ALR2/α-GLY-IN-1 

ALR2/α-GLY-IN-1 is a potent dual-target inhibitor that targets aldose reductase ALR2 and α-glucosidase (IC₅₀ values are 0.72 μM and 0.82 μM, respectively; K_i values are 1.67 μM and 1.37 μM, respectively). ALR2/α-GLY-IN-1 also acts as a DNA binder, which stably interacts with calf thymus double-stranded DNA through non-covalent interactions such as groove-binding mode and water-bridged hydrogen bonds. ALR2/α-GLY-IN-1 can be used in studies related to diabetes and its complications^[1].

ALR2/α-GLY-IN-1 (compound 3d) (10^-4 M; 15 min at ambient temperature for DPV analysis), interacts favorably with calf thymus double-stranded DNA ct-dsDNA via a minor groove-binding mechanism, with a binding constant of 8.6 × 10² M^-1, and the interaction can be detected electrochemically with a LOD of 0.099 ppm and LOQ of 0.327 ppm in the ct-dsDNA concentration range of 0.348 to 0.739 ppm^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

539.40

C₂₄H₁₉BrN₄O₄S

NC1=C(C(C2=CC=CC=C2C1=O)=O)N3C(C4=CC=C(C=C4)Br)=CS/C3=N\C(N5CCOCC5)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Efeoglu C, et al. 1,4-Naphthoquinone thiazole urea hybrids bearing morpholine/piperazine: synthesis, crystal structure, aldose reductase and α-glycosidase enzyme inhibition, molecular docking, and electrochemical interaction with dsDNA. Bioorg Med Chem Lett. Published online September 26, 2025.  [Content Brief]