2. Metabolic Enzyme/Protease
  3. Aldose Reductase
  4. Lidorestat

Lidorestat  (Synonyms: IDD-676)

Cat. No.: HY-106198 Purity: 99.50%
COA Handling Instructions

Lidorestat (IDD-676) is a potent, selective and orally active aldose reductase inhibitor with an IC50 of 5 nM. Lidorestat can be used for chronic diabetes complications. Lidorestat also improves nerve conduction and reduces cataract formation.

For research use only. We do not sell to patients.

Lidorestat Chemical Structure

Lidorestat Chemical Structure

CAS No. : 245116-90-9

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 55 In-stock
Solid
5 mg USD 50 In-stock
10 mg USD 80 In-stock
50 mg USD 240 In-stock
100 mg USD 380 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Lidorestat (IDD-676) is a potent, selective and orally active aldose reductase inhibitor with an IC50 of 5 nM. Lidorestat can be used for chronic diabetes complications. Lidorestat also improves nerve conduction and reduces cataract formation[1][2][3].

IC50 & Target

IC50: 5 nM (Rldose reductase)[1]
In Vitro

From in vitro experiments, Lidorestat has a reported IC50 against recombinant human aldose reductase (/h/-ALR2) of 5 μM. Against recombinant human aldehyde reductase (/h/-ALR1), Lidorestat has a reported IC50 of 27,000 μM, yielding a selectivity of /h/-ALR1//h/-ALR2 of 5400:1[1][2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

Lidorestat (25 mg/kg/day; oral administration; twice daily; for 6 weeks; diabetic mice) treatment decreases fructose and reduces mortality in diabetic hAR-expressing mice. And Lidorestat does not affect weight[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Diabetic low-density lipoprotein (LDL) receptor-deficient [Ldlr(-/-)] mice[1]
Dosage: 25 mg/kg/day
Administration: Oral administration; twice daily; for 6 weeks
Result: Diabetic hAR-expressing mice had decreased fructose and reduced mortality.
Clinical Trial
Molecular Weight

376.35

Appearance

Solid

Formula

C18H11F3N2O2S
CAS No.
SMILES

OC(CN1C(C=CC=C2)=C2C(CC3=NC(C(F)=C(F)C=C4F)=C4S3)=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (132.86 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6571 mL 13.2855 mL 26.5710 mL
5 mM 0.5314 mL 2.6571 mL 5.3142 mL
10 mM 0.2657 mL 1.3286 mL 2.6571 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.53 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.56 mg/mL (1.49 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.56 mg/mL (1.49 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.50%

COA (246 KB) HNMR (217 KB) LCMS (138 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Lidorestat245116-90-9IDD-676IDD676IDD 676Aldose ReductaseAberrantmetabolismglucosediabeticcomplicationsnerveconductioncataractInhibitorinhibitorinhibit

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