Antibacterial agent 70
Antibacterial agent 70 is an antibacterial agent that interacts with DNA, with a MIC value of 0.5 μg/mL against K. pneumonia and A. baumanii. Antibacterial agent 70 exhibits rapid bactericidal activity, low cytotoxicity to mammalian cells, and low tendency to induce drug resistance. Antibacterial agent 70 intercalates into DNA, disrupts bacterial membrane integrity, increases intracellular ROS production, reduces GSH activity, regulates membrane depolarization, enhances outer membrane permeability, and induces inner membrane damage. Antibacterial agent 70 can be used in studies related to multidrug-resistant bacterial infections and infections caused by drug-resistant Gram-negative pathogens.
For research use only. We do not sell to patients.
- Formula: C25H32ClN7O6S
- Molecular Weight:594.08
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | CC50 |
40 mg/mL
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Cytotoxicity against human HepG2 hepatocellular carcinoma cells assessed as cell viability remaining above 50% at tested concentrations.
Cytotoxicity against human HepG2 hepatocellular carcinoma cells assessed as cell viability remaining above 50% at tested concentrations.
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35168152 |
Antibacterial agent 70 (Compound 8b) (0.5 - 256 μg/mL; 12 h) potently inhibits the growth of a variety of Gram-positive and Gram-negative strains, with the strongest activity against K. pneumonia, P. aeruginosa 27853 and A. baumanii, and an MIC of 0.5 mg/mL[1].
Antibacterial agent 70 (0.5-2 mg/mL; 1-6 h) exhibits rapid, dose-dependent bactericidal activity against K. pneumonia and A. baumanii[1].
Antibacterial agent 70 (0.25 mg/mL; 16 consecutive passages) shows a low tendency to induce drug resistance in A. baumanii and K. pneumonia[1].
Antibacterial agent 70 (0.5-3 mg/mL; 24 h) dose-dependently inhibits biofilm formation and disrupts preformed biofilms of A. baumanii and K. pneumonia[1].
Antibacterial agent 70 (0.25-2 mg/mL; 100 min) induces concentration-dependent and time-dependent cytoplasmic membrane depolarization and increases outer membrane permeability in A. baumanii and K. pneumonia[1].
Antibacterial agent 70 (0.25-2 mg/mL; 4-8 h) disrupts inner membrane integrity in K. pneumonia and A. baumanii, and induces cell lysis in K. pneumonia[1].
Antibacterial agent 70 (0.5-4 mg/mL; 6-8 h) promotes the accumulation of intracellular reactive oxygen species (ROS) and reduces the activity of intracellular glutathione (GSH) in K. pneumonia and A. baumanii[1].
Antibacterial agent 70 (8-512 mg/mL; 1 h) exhibits extremely low hemolytic activity in human red blood cells (RBCs) and maintains the integrity of red blood cell membranes[1].
Antibacterial agent 70 (10-100 μg/mL; 48 h) exhibits extremely low cytotoxicity in human hepatocellular carcinoma cells (HepG2) and endothelial cells (ECs)[1].
Antibacterial agent 70 (23.3-93.2 nM) binds to DNA in the calf thymus DNA system, and exerts the effect of competitively displacing acridine orange (AO) to intercalate into DNA in the AO (HY-101879)-DNA system[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2 and ECs
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Concentration:10, 20, 40, 80, 100 μg/mL
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Incubation Time:48 h
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Result:Demonstrated no obvious cytotoxicity, maintaining a relatively high cell viability rate near the highest tested concentrations.
Key Biological Information: 50% Cytotoxic Concentration (CC50) > 40 μg/mL.
Chemical Information
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Molecular Weight 594.08
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Formula C25H32ClN7O6S
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SMILES
CCCCC1=NC(Cl)=C(N1)C2NC(NC(CN(S(=O)(C3=CC=C(C=C3)N)=O)C4CC(C)=NO4)=C2C(OCC)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antibacterial agent 70 Related Classifications
HY-144255 Related Classifications
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