Aromatase-IN-1
Aromatase-IN-1 is a competitive aromatase (P450arom) inhibitor with a human IC50 of 40 nM and a Ki of 1.05 nM. Aromatase-IN-1 binds via coordination of imidazole nitrogen to the heme iron of aromatase. Aromatase-IN-1 can be used for the research of breast cancer.
For research use only. We do not sell to patients.
- CAS No.: 331684-05-0
- Formula: C17H11N3O4
- Molecular Weight:321.29
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Aromatase-IN-1 (Compound 22e) (0.040-25 μM) potently inhibits human placental aromatase with an IC50 of 0.040 μM and a Ki of 1.05 nM, achieving 99% inhibition at 25 μM[1].
Aromatase-IN-1 (2.5 μM) shows only marginal inhibition of human testicular P450 17, with 4% inhibition at 2.5 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 331684-05-0
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Molecular Weight 321.29
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Formula C17H11N3O4
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SMILES
O=C1C2=C(OC3=C1C([N+]([O-])=O)=CC=C3CN4C=NC=C4)C=CC=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Aromatase-IN-1 Related Classifications
HY-136745 Related Classifications
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