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Cat. No.: HY-N19313

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Agelastatin D

Agelastatin D is a pyrrole-imidazole alkaloid and cytotoxic agent found in the Western Australian sponge Cymbastela sp.. Agelastatin D induces cytotoxic activity against cancer cells. Agelastatin D can be used for the research of chronic lymphocytic leukemia.

For research use only. We do not sell to patients.

CAS No.: 201338-45-6
Formula: C₁₁H₁₁BrN₄O₃
Molecular Weight:327.13

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Agelastatin D Chemical Structure

CAS No.: 201338-45-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	EC₅₀	13.7 μM Compound: 2b	Antitumor activity against human HeLa cells assessed as cell viability by MTT assay Antitumor activity against human HeLa cells assessed as cell viability by MTT assay	[PMID: 24673739]

In Vitro

Agelastatin D (compound 2b) exhibits cytotoxic activity against CLL1, CLL2, JVM-2, and HeLa cell lines with EC₅₀ values at 48 h of 91.1 μM, 29.0 μM, 13.2 μM, and 13.7 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

primary chronic lymphocytic leukemia (CLL) patient cell lines (CLL1, CLL2), immortalized leukemic JVM-2 cell line, HeLa cell line
Concentration:

dose-response format (CLL1, CLL2, JVM-2); dose-response format (HeLa)
Incubation Time:

48 h (CLL1, CLL2, JVM-2); overnight (HeLa)
Result:

Exhibited cytotoxic activity with EC₅₀ values of 91.1 μM (CLL1), 29.0 μM (CLL2), 13.2 μM (JVM-2), and 13.7 μM (HeLa).

Chemical Information

CAS No. 201338-45-6
Molecular Weight 327.13
Formula C₁₁H₁₁BrN₄O₃
SMILES

BrC(N1[C@@]2([H])[C@](N3)([H])[C@@]4([H])[C@@](C2)(NC(N4)=O)O)=CC=C1C3=O
Structure Classification
- Others
Initial Source
- Animals
Cymbastela sp.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Stout EP, et al. Potent fluorinated agelastatin analogues for chronic lymphocytic leukemia: design, synthesis, and pharmacokinetic studies. J Med Chem. 2014;57(12):5085-5093. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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