastric lesions are induced in 24 h fasted rats by a single intragastric administration of 0.6 N HCl (5mL/kg volume). Drugs under study are administered subcutaneously 30 min before HCl. Rats are randomly divided to receive single doses (10 and/or 30 mg/kg) of immethridine, methimepip, immepip, VUF8430, VUF10460 or the vehicle, in a 1 mL/kg volume[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

VUF10460VUF 10460VUF-10460Histamine ReceptorInhibitorinhibitorinhibit

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Product Name:
VUF10460
Cat. No.:
HY-101420
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