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Cat. No.: HY-181519

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ALR2/α-GLY-IN-1

ALR2/α-GLY-IN-1 is a potent dual-target inhibitor that targets aldose reductase ALR2 and α-glucosidase (IC₅₀ values are 0.72 μM and 0.82 μM, respectively; K_i values are 1.67 μM and 1.37 μM, respectively). ALR2/α-GLY-IN-1 also acts as a DNA binder, which stably interacts with calf thymus double-stranded DNA through non-covalent interactions such as groove-binding mode and water-bridged hydrogen bonds. ALR2/α-GLY-IN-1 can be used in studies related to diabetes and its complications.

For research use only. We do not sell to patients.

Formula: C₂₄H₁₉BrN₄O₄S
Molecular Weight:539.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

ALR2/α-GLY-IN-1 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

α‑glucosidase

In Vitro

ALR2/α-GLY-IN-1 (compound 3d) (10^-4 M; 15 min at ambient temperature for DPV analysis), interacts favorably with calf thymus double-stranded DNA ct-dsDNA via a minor groove-binding mechanism, with a binding constant of 8.6 × 10² M^-1, and the interaction can be detected electrochemically with a LOD of 0.099 ppm and LOQ of 0.327 ppm in the ct-dsDNA concentration range of 0.348 to 0.739 ppm^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 539.40
Formula C₂₄H₁₉BrN₄O₄S
SMILES

NC1=C(C(C2=CC=CC=C2C1=O)=O)N3C(C4=CC=C(C=C4)Br)=CS/C3=N\C(N5CCOCC5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Efeoglu C, et al. 1,4-Naphthoquinone thiazole urea hybrids bearing morpholine/piperazine: synthesis, crystal structure, aldose reductase and α-glycosidase enzyme inhibition, molecular docking, and electrochemical interaction with dsDNA. Bioorg Med Chem Lett. Published online September 26, 2025. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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