1. Metabolic Enzyme/Protease
  2. MMP
  3. MMPI-1154

MMPI-1154 

Cat. No.: HY-117970 Purity: 99.87%
Handling Instructions

MMPI-1154 is a promising novel cardio-cytoprotective imidazole-carboxylic acid (ICA) MMP-2 inhibitor(IC50=6.6 μM) and can be used for the study of acute myocardial infarction. MMPI-1154 also inhibits the activity of MMP-13, MMP-1 and MMP-9 with IC50s of 1.8 μM,10 μM, and 13 μM, respectively.

For research use only. We do not sell to patients.

MMPI-1154 Chemical Structure

MMPI-1154 Chemical Structure

CAS No. : 1382722-47-5

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 330 In-stock
Estimated Time of Arrival: December 31
5 mg USD 300 In-stock
Estimated Time of Arrival: December 31
10 mg USD 500 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

MMPI-1154 is a promising novel cardio-cytoprotective imidazole-carboxylic acid (ICA) MMP-2 inhibitor(IC50=6.6 μM) and can be used for the study of acute myocardial infarction. MMPI-1154 also inhibits the activity of MMP-13, MMP-1 and MMP-9 with IC50s of 1.8 μM,10 μM, and 13 μM, respectively[1].

IC50 & Target[1]

MMP-2

6.6 μM (IC50)

MMP-13

1.8 μM (IC50)

MMP-1

10 μM (IC50)

MMP-9

13 μM (IC50)

In Vitro

MMPI-1154 (1-100 μM) inhibits MMP-2 enzyme isolated from rat heart in vitro, and 100% inhibition appears at the concentraction 100 μM[1].
MMPI-1154 (1 μM) shows significant cardio-cytoprotecion, significantly decreases infarct size in an ex vivo model for acute myocardial infarction[1].

Molecular Weight

445.49

Formula

C₂₆H₂₄FN₃O₃

CAS No.

1382722-47-5

SMILES

O=C(C1=CN=C(CN(CC2=CC=C(F)C=C2)CC3=CC=C(OCC4=CC=CC=C4)C=C3)N1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (187.05 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2447 mL 11.2236 mL 22.4472 mL
5 mM 0.4489 mL 2.2447 mL 4.4894 mL
10 mM 0.2245 mL 1.1224 mL 2.2447 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

MMPI-1154MMPI1154MMPI 1154MMPMatrix metalloproteinasesacutemyocardialinfarctionischemiareperfusion injuryCoronaryheart diseaseCHDcardioprotectionAMLInhibitorinhibitorinhibit

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MMPI-1154
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