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Results for "

rat liver microsome

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Acetyl-CoA Carboxylase (1) Acyltransferase (10) Adenosine Receptor (1) Adrenergic Receptor (1) Akt (1) Aldehyde Dehydrogenase (ALDH) (1) Amine N-methyltransferase (1) Aminopeptidase (1) Anaplastic lymphoma kinase (ALK) (1) Angiotensin Receptor (1) Apoptosis (6) Autophagy (2) Bacterial (2) Bcl-2 Family (2) Biochemical Assay Reagents (2) c-Met/HGFR (1) Calcium Channel (2) Cannabinoid Receptor (2) Casein Kinase (1) CD38 (1) CDK (1) Chloride Channel (1) COX (1) CXCR (1) Cytochrome P450 (8) Deubiquitinase (1) Dopamine Receptor (4) Drug Derivative (1) Drug Intermediate (1) Drug Metabolite (4) DUBTACs (1) Endogenous Metabolite (9) Environmental Pollutants (3) ERK (7) FAAH (2) Factor Xa (1) Factor XI (1) GABA Receptor (1) GnRH Receptor (1) Histamine Receptor (1) Histone Methyltransferase (1) IKZF Family (1) Interleukin Related (5) Isotope-Labeled Compounds (4) Kallikrein (1) Leukotriene Receptor (1) Lipocalin Family (1) Lipoxygenase (1) LPL Receptor (1) MAP3K (1) MDM-2/p53 (2) METTL3 (1) mGluR (1) Mitophagy (2) MMP (1) Molecular Glues (2) Monoamine Oxidase (2) mTOR (1) NF-κB (2) NO Synthase (3) P2X Receptor (2) Parasite (1) PARP (2) PGE synthase (1) Phosphatase (2) Phosphodiesterase (PDE) (5) Phytohormone (1) PI3K (1) Piezo Channel (1) Platelet-activating Factor Receptor (PAFR) (1) Pregnane X Receptor (PXR) (1) Progesterone Receptor (1) Prostaglandin Receptor (3) PROTACs (1) PTHR (1) Reactive Oxygen Species (ROS) (4) Reference Standards (3) Sigma Receptor (1) Sodium Channel (2) Somatostatin Receptor (1) STAT (1) Survivin (2) TGF-β Receptor (1) Thrombin (1) TNF Receptor (2) TRP Channel (1) UGT (3)
By Research Areas:	Cancer (20) Cardiovascular Disease (11) Endocrinology (2) Infection (13) Inflammation/Immunology (25) Metabolic Disease (22) Neurological Disease (21)
Click Chemistry:	Alkynes (1)

107

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Targets Recommended: LXR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10864

URB-597 5 Publications Verification KDS-4103	FAAH Autophagy Mitophagy	Neurological Disease
URB-597 (KDS-4103) is an orally bioavailable and selective FAAH inhibitor. URB-597 inhibits FAAH activity with an IC₅₀s of approximately 5 nM in rat brain membranes, 0.5 nM in intact rat neurons, 3 nM in human liver microsomes. Antidepressant-like effects. Analgesic activity .

HY-Y0262

Oxalic acid, 99% 1 Publications Verification Ethanedioic acid	Environmental Pollutants Endogenous Metabolite	Infection Inflammation/Immunology
Oxalic acid, 99% (Ethanedioic acid) is a dicarboxylic acid found in a wide variety of plants. Oxalic acid, 99% shows antioxidant acyivity and suppresses lipid peroxidation. Oxalic acid, 99% is a pathogenicity factor for sclerotinia sclerotiorum, and suppresses the oxidative burst of the host plant. Oxalic acid, 99% exerts acaricidal activity. Oxalic acid can be used for the researches of sclerotinia disease, varroatosis and inflammatory diseases .

HY-150508

MK-0159 1 Publications Verification	CD38	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
MK-0159 is an orally active, potent and selective CD38 inhibitor, with IC₅₀ values of 22, 3, and 70 nM for human, mouse and rat CD38, respectively. MK-0159 also shows good microsomal stability for human and rodent liver microsomes. MK-0159 increases NAD ⁺ (nicotinamide adenine dinucleotide) and reduces ADPR (adenosine diphosphate ribose) in whole blood and heart .

