6,7-Dihydroxy-4-coumarinylacetic acid

Cat. No.: HY-D0064 Purity: 95.58%: Data Sheet
COA

SDS
Handling Instructions
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6,7-Dihydroxy-4-coumarinylacetic acid is a potent and selective inhibitor of ALR2. 6,7-Dihydroxy-4-coumarinylacetic acid inhibits ALR2, SDH andALR1 with IC₅₀s of 9.6, 288 and 66.3 μM, respectively. 6,7-Dihydroxy-4-coumarinylacetic acid clearly suppresses galactitol accumulation.

For research use only. We do not sell to patients.

6,7-Dihydroxy-4-coumarinylacetic acid Chemical Structure

CAS No. : 88404-14-2

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Based on 1 publication(s) in Google Scholar

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Purity & Documentation
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Description

Molecular Weight

236.18

Formula

C₁₁H₈O₆

CAS No.

88404-14-2

Appearance

Solid

Color

Light yellow to brown

SMILES

O=C(O)CC(C1=CC(O)=C(O)C=C1O2)=CC2=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (105.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.2341 mL	21.1703 mL	42.3406 mL
5 mM	0.8468 mL	4.2341 mL	8.4681 mL
10 mM	0.4234 mL	2.1170 mL	4.2341 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 95.58%

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Data Sheet (272 KB) SDS (394 KB)

COA (252 KB) HNMR (255 KB) RP-HPLC (260 KB) MS (68 KB)

Handling Instructions (2659 KB)

References

[1]. Kato A, et al. 6,7-Dihydroxy-4-phenylcoumarin as inhibitor of aldose reductase 2. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5630-3. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.2341 mL	21.1703 mL	42.3406 mL	105.8515 mL
	5 mM	0.8468 mL	4.2341 mL	8.4681 mL	21.1703 mL
	10 mM	0.4234 mL	2.1170 mL	4.2341 mL	10.5851 mL
	15 mM	0.2823 mL	1.4114 mL	2.8227 mL	7.0568 mL
	20 mM	0.2117 mL	1.0585 mL	2.1170 mL	5.2926 mL
	25 mM	0.1694 mL	0.8468 mL	1.6936 mL	4.2341 mL
	30 mM	0.1411 mL	0.7057 mL	1.4114 mL	3.5284 mL
	40 mM	0.1059 mL	0.5293 mL	1.0585 mL	2.6463 mL
	50 mM	0.0847 mL	0.4234 mL	0.8468 mL	2.1170 mL
	60 mM	0.0706 mL	0.3528 mL	0.7057 mL	1.7642 mL
	80 mM	0.0529 mL	0.2646 mL	0.5293 mL	1.3231 mL
	100 mM	0.0423 mL	0.2117 mL	0.4234 mL	1.0585 mL