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  4. Agelastatin D

Agelastatin D is a pyrrole-imidazole alkaloid and cytotoxic agent found in the Western Australian sponge Cymbastela sp.. Agelastatin D induces cytotoxic activity against cancer cells. Agelastatin D can be used for the research of chronic lymphocytic leukemia.

For research use only. We do not sell to patients.

Agelastatin D

Agelastatin D Chemical Structure

CAS No. : 201338-45-6

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Agelastatin D Related Antibodies

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Description

Agelastatin D is a pyrrole-imidazole alkaloid and cytotoxic agent found in the Western Australian sponge Cymbastela sp.. Agelastatin D induces cytotoxic activity against cancer cells. Agelastatin D can be used for the research of chronic lymphocytic leukemia[1].

In Vitro

Agelastatin D (compound 2b) exhibits cytotoxic activity against CLL1, CLL2, JVM-2, and HeLa cell lines with EC50 values at 48 h of 91.1 μM, 29.0 μM, 13.2 μM, and 13.7 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Agelastatin D Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: primary chronic lymphocytic leukemia (CLL) patient cell lines (CLL1, CLL2), immortalized leukemic JVM-2 cell line, HeLa cell line
Concentration: dose-response format (CLL1, CLL2, JVM-2); dose-response format (HeLa)
Incubation Time: 48 h (CLL1, CLL2, JVM-2); overnight (HeLa)
Result: Exhibited cytotoxic activity with EC50 values of 91.1 μM (CLL1), 29.0 μM (CLL2), 13.2 μM (JVM-2), and 13.7 μM (HeLa).
Molecular Weight

327.13

Formula

C11H11BrN4O3
CAS No.
SMILES

BrC(N1[C@@]2([H])[C@](N3)([H])[C@@]4([H])[C@@](C2)(NC(N4)=O)O)=CC=C1C3=O
Structure Classification
Initial Source

Cymbastela sp.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Agelastatin D Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Agelastatin D201338-45-6OthersCLL2CLL1cancer cellsJVM-2Cymbastela sp.HeLa cell linespyrrole-imidazole alkaloidchronic lymphocytic leukemiaInhibitorinhibitorinhibit

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