Minalrestat
Minalrestat (ARI-509) is a potent and orally active aldose reductase inhibitor. Minalrestat can be used in the research of diabetes.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 129688-50-2
- 分子式: C19H11BrF2N2O4
- 分子量:449.20
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Minalrestat (100 μM) decreased intracellular sorbitol without affecting intracellular glucose in primary cultured rat mesangial cells[3].
Minalrestat (100 μM, 48 h) causes accumulation of PKC-α and -β2 in primary cultured rat mesangial cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Primary cultured rat mesangial cells
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Concentration:100 μM
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Incubation Time:48 h
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Result:Increased accumulation of PKC-α and -β2.
Minalrestat (Oral gavage, 10 mg/kg) restores the reduced number of leukocytes adhered and migrated leukocytes in postcapillary venules in diabetic rats[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Alloxan (40 mg/kg i.v.)-induced diabetic rats[1]
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Dosage:10 mg/kg/day
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Administration:Oral gavage, for 30 days.
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Result:Restored the decreased microvascular reactivity.
化学情報
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CAS 番号 129688-50-2
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分子量 449.20
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分子式 C19H11BrF2N2O4
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SMILES
O=C(N1CC2=C(C=C(Br)C=C2)F)C3(CC(NC3=O)=O)C4=C(C=CC(F)=C4)C1=O
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別名
ARI-509; WAY-ARI 509
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Akamine EH, et al. Minalrestat, an aldose reductase inhibitor, corrects the impaired microvascular reactivity in diabetes. J Pharmacol Exp Ther. 2003 Mar;304(3):1236-42. [Content Brief]
[2]. Cruz JW, et al. Minalrestat and leukocyte migration in diabetes mellitus. Diabetes Metab Res Rev. 2003 May-Jun;19(3):223-31. [Content Brief]
[3]. Kapor-Drezgic J, et al. Effect of high glucose on mesangial cell protein kinase C-delta and -epsilon is polyol pathway-dependent. J Am Soc Nephrol. 1999 Jun;10(6):1193-203. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
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