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Results for "

aldose reductase inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aldose Reductase (100) Adrenergic Receptor (4) Akt (2) Apoptosis (10) Autophagy (4) c-Myc (2) Carbonic Anhydrase (1) Caspase (2) COX (1) Cytochrome P450 (3) DNA Alkylator/Crosslinker (1) Drug Derivative (1) Endogenous Metabolite (1) Environmental Pollutants (1) Fatty Acid Synthase (FASN) (1) Glycosidase (1) GSK-3 (2) Heme Oxygenase (HO) (2) Influenza Virus (2) Isotope-Labeled Compounds (2) Mitochondrial Metabolism (3) Mitophagy (3) Na+/K+ ATPase (1) Neurokinin Receptor (2) NF-κB (1) p38 MAPK (2) PDGFR (1) Phosphatase (1) Reactive Oxygen Species (ROS) (6) Reference Standards (17) SOD (3) Topoisomerase (2) α-synuclein (2) β-catenin (2)
By Research Areas:	Cancer (23) Cardiovascular Disease (7) Endocrinology (7) Infection (5) Inflammation/Immunology (22) Metabolic Disease (82) Neurological Disease (13)

By Targets:

Aldose Reductase (100)

Adrenergic Receptor (4)

Akt (2)

Apoptosis (10)

Autophagy (4)

c-Myc (2)

Carbonic Anhydrase (1)

Caspase (2)

COX (1)

Cytochrome P450 (3)

DNA Alkylator/Crosslinker (1)

Drug Derivative (1)

Endogenous Metabolite (1)

Environmental Pollutants (1)

Fatty Acid Synthase (FASN) (1)

Glycosidase (1)

GSK-3 (2)

Heme Oxygenase (HO) (2)

Influenza Virus (2)

Isotope-Labeled Compounds (2)

Mitochondrial Metabolism (3)

Mitophagy (3)

Na+/K+ ATPase (1)

Neurokinin Receptor (2)

NF-κB (1)

p38 MAPK (2)

PDGFR (1)

Phosphatase (1)

Reactive Oxygen Species (ROS) (6)

Reference Standards (17)

SOD (3)

Topoisomerase (2)

α-synuclein (2)

β-catenin (2)

By Research Areas:

Cancer (23)

Cardiovascular Disease (7)

Endocrinology (7)

Infection (5)

Inflammation/Immunology (22)

Metabolic Disease (82)

Neurological Disease (13)

110

Inhibitors & Agonists

Fluorescent Dyes

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Aldose Reductase Quinone Reductase 5 alpha Reductase Carbonyl Reductase Glutathione Reductase (GR) TrxR Dihydrofolate reductase (DHFR) HMG-CoA Reductase (HMGCR) GSNOR VKOR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-66009

Epalrestat 5+ Cited Publications ONO2235	Aldose Reductase	Metabolic Disease Inflammation/Immunology Cancer
Epalrestat is an orally active aldose reductase inhibitor that acts on diabetic neuropathy .

HY-N0102

Isoliquiritigenin Maximum Cited Publications 31 Publications Verification GU17; ISL; Isoliquiritigen; SJ000286237	Aldose Reductase Influenza Virus Autophagy Apoptosis	Infection Inflammation/Immunology Cancer
Isoliquiritigenin is an anti-tumor flavonoid from the root of Glycyrrhiza uralensis Fisch., which inhibits aldose reductase with an IC₅₀ of 320 nM. Isoliquiritigenin is a potent inhibitor of influenza virus replication with an EC₅₀ of 24.7 μM.

HY-N0033

Poliumoside 5+ Cited Publications	Aldose Reductase	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Poliumoside, a caffeoylated phenylpropanoid glycoside, is isolated from Brandisia hancei stems and leaves. Poliumoside is an advanced glycation end product (AGE) formation and rat lens aldose reductase (RLAR) inhibitor, with IC₅₀s of 19.69 and 8.47 μM, respectively. Poliumoside also has antiinflammatory and antioxidant activity .

HY-133708

β-Glucogallin 1 Publications Verification Glucogallin; 1-O-Galloyl-β-D-glucose	Aldose Reductase Reactive Oxygen Species (ROS) NF-κB PDGFR SOD	Neurological Disease Metabolic Disease
β-Glucogallin is an orally active and selective aldose reductase (AKR1B1) inhibitor with an IC₅₀ value of 58 μM when using Glyceraldehyde (HY-128748) as AKR1B1 substrate. β-Glucogallin reduces ROS, PDGF, RAGE, and NF-κB. β-Glucogallin increases SOD. β-Glucogallin has antioxidant and hepatoprotective effects. β-Glucogallin can be used in retinal research .

HY-105185

Fidarestat 3 Publications Verification SNK 860	Aldose Reductase	Metabolic Disease
Fidarestat (SNK 860) is an inhibitor of aldose reductase, with IC₅₀s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively; Fidarestat (SNK 860) has the potential to treat diabetic disease.

HY-106697

Ponalrestat 1 Publications Verification ICI 128436	Aldose Reductase	Metabolic Disease
Ponalrestat (ICI 128436) is an orally active, selective and noncompetitive aldose reductase (AKR1B1; ALR) inhibitor. Ponalrestat selectively inhibits ALR2 (K_i=7.7 nM) over ALR1 (K_i=60 μM). Ponalrestat inhibits the conversion of glucose to sorbitol .

HY-B1392

Esmolol hydrochloride 3 Publications Verification	Adrenergic Receptor Caspase Apoptosis Aldose Reductase Neurokinin Receptor	Cardiovascular Disease Endocrinology Cancer
Esmolol hydrochloride is an ultra-short-acting cardioselective β1-adrenergic blocker. Esmolol hydrochloride exerts its antiarrhythmic effect by activating Neurokinin 1 Receptor. Esmolol hydrochloride attenuates post resuscitation myocardial dysfunction. Esmolol hydrochloride improves diabetic wound healing by inhibiting aldose reductase and the production of advanced glycation end products and promoting fibroblast migration. Esmolol hydrochloride can be used to study cardiac diseases such as arrhythmias and diabetic foot ulcers .

HY-16500

Tolrestat 2 Publications Verification AY-27773	Aldose Reductase	Cancer
Tolrestat is a potent, orally active aldose reductase inhibitor with IC₅₀ of 35 nM.

HY-19687

Zopolrestat 1 Publications Verification CP73850	Aldose Reductase	Metabolic Disease
Zopolrestat (CP73850) is a potent, orally active aldose reductase (AR) inhibitor with an IC₅₀ of 3.1 nM. Zopolrestat is used for the research of diabetic complications .

HY-N0310

Soyasaponin Bb 1 Publications Verification	Aldose Reductase Heme Oxygenase (HO) Reactive Oxygen Species (ROS) Apoptosis	Neurological Disease Metabolic Disease
Soyasaponin Bb is an orally active, covalent inducer of heme oxygenase HO-1 and an inhibitor of aldose reductase AKR1B1. Soyasaponin Bb can regulate oxidative stress pathways, enhance antioxidant capacity, reduce reactive oxygen species (ROS) generation, and inhibit lipid peroxidation and hepatocyte apoptosis. Soyasaponin Bb improves alcohol-induced hepatocyte membrane damage and liver function abnormalities, and improves Scopolamine (HY-N0296)-induced memory impairment. Soyasaponin Bb has antioxidant, hepatoprotective, and neuroprotective activities .

HY-129586

Govorestat AT-007	Aldose Reductase	Metabolic Disease
Govorestat (AT-007) is an orally active brain-penetrant aldose reductase inhibitor with an IC₅₀ value of 100 pM. Govorestat has the potential for galactose-1-phosphate uridyl transferase deficiency research .

HY-N4089

Quercetin 3-gentiobioside	Aldose Reductase Cytochrome P450	Metabolic Disease Cancer
Quercetin 3-gentiobioside is a flavonoid found in Artemisia iwayomogi. Quercetin 3-gentiobioside inhibits aromatase with an K_i of 46.77 nM. Quercetin 3-gentiobioside inhibits aldose reductase (AR) and the formation of advanced glycation end products (AGEs), with IC₅₀ values of 10.60 μM and 109.46 μM, respectively. Quercetin 3-gentiobioside inhibits proliferation of cancer cells and fibroblast-like synoviocytes. Quercetin 3-gentiobioside can be used for the research of cancer, such as lung carcinoma .

HY-Y0790

Cuminaldehyde 1 Publications Verification p-Isopropylbenzaldehyde	Environmental Pollutants α-synuclein	Infection Neurological Disease Inflammation/Immunology Cancer
Cuminaldehyde is the main component of Cuminum cyminum and has multiple biological activities, including anti-inflammatory, anti-cancer, anti-diabetic, anti-injury, anti-neuropathy and antibacterial effects. Cuminaldehyde is an inhibitor of aldose reductase (IC₅₀= 0.00085 mg/mL), α-glucosidase (IC₅₀=0.5 mg/mL) and lipoxygenase (IC₅₀=1370 μM). Cuminaldehyde also inhibits the fibrillation of α-synuclein and prevents its aggregation. Cuminaldehyde has potential application value in the research of neurodegenerative diseases, cancer, diabetes and neuropathic pain diseases .

HY-N1517

Ganoderic acid C2	Aldose Reductase	Inflammation/Immunology Cancer
Ganoderic acid C2 is a bioactive triterpenoid in Ganoderma lucidum. Ganoderic acid C2 possesses the potential anti-tumor bioactivity, antihistamine, anti-aging and cytotoxic effects. Ganoderic acid C2 is the inhibitor for aldose reductase with an IC₅₀ of 43.8 µM .

HY-15314

Ranirestat 1 Publications Verification AS-3201	Aldose Reductase	Neurological Disease Metabolic Disease
Ranirestat (AS-3201) potent and orally active aldose reductase (AR) inhibitor with IC₅₀s of 11 nM and 15 nM for rat lens AR and recombinant human AR, respectively, and a K_i of 0.38 nM for recombinant human AR. Ranirestat has the potential for diabetic sensorimotor polyneuropathy treatment. Ranirestat also has a neuroprotective effect on diabetic retinas .

HY-16255

Imirestat 2 Publications Verification AL 1576; Alcon 1576; HOE 843	Aldose Reductase	Metabolic Disease
Imirestat (AL 1576) is an aldose reductase inhibitor, used for the treatment of diabetes.

HY-18967

Caficrestat AT-001; aldose reductase-IN-1	Aldose Reductase	Metabolic Disease
Caficrestat (AT-001) is an orally active aldose reductase inhibitor. Caficrestat can be used in the study of diabetic cardiomyopathy .

HY-50289

Sorbinil 2 Publications Verification	Aldose Reductase	Metabolic Disease
Sorbinil is an aldose reductase inhibitor (ARI) that prevents the accumulation of sorbitol in cells or animals. Sorbinil is useful in studying diabetes and diabetic complications, reducing AR activity and inhibiting the polyol pathway.

