1. Metabolic Enzyme/Protease
  2. Aldose Reductase
  3. Zenarestat

Zenarestat 

Cat. No.: HY-116239
Handling Instructions

Zenarestat is a potent and orally active aldose reductase inhibitor. Zenarestat improves diabetic peripheral neuropathy in Zucker diabetic fatty rats.

For research use only. We do not sell to patients.

Zenarestat Chemical Structure

Zenarestat Chemical Structure

CAS No. : 112733-06-9

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Description

Zenarestat is a potent and orally active aldose reductase inhibitor. Zenarestat improves diabetic peripheral neuropathy in Zucker diabetic fatty rats[1].

In Vivo

Zenarestat (3.2, 32 mg/kg; p.o.; daily for 8 weeks) inhibits nerve sorbitol accumulation in a dose-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Zucker diabetic fatty (ZFD) rats (type 2 diabetes models)[1]
Dosage: 3.2, 32 mg/kg
Administration: P.o.; daily for 8 weeks
Result: At 3.2 mg/kg, zenarestat had no significant effect on the delay in F-wave minimal latency (FML) and the slowing of motor nerve conduction velocity (MNCV), although the sorbitol accumulation in the sciatic nerve was partially inhibited in ZDF rats. At 32 mg/kg zenarestat treatment improved these nerve dysfunctions in ZDF rats, along with a reduction of nerve sorbitol accumulation almost to the level of lean rats.
Molecular Weight

441.64

Formula

C₁₇H₁₁BrClFN₂O₄

CAS No.
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Zenarestat
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