1. Metabolic Enzyme/Protease
  2. Aldose Reductase
  3. Lidorestat

Lidorestat (Synonyms: IDD-676)

Cat. No.: HY-106198 Purity: 99.50%
Handling Instructions

Lidorestat (IDD-676) is a potent, selective and orally active aldose reductase inhibitor with an IC50 of 5 nM. Lidorestat can be used to treat chronic diabetes complications. Lidorestat also improves nerve conduction and reduces cataract formation.

For research use only. We do not sell to patients.

Lidorestat Chemical Structure

Lidorestat Chemical Structure

CAS No. : 245116-90-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 100 In-stock
Estimated Time of Arrival: December 31
25 mg USD 200 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Lidorestat (IDD-676) is a potent, selective and orally active aldose reductase inhibitor with an IC50 of 5 nM. Lidorestat can be used to treat chronic diabetes complications. Lidorestat also improves nerve conduction and reduces cataract formation[1][2][3].

IC50 & Target

IC50: 5 nM (Rldose reductase)[1]

In Vitro

From in vitro experiments, Lidorestat has a reported IC50 against recombinant human aldose reductase (/h/-ALR2) of 5 μM. Against recombinant human aldehyde reductase (/h/-ALR1), Lidorestat has a reported IC50 of 27,000 μM, yielding a selectivity of /h/-ALR1//h/-ALR2 of 5400:1[1][2].

In Vivo

Lidorestat (25 mg/kg/day; oral administration; twice daily; for 6 weeks; diabetic mice) treatment decreases fructose and reduces mortality in diabetic hAR-expressing mice. And Lidorestat does not affect weight[1].

Animal Model: Diabetic low-density lipoprotein (LDL) receptor-deficient [Ldlr(-/-)] mice[1]
Dosage: 25 mg/kg/day
Administration: Oral administration; twice daily; for 6 weeks
Result: Diabetic hAR-expressing mice had decreased fructose and reduced mortality.
Molecular Weight

376.35

Formula

C₁₈H₁₁F₃N₂O₂S

CAS No.

245116-90-9

SMILES

OC(CN1C(C=CC=C2)=C2C(CC3=NC(C(F)=C(F)C=C4F)=C4S3)=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
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Keywords:

LidorestatIDD-676IDD676IDD 676Aldose ReductaseAberrantmetabolismglucosediabeticcomplicationsnerveconductioncataractInhibitorinhibitorinhibit

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Lidorestat
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HY-106198
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