HY-N0309

Soyasaponin Ba 1 Publications Verification	Aldose Reductase Akt GSK-3 β-catenin Reactive Oxygen Species (ROS) Mitochondrial Metabolism Apoptosis c-Myc	Metabolic Disease
Soyasaponin Ba is a soyasaponin that can be isolated from Phaseolus vulgaris, acts as an aldose reductase inhibitor (ARI). Soyasaponin Ba activates Akt/GSK3β/β-catenin signaling pathway, reduces lipid accumulation, lowers ROS generation, improves mitochondrial membrane potential, ATP levels, and morphology, and inhibits apoptosis. Soyasaponin Ba can be used for the research of lipid accumulation and secondary diabetic complications .

HY-151231

6-Hydroxyluteolin	Aldose Reductase	Neurological Disease Metabolic Disease
6-Hydroxyluteolin (Compound 17) is a flavonoid derivative and also an inhibitor of Aldose reductase, with an experimental -log IC₅₀ value of 6.690. 6-Hydroxyluteolin can be isolated from the leaves of multiple plant families, including Plantaginaceae, Globulariaceae and Labiatae. 6-Hydroxyluteolin serves as a phylogenetic marker for higher plants. 6-Hydroxyluteolin can be used in the research of diabetic cataract .

HY-120208

MK204	Aldose Reductase	Metabolic Disease
MK204 is an aldose reductase (AR) inhibitor that can be used in diabetes research .

HY-13633

Exisulind 2 Publications Verification	Aldose Reductase	Metabolic Disease Cancer
Exisulind is an inactive metabolite of the nonsteroidal, anti-inflammatory agent sulindac . Exisulind inhibits aldose reductase with an IC₅₀ of 367 nM in vitro and may contribute to the beneficial pharmacological effects of sulindac on type 2 diabetic complications .

HY-122917

Danshenol A	Aldose Reductase Reactive Oxygen Species (ROS)	Cardiovascular Disease Inflammation/Immunology Cancer
Danshenol A, an abietane-type diterpenoid, is an aldose reductase (AR) inhibitor with an IC₅₀ of 0.1 μM. Danshenol A can protect endothelial cells from oxidative stress by directly scavenging ROS. Danshenol A has anti-inflammatory and antitumor properties. Danshenol A can be used for atherosclerosis research .

HY-16433

Risarestat CT 112	Aldose Reductase	Metabolic Disease Inflammation/Immunology
Risarestat (CT-112), an aldose reductase inhibitor, is developed for the treatment of diabetic complications.

HY-116239

Zenarestat 1 Publications Verification	Aldose Reductase	Neurological Disease Metabolic Disease
Zenarestat is a potent and orally active aldose reductase inhibitor. Zenarestat improves diabetic peripheral neuropathy in Zucker diabetic fatty rats .

HY-N0075

(Rac)-Byakangelicin	Others	Metabolic Disease
(Rac)-Byakangelicin is a racemate of Byakangelicin mainly isolated from the genus Angelica. Byakangelicin is an aldose-reductase inhibitor with an IC₅₀ value of 6.2 μM .

HY-B1202

Alrestatin 1 Publications Verification AY-22284	Aldose Reductase	Metabolic Disease
Alrestatin (AY-22284) is an aldose reductase inhibitor. Alrestatin reduces fructose levels in the uterine fluid of mice. Alrestatin interferes with sperm capacitation and impairs fertilization function in mice. Alrestatin decreases basal and tyramine-induced norepinephrine release in rat pancreatic specimens in vitro. Alrestatin enhances glucose- and arginine-stimulated insulin secretion in vivo. Alrestatin can be used in studies related to diabetes and reproductive diseases .

HY-W601605

Methosorbinil	Aldose Reductase	Endocrinology
Methosorbinil is an aldose reductase inhibitor with anti-cataract activity .

HY-66009R

Epalrestat (Standard) ONO2235 (Standard)	Reference Standards Aldose Reductase	Metabolic Disease Inflammation/Immunology Cancer
Epalrestat (Standard) is the analytical standard of Epalrestat. This product is intended for research and analytical applications. Epalrestat is an orally active aldose reductase inhibitor that acts on diabetic neuropathy .

HY-162325

WJ-39	Aldose Reductase Mitochondrial Metabolism Apoptosis Mitophagy	Metabolic Disease
WJ-39 is an orally active aldose reductase (AR) inhibitor. WJ-39 improves tubular damage in diabetic nephropathy rats by activating PINK1/Parkin signaling, promoting mitophagy, and attenuating apoptosis .

HY-105629

Populin Salicin 6-benzoate; NSC 128308	Drug Derivative	Others
Populin, a Salicin (HY-N0149) derivative, is a glucoside found in the fallen leaves of Populus alba × P. berolinensis .

HY-W319094

4′-Hydroxyflavone	Aldose Reductase
4′-Hydroxyflavone (compound 50) can inhibit aldose reductase, with IC₅₀ 12 μM .

HY-16500R

Tolrestat (Standard) AY-27773 (Standard)	Reference Standards Aldose Reductase	Cancer
Tolrestat (Standard) is the analytical standard of Tolrestat. This product is intended for research and analytical applications. Tolrestat is a potent, orally active aldose reductase inhibitor with IC₅₀ of 35 nM.

HY-106915

SG-210 SPR 210	Aldose Reductase	Neurological Disease Metabolic Disease
SG-210 (SPR 210) is an orally active and selective aldose reductase (AR) inhibitor. SG-210 has IC₅₀ values of 9.5 nM and 10 nM for AR from porcine lens and human placenta, respectively. SG-210 can inhibit sorbitol accumulation and ameliorate diabetic neuropathy and retinopathy in Streptozotocin (HY-13753)-induced diabetic rats. SG-210 can be used in the research of diseases such as diabetes-related complications .

HY-N9898

Sinocrassoside C1	Others	Others
Sinocrassoside C1 is a natural compound isolated from themethanolic extract of the whole plant ofSinocrassula indica (Crassulaceae) .

HY-100969

EBPC	Aldose Reductase	Metabolic Disease
EBPC is a potent and selective aldose reductase inhibitor with an IC₅₀ of 47 nM .

HY-106877

Minalrestat ARI-509; WAY-ARI 509	Aldose Reductase	Metabolic Disease
Minalrestat (ARI-509) is a potent and orally active aldose reductase inhibitor. Minalrestat can be used in the research of diabetes .

HY-175854

Aldose reductase-IN-9	Aldose Reductase	Cancer
Aldose reductase-IN-9 (Compound 8b) is an Aldose reductase (ALR2) inhibitor with a K_i value of 3.59 nM. Aldose reductase-IN-9 has anti-tumor activity .

HY-N12313

Corybulbine	Aldose Reductase	Metabolic Disease
Corybulbine, an alkaloid that can be isolated from the methanolic extract of Corydalis ternata, is an aldose reductase (ALR2) inhibitor. Corybulbine can be used for diabetic complications research .

HY-121933

IDD388	Aldose Reductase	Metabolic Disease
IDD388 is a selective aldose reductase (ALR2) inhibitor with an IC₅₀ of 30 nM. IDD388 displays selectivity for ALR2 over ALR1 (IC₅₀ of 14 μM) .

HY-119842

ALO1567 AL1567	Aldose Reductase	Endocrinology
ALO1567 (AL1567) is an orally available aldose reductase inhibitor with an IC₅₀ of 27 nM for rat lens aldose reductase. ALO1567 can be used in the research of diabetes .

HY-N0102R

Isoliquiritigenin (Standard) GU17 (Standard); ISL (Standard); Isoliquiritigen (Standard); SJ000286237 (Standard)	Reference Standards Aldose Reductase Influenza Virus Autophagy Apoptosis	Infection Inflammation/Immunology Cancer
Isoliquiritigenin (Standard) is the analytical standard of Isoliquiritigenin. This product is intended for research and analytical applications. Isoliquiritigenin is an anti-tumor flavonoid from the root of Glycyrrhiza uralensis Fisch., which inhibits aldose reductase with an IC50 of 320 nM. Isoliquiritigenin is a potent inhibitor of influenza virus replication with an EC50 of 24.7 μM.

HY-113738

ADN 138	Aldose Reductase Na+/K+ ATPase Endogenous Metabolite	Neurological Disease Metabolic Disease
ADN-138 is an aldose reductase inhibitor. ADN-138 reduces sorbitol levels in diabetic nerves and results in significant increases in MNCV and Na ⁺, K ⁺-ATPase in the nerves. ADN-138 can be used in the research of diabetic nerve complications .

HY-147977

ALR1/2-IN-1	Aldose Reductase	Cancer
ALR1/2-IN-1 (Compound 6e) is an aldehyde reductase (ALR1) and aldose reductase (ALR2) inhibitor with IC₅₀ values of 3.26 μM and 3.06 μM against ALR1 and ALR2, respectively. ALR1/2-IN-1 shows anticancer activity .

HY-116600

AL-4114	Aldose Reductase	Metabolic Disease
AL-4114 is an aldose reductase inhibitor which can be utilized in research related to the prevention of diabetic cataractogenesis .

HY-175331

ALR2-IN-7	Aldose Reductase	Metabolic Disease Cancer
ALR2-IN-7 (Compound 5a) is a highly potent and selective aldose reductase (ALR2/AKR1B1) inhibitor (K_i=8.71 nM). ALR2-IN-7 is promising for research of diabetic complications (e.g., retinopathy, nephropathy) and cancers .

HY-N6883

6-Methoxytricin	Aldose Reductase	Metabolic Disease
6-Methoxytricin (Compound 6) is an flavonoid isolated from Artemisia iwayomogi. 6-Methoxytricin (Compound 6) is an inhibitor on aldose reductase (AR) and advanced glycation endproduct (AGE) formation activities with IC₅₀ values of 30.29 μM and 134.88 μM, respectively. 6-Methoxytricin (Compound 6) has potential as an anti-diabetic complications agent .

HY-116508

MK 319	Aldose Reductase	Metabolic Disease
MK 319 is a selective aldose reductase (AR) inhibitor with an IC₅₀ of 0.3 μM. MK 319 can be utilized in diabetes research .

HY-W011786

2-Chloro-1-(4-fluorobenzyl)-1H-benzo[d]imidazole	Aldose Reductase	Metabolic Disease
2-Chloro-1-(4-fluorobenzyl)-1H-benzo[d]imidazole is an inhibitor of larval settlement in marine organisms, demonstrating low toxicity while effectively inhibiting the metamorphosis of species such as barnacles, bryozoans, and polychaetes. 2-Chloro-1-(4-fluorobenzyl)-1H-benzo[d]imidazole also exhibits activity as an aldose reductase (ALR2) inhibitor, indicating potential therapeutic applications in diabetes-related complications.

HY-122177

MK181	Aldose Reductase	Cancer
MK181 is an aldose reductase (AR) inhibitor with IC₅₀s of 0.71 μM and 4.5 μM for aldose reductase and AKR1B10, respectively. MK181 can bind into the external loop A subpocket of AKR1B10 .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0102

Isoliquiritigenin Maximum Cited Publications 31 Publications Verification GU17; ISL; Isoliquiritigen; SJ000286237	Classification of Application Fields Plants Infection Chalcones Flavonoids Microorganisms Leguminosae Phenols Polyphenols Glycyrrhiza uralensis Fisch. Inflammation/Immunology Disease Research Fields Source Classification	Aldose Reductase Influenza Virus Autophagy Apoptosis
Isoliquiritigenin is an anti-tumor flavonoid from the root of Glycyrrhiza uralensis Fisch., which inhibits aldose reductase with an IC₅₀ of 320 nM. Isoliquiritigenin is a potent inhibitor of influenza virus replication with an EC₅₀ of 24.7 μM.

HY-N0033

Poliumoside 5+ Cited Publications	Cardiovascular Disease Classification of Application Fields Callicarpa formosana Rolfe Plants Simple Phenylpropanols Verbenaceae Phenols Polyphenols Scrophulariaceae Phenylpropanoids Inflammation/Immunology Disease Research Fields Brandisia hancei Hook. f. Source Classification	Aldose Reductase
Poliumoside, a caffeoylated phenylpropanoid glycoside, is isolated from Brandisia hancei stems and leaves. Poliumoside is an advanced glycation end product (AGE) formation and rat lens aldose reductase (RLAR) inhibitor, with IC₅₀s of 19.69 and 8.47 μM, respectively. Poliumoside also has antiinflammatory and antioxidant activity .

HY-133708

β-Glucogallin 1 Publications Verification Glucogallin; 1-O-Galloyl-β-D-glucose	Structural Classification Phyllanthaceae Phenols Polyphenols Phyllanthus emblica L. Plants Source Classification	Aldose Reductase Reactive Oxygen Species (ROS) NF-κB PDGFR SOD
β-Glucogallin is an orally active and selective aldose reductase (AKR1B1) inhibitor with an IC₅₀ value of 58 μM when using Glyceraldehyde (HY-128748) as AKR1B1 substrate. β-Glucogallin reduces ROS, PDGF, RAGE, and NF-κB. β-Glucogallin increases SOD. β-Glucogallin has antioxidant and hepatoprotective effects. β-Glucogallin can be used in retinal research .

HY-N0310

Soyasaponin Bb 1 Publications Verification	Triterpenes Classification of Application Fields Leguminosae Glycine max (L.) merr Terpenoids Plants Disease Research Fields Endocrinology Source Classification	Aldose Reductase Heme Oxygenase (HO) Reactive Oxygen Species (ROS) Apoptosis
Soyasaponin Bb is an orally active, covalent inducer of heme oxygenase HO-1 and an inhibitor of aldose reductase AKR1B1. Soyasaponin Bb can regulate oxidative stress pathways, enhance antioxidant capacity, reduce reactive oxygen species (ROS) generation, and inhibit lipid peroxidation and hepatocyte apoptosis. Soyasaponin Bb improves alcohol-induced hepatocyte membrane damage and liver function abnormalities, and improves Scopolamine (HY-N0296)-induced memory impairment. Soyasaponin Bb has antioxidant, hepatoprotective, and neuroprotective activities .

HY-N4089

Quercetin 3-gentiobioside	Flavonols Structural Classification Flavonoids other families Classification of Application Fields Phenols Polyphenols Metabolic Disease Plants Disease Research Fields Source Classification	Aldose Reductase Cytochrome P450
Quercetin 3-gentiobioside is a flavonoid found in Artemisia iwayomogi. Quercetin 3-gentiobioside inhibits aromatase with an K_i of 46.77 nM. Quercetin 3-gentiobioside inhibits aldose reductase (AR) and the formation of advanced glycation end products (AGEs), with IC₅₀ values of 10.60 μM and 109.46 μM, respectively. Quercetin 3-gentiobioside inhibits proliferation of cancer cells and fibroblast-like synoviocytes. Quercetin 3-gentiobioside can be used for the research of cancer, such as lung carcinoma .

HY-Y0790

Cuminaldehyde 1 Publications Verification p-Isopropylbenzaldehyde	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Rudbeckia laciniata L. Umbelliferae Plants Endogenous metabolite Disease Research Fields Source Classification Cancer	Environmental Pollutants α-synuclein
Cuminaldehyde is the main component of Cuminum cyminum and has multiple biological activities, including anti-inflammatory, anti-cancer, anti-diabetic, anti-injury, anti-neuropathy and antibacterial effects. Cuminaldehyde is an inhibitor of aldose reductase (IC₅₀= 0.00085 mg/mL), α-glucosidase (IC₅₀=0.5 mg/mL) and lipoxygenase (IC₅₀=1370 μM). Cuminaldehyde also inhibits the fibrillation of α-synuclein and prevents its aggregation. Cuminaldehyde has potential application value in the research of neurodegenerative diseases, cancer, diabetes and neuropathic pain diseases .

HY-N0311

Emodin-8-glucoside 2 Publications Verification	Quinones other families Classification of Application Fields Anthraquinones Phenols Polyphenols Plants Disease Research Fields Source Classification Cancer	Aldose Reductase Topoisomerase SOD p38 MAPK
Emodin-8-glucoside is an anthraquinone derivative that can be isolated from Aloe vera. Emodin-8-glucoside is the inhibitor for MAPK with an inhibition constant of 430.14 pM. Emodin-8-glucoside exhibits moderate inhibitory activity against rat lens aldose reductase (ALAR) and topoisomerases II with IC₅₀s of 14.4 μM and 66 μM. Emodin-8-glucoside exhibits antioxidant, anti-inflammatory and anti-fibrotic activities. Emodin-8-glucoside can cross the blood brain barrier .

HY-N1517

Ganoderic acid C2	Triterpenes Microorganisms Classification of Application Fields Terpenoids Polyporaceae Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants Disease Research Fields Source Classification Cancer	Aldose Reductase
Ganoderic acid C2 is a bioactive triterpenoid in Ganoderma lucidum. Ganoderic acid C2 possesses the potential anti-tumor bioactivity, antihistamine, anti-aging and cytotoxic effects. Ganoderic acid C2 is the inhibitor for aldose reductase with an IC₅₀ of 43.8 µM .

HY-N0309

Soyasaponin Ba 1 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Leguminosae Glycine max (L.) merr Terpenoids Metabolic Disease Plants Disease Research Fields Source Classification	Aldose Reductase Akt GSK-3 β-catenin Reactive Oxygen Species (ROS) Mitochondrial Metabolism Apoptosis c-Myc
Soyasaponin Ba is a soyasaponin that can be isolated from Phaseolus vulgaris, acts as an aldose reductase inhibitor (ARI). Soyasaponin Ba activates Akt/GSK3β/β-catenin signaling pathway, reduces lipid accumulation, lowers ROS generation, improves mitochondrial membrane potential, ATP levels, and morphology, and inhibits apoptosis. Soyasaponin Ba can be used for the research of lipid accumulation and secondary diabetic complications .

HY-122917

Danshenol A	Terpenoids Labiatae Samanea saman (Jacq.) Merr. Diterpenoids Plants	Aldose Reductase Reactive Oxygen Species (ROS)
Danshenol A, an abietane-type diterpenoid, is an aldose reductase (AR) inhibitor with an IC₅₀ of 0.1 μM. Danshenol A can protect endothelial cells from oxidative stress by directly scavenging ROS. Danshenol A has anti-inflammatory and antitumor properties. Danshenol A can be used for atherosclerosis research .

HY-N0075

(Rac)-Byakangelicin	Classification of Application Fields Ruta graveolens Linn. Rutaceae Coumarins Metabolic Disease Phenylpropanoids Plants Disease Research Fields Source Classification	Others
(Rac)-Byakangelicin is a racemate of Byakangelicin mainly isolated from the genus Angelica. Byakangelicin is an aldose-reductase inhibitor with an IC₅₀ value of 6.2 μM .

HY-105629

Populin Salicin 6-benzoate; NSC 128308	Structural Classification Melicope bonwickii (F.Muell.) T.G.Hartley Plants Saccharides Monosaccharides Salicaceae Source Classification	Drug Derivative
Populin, a Salicin (HY-N0149) derivative, is a glucoside found in the fallen leaves of Populus alba × P. berolinensis .

HY-N9898

Sinocrassoside C1	Structural Classification Flavonols Sinocrassula indica (Decne.) Berger Flavonoids Crassulaceae Plants Source Classification	Others
Sinocrassoside C1 is a natural compound isolated from themethanolic extract of the whole plant ofSinocrassula indica (Crassulaceae) .

HY-N12313

Corybulbine	Structural Classification Alkaloids Corydalis cava (L.) Schweigg. & Körte Quinoline Alkaloids Plants Papaveraceae Source Classification	Aldose Reductase
Corybulbine, an alkaloid that can be isolated from the methanolic extract of Corydalis ternata, is an aldose reductase (ALR2) inhibitor. Corybulbine can be used for diabetic complications research .

HY-N0102R

Isoliquiritigenin (Standard) GU17 (Standard); ISL (Standard); Isoliquiritigen (Standard); SJ000286237 (Standard)	Structural Classification Chalcones Flavonoids Microorganisms Leguminosae Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch. Source Classification	Reference Standards Aldose Reductase Influenza Virus Autophagy Apoptosis
Isoliquiritigenin (Standard) is the analytical standard of Isoliquiritigenin. This product is intended for research and analytical applications. Isoliquiritigenin is an anti-tumor flavonoid from the root of Glycyrrhiza uralensis Fisch., which inhibits aldose reductase with an IC50 of 320 nM. Isoliquiritigenin is a potent inhibitor of influenza virus replication with an EC50 of 24.7 μM.

HY-N6883

6-Methoxytricin	Flavonoids other families Classification of Application Fields Flavones Phenols Polyphenols Metabolic Disease Plants Disease Research Fields Source Classification	Aldose Reductase
6-Methoxytricin (Compound 6) is an flavonoid isolated from Artemisia iwayomogi. 6-Methoxytricin (Compound 6) is an inhibitor on aldose reductase (AR) and advanced glycation endproduct (AGE) formation activities with IC₅₀ values of 30.29 μM and 134.88 μM, respectively. 6-Methoxytricin (Compound 6) has potential as an anti-diabetic complications agent .

HY-N0310R

Soyasaponin Bb (Standard)	Triterpenes Structural Classification Leguminosae Glycine max (L.) merr Terpenoids Plants Source Classification	Reference Standards Aldose Reductase Heme Oxygenase (HO) Reactive Oxygen Species (ROS) Apoptosis
Soyasaponin Bb (Standard) is the analytical standard of Soyasaponin Bb (HY-N0310). This product is intended for research and analytical applications. Soyasaponin Bb is an orally active, covalent inducer of heme oxygenase HO-1 and an inhibitor of aldose reductase AKR1B1. Soyasaponin Bb can regulate oxidative stress pathways, enhance antioxidant capacity, reduce reactive oxygen species (ROS) generation, and inhibit lipid peroxidation and hepatocyte apoptosis. Soyasaponin Bb improves alcohol-induced hepatocyte membrane damage and liver function abnormalities, and improves Scopolamine (HY-N0296)-induced memory impairment. Soyasaponin Bb has antioxidant, hepatoprotective, and neuroprotective activities .

HY-Y0790R

Cuminaldehyde (Standard) p-Isopropylbenzaldehyde (Standard)	Structural Classification Ketones, Aldehydes, Acids Rudbeckia laciniata L. Umbelliferae Plants Endogenous metabolite Source Classification	α-synuclein Reference Standards
Cuminaldehyde Standard is the analytical standard of Cuminaldehyde. This product is intended for research and analytical applications. Cuminaldehyde is the main component of Cuminum cyminum and has multiple biological activities, including anti-inflammatory, anti-cancer, anti-diabetic, anti-injury, anti-neuropathy and antibacterial effects. Cuminaldehyde is an inhibitor of aldose reductase (IC₅₀= 0.00085 mg/mL) and α-glucosidase (IC₅₀=0.5 mg/mL). Cuminaldehyde also inhibits the fibrillation of α-synuclein and prevents its aggregation Cuminaldehyde can induce apoptosis in colon adenocarcinoma cells by targeting topoisomerase I and II. In addition, Cuminaldehyde also exerts anti-inflammatory activity by inhibiting lipoxygenase. Cuminaldehyde has a strong inhibitory effect on the growth of Aspergillus flavus and the biosynthesis of aflatoxin B1 (AFB1). Cuminaldehyde can exert anti-injury and anti-neuropathy effects by participating in opioid receptors, L-arginine/NO/cGMP pathways and anti-inflammatory effects. Cuminaldehyde has potential application value in the research of neurodegenerative diseases, cancer, diabetes and neuropathic pain diseases .

HY-N14447

Salfredin A3	Natural Products Microorganisms Source Classification	Aldose Reductase
Salfredin A3 is an aldose reductase inhibitor .

HY-N14431

Salfredin C2	Natural Products Microorganisms Source Classification	Aldose Reductase
Salfredin C2 is an aldose reductase inhibitor .

HY-N14451

Salfredin C1	Natural Products Microorganisms Source Classification	Aldose Reductase
Salfredin C1 is an aldose reductase inhibitor .

HY-N14401

Salfredin B11	Natural Products Microorganisms Source Classification	Aldose Reductase
Salfredin B11 is an aldose reductase inhibitor .

HY-N14419

Salfredin C3	Natural Products Microorganisms Source Classification	Aldose Reductase
Salfredin C3 is an aldose reductase inhibitor .

HY-N14449

Salfredin A4	Natural Products Microorganisms Source Classification	Aldose Reductase
Salfredin A4 is an aldose reductase inhibitor .

HY-N14450

Salfredin A7	Monophenols Microorganisms Phenols Source Classification	Aldose Reductase
Salfredin A7 is an aldose reductase inhibitor .

HY-N2494

Hydroxyevodiamine	Alkaloids other families Classification of Application Fields Plants Inflammation/Immunology Disease Research Fields Indole Alkaloids Source Classification	Aldose Reductase
Hydroxyevodiamine inhibits aldose reductase with an IC₅₀ value of 24.1 μM .

HY-N14186

Asperaldin	Quinones Structural Classification Microorganisms Naphthalene Quinones Source Classification	Aldose Reductase
Asperaldin is a potent aldose reductase (RLAR) inhibitor found in Aspergillus niger CFR-1046 .

HY-N13759

Mumeose K	Natural Products Rosaceae Prunus mume Siebold & Zucc. Plants Source Classification	Aldose Reductase
Mumeose K is the inhibitor for aldose reductase with an IC₅₀ of 27 μM. Mumeose K exhibits potential anti-diabetic activity, and can be used in research about diabetes-related complication .

HY-N11639

Ganoderic acid Df	Triterpenes Microorganisms Terpenoids Source Classification	Aldose Reductase
Ganoderic acid Df is a lanostane-type triterpenoid, that can be isolated from the fruiting body of Ganoderma lucidum. Ganoderic acid Df potently inhibits aldose reductase, with an IC₅₀ of 22.8 ± 0.6 μM .

HY-N12871

Floramanoside D	Malvaceae Flavonoids Flavones Abelmoschus manihot (Linn.) Medicus Plants Source Classification	Aldose Reductase
Floramanoside D is a flavonol glycoside. Floramanoside D inhibits aldose reductase (IC₅₀ is 2.2 μM), scavenges the 2,2-diphenyl-1-picrylhydrazyl (DPPH) (SC₅₀ is 12.5 μM) .

HY-N0075R

(Rac)-Byakangelicin (Standard)	Structural Classification Ruta graveolens Linn. Rutaceae Coumarins Phenylpropanoids Plants Source Classification	Reference Standards Others
(Rac)-Byakangelicin (Standard) is the analytical standard of (Rac)-Byakangelicin. This product is intended for research and analytical applications. (Rac)-Byakangelicin is a racemate of Byakangelicin mainly isolated from the genus Angelica. Byakangelicin is an aldose-reductase inhibitor with an IC₅₀ value of 6.2 μM .

HY-W715538

Rhetsinine	Alkaloids Evodia rutaecarpa (Juss.) Benth. Rutaceae Plants Indole Alkaloids Source Classification	Aldose Reductase
Rhetsinine is an aldose reductase inhibitor isolated from Evodia rutaecarpa, exhibiting an IC₅₀ value of 24.1 μM. At a concentration of 100 μM, rhetsinine significantly inhibits sorbitol accumulation by 79.3%. This compound shows potential for research in diabetic complications, including diabetic neuropathy and retinopathy .

HY-N1517R

Ganoderic acid C2 (Standard)	Triterpenes Structural Classification Microorganisms Terpenoids Polyporaceae Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants Source Classification	Aldose Reductase Reference Standards
Ganoderic acid C2 (Standard) is the analytical standard of Ganoderic acid C2. This product is intended for research and analytical applications. Ganoderic acid C2 is a bioactive triterpenoid in Ganoderma lucidum. Ganoderic acid C2 possesses the potential anti-tumor bioactivity, antihistamine, anti-aging and cytotoxic effects. Ganoderic acid C2 is the inhibitor for aldose reductase with an IC₅₀ of 43.8 µM .

HY-N3716

Dehydroglyasperin D	Leguminosae Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch. Source Classification	Aldose Reductase COX
Dehydroglyasperin D inhibits rat and human Aldose Reductase (AR) (IC₅₀: 62.4 μM and 176.2 μM respectively). Dehydroglyasperin D has anti-obesity, antioxidant effects. Dehydroglyasperin D shows anti-inflammatory activity by inhibiting COX-2 expression and the MLK3 signaling pathway. Dehydroglyasperin D also inhibits melanin synthesis. Dehydroglyasperin D is a prenylated flavonoid that can be isolated from Glycyrrhiza uralensi .

HY-N0033R

Poliumoside (Standard)	Structural Classification Simple Phenylpropanols Verbenaceae Phenols Polyphenols Scrophulariaceae Callicarpa formosana Rolfe Phenylpropanoids Plants Brandisia hancei Hook. f. Source Classification	Reference Standards Aldose Reductase
Poliumoside (Standard) is the analytical standard of Poliumoside. This product is intended for research and analytical applications. Poliumoside, a caffeoylated phenylpropanoid glycoside, is isolated from Brandisia hancei stems and leaves. Poliumoside is an advanced glycation end product (AGE) formation and rat lens aldose reductase (RLAR) inhibitor, with IC₅₀s of 19.69 and 8.47 μM, respectively. Poliumoside also has antiinflammatory and antioxidant activity .

HY-N0309R

Soyasaponin Ba (Standard)	Triterpenes Structural Classification Leguminosae Glycine max (L.) merr Terpenoids Plants Source Classification	Reference Standards Aldose Reductase Akt GSK-3 β-catenin Reactive Oxygen Species (ROS) Mitochondrial Metabolism Apoptosis c-Myc
Soyasaponin Ba (Standard) is the analytical standard of Soyasaponin Ba (HY-N0309). Soyasaponin Ba is a soyasaponin that can be isolated from Phaseolus vulgaris, acts as an aldose reductase inhibitor (ARI). Soyasaponin Ba activates Akt/GSK3β/β-catenin signaling pathway, reduces lipid accumulation, lowers ROS generation, improves mitochondrial membrane potential, ATP levels, and morphology, and inhibits apoptosis. Soyasaponin Ba can be used for the research of lipid accumulation and secondary diabetic complications .

HY-N4089R

Quercetin 3-gentiobioside (Standard)	Flavonols Structural Classification Flavonoids other families Phenols Polyphenols Plants Source Classification	Reference Standards Aldose Reductase Cytochrome P450
Quercetin 3-gentiobioside (Standard) is the analytical standard of Quercetin 3-gentiobioside (HY-N4089). This product is intended for research and analytical applications. Quercetin 3-gentiobioside is a flavonoid found in Artemisia iwayomogi. Quercetin 3-gentiobioside inhibits aromatase with an K_i of 46.77 nM. Quercetin 3-gentiobioside inhibits aldose reductase (AR) and the formation of advanced glycation end products (AGEs), with IC₅₀ values of 10.60 μM and 109.46 μM, respectively. Quercetin 3-gentiobioside inhibits proliferation of cancer cells and fibroblast-like synoviocytes. Quercetin 3-gentiobioside can be used for the research of cancer, such as lung carcinoma .

HY-N0311R

Emodin-8-glucoside (Standard)	Quinones Structural Classification other families Anthraquinones Phenols Polyphenols Plants Source Classification	Reference Standards Aldose Reductase Topoisomerase SOD p38 MAPK
Emodin-8-glucoside (Standard) is the analytical standard of Emodin-8-glucoside. This product is intended for research and analytical applications. Emodin-8-glucoside is an anthraquinone derivative that can be isolated from Aloe vera. Emodin-8-glucoside is the inhibitor for MAPK with an inhibition constant of 430.14 pM. Emodin-8-glucoside exhibits moderate inhibitory activity against rat lens aldose reductase (ALAR) and topoisomerases II with IC₅₀s of 14.4 μM and 66 μM. Emodin-8-glucoside exhibits antioxidant, anti-inflammatory and anti-fibrotic activities. Emodin-8-glucoside can cross the blood brain barrier .

HY-N17737

Floramanoside F	Malvaceae Structural Classification Flavonols Flavonoids Abelmoschus manihot (Linn.) Medicus Plants Source Classification	Fatty Acid Synthase (FASN) Cytochrome P450
Floramanoside F is a type of flavonol glycoside compound. Floramanoside F has a moderate free radical scavenging effect, with a SC₅₀ value of 25.1 μM. Floramanoside F has a relatively weak inhibitory activity on aldose reductase, with a IC₅₀ value greater than 100 μM. Floramanoside F has strong binding affinity with key target enzymes of type 1 diabetic nephropathy (T1DN) (Fasn, Cyp2e1, Cyp4a32), and can inhibit lipid accumulation and oxidative stress, thereby alleviating renal inflammation and fibrosis. Floramanoside F can be used to study type 1 diabetic nephropathy and diabetic complications .

Cat. No.	Product Name	Chemical Structure

HY-W653944

Epalrestat-d5
Epalrestat-d₅ is deuterium labeled Epalrestat. Epalrestat is an orally active aldose reductase inhibitor that acts on diabetic neuropathy .

HY-B1392S

Esmolol-d7 hydrochloride

Esmolol-d₇ hydrochloride is the deuterium labeled Esmolol hydrochloride (HY-B1392). Esmolol hydrochloride is an ultra-short-acting cardioselective β1-adrenergic blocker. Esmolol hydrochloride exerts its antiarrhythmic effect by activating Neurokinin 1 Receptorinhibiting (aldose reductase) and the production of advanced glycation end products and promoting fibroblast migration. Esmolol hydrochloride can be used to study cardiac diseases such as arrhythmias and diabetic foot ulcers .

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