HY-B1311

Proadifen hydrochloride 1 Publications Verification SKF-525A; U-5446; RP-5171	Cytochrome P450 Monoamine Oxidase Bcl-2 Family Survivin PARP	Neurological Disease Inflammation/Immunology Cancer
Proadifen (SKF-525A) hydrochloride is a non-competitive Cytochrome P450 inhibitor with an IC₅₀ value of 19 μM. Proadifen hydrochloride reduces monoamine oxidase A (MAO-A) activity and reverses the antidepressantlike behavioral effect of Imipramine (HY-B1490A) and Desipramine (HY-B1272A) in rats. Proadifen hydrochloride also reduces N, N-dimethyltryptamine (DMT) metabolism in liver microsomes and inhibits N-demethylationand Acridone (HY-W007771) formation. Proadifen hydrochloride augments Lipopolysaccharide (LPS) (HY-D1056)-induced fever and exacerbates Prostaglandin E2 (PGE2) (HY-101952) levels in the rat. Proadifen hydrochloride is promising for research of metabolism-related deseases, ovarian carcinoma, inflammation and dopamine neurons-related deseases .

HY-W010981

Acetyl tributyl citrate 1 Publications Verification Tributyl O-acetylcitrate; ATBC	Environmental Pollutants Biochemical Assay Reagents	Others
Acetyl tributyl citrate (Tributyl O-acetylcitrate) is a pharmaceutical excipient and biodegradable hydrophobic plasticizer. Acetyl tributyl citrate can be used in cosmetics, food packaging, and as a flavoring substance for food .

HY-100634

4-Hydroxypropranolol hydrochloride (±)-4-hydroxy Propranolol hydrochloride	Adrenergic Receptor	Cardiovascular Disease
4-Hydroxypropranolol hydrochloride is a non-cardiac selective β-adrenergic receptor antagonist and a metabolite produced after oral administration of Propranolol (HY-B0573B). 4-Hydroxypropranolol hydrochloride also acts as a membrane stabilizer and possesses intrinsic sympathomimetic inhibitory activity. 4-Hydroxypropranolol hydrochloride blocks β-adrenergic receptors to antagonize the effects of catecholamines, acts as a partial β-adrenergic receptor agonist, and induces membrane stabilization. 4-Hydroxypropranolol hydrochloride alters heart rate, left ventricular contractility, and atrioventricular conduction time. 4-Hydroxypropranolol hydrochloride can be used in research related to cardiovascular and cerebrovascular diseases .

HY-145628

CM398	Sigma Receptor	Neurological Disease Inflammation/Immunology
CM398 is a highly selective, orally active Sigma-2 receptor ligand with a K_i value of 0.43 nM. CM398 ameliorates age-related macular degeneration. CM398 exerts analgesic effects on visceral pain, inflammatory pain and neuropathic pain. CM398 can be used in research related to age-related macular degeneration, neuropathic pain and inflammatory pain .

HY-124098

Lignocaine N-oxide Lidocaine N-oxide	Drug Metabolite	Others
Lignocaine N-oxide (Lidocaine N-oxide) is a compound derived from the metabolism of lidocaine. Lidocaine can be metabolized to its N-oxide in rat liver microsomes.

HY-153508

ANO1-IN-4	Chloride Channel	Others
ANO1-IN-4 (Compound 10bm) is a reversible inhibitor for calcium-activated chloride channel transmembrane protein 16A (TMEM16A, also known as ANO1) with an IC₅₀ of 0.030 µM. ANO1-IN-4 exhibits good metabolic stability in rat liver microsomes. ANO1-IN-4 inhibits spontaneous contraction in mouse isolated ileum .

HY-117290

BMS-962212	Factor Xa	Cardiovascular Disease
BMS-962212 is a factor XIa (FXIa) inhibitor with a K_i of 0.7 nM against human FXIa and a K_i of 3 nM against rabbit FXIa. BMS-962212 blocks thrombosis while preserving normal hemostatic function. BMS-962212 is applicable to thrombosis-related research .

HY-N3807

Enniatin B1 1 Publications Verification	Acyltransferase ERK NF-κB	Infection Cardiovascular Disease Cancer
Enniatin B1 is a Fusarium mycotoxin. Enniatin B1 inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC₅₀ of 73 μM in an enzyme assay using rat liver microsomes . Enniatin B1 crosss the blood-brain barrier . Enniatin B1 decreases the activation of ERK (p44/p42). Enniatin B1 inhibits moderately TNF-α-induced NF-κB activation .

HY-N4031

Humantenine	Anaplastic lymphoma kinase (ALK) METTL3	Inflammation/Immunology
Humantenine is a highly toxic indole alkaloid from Gelsemium elegans (Gardn. & Champ.) Benth. that binds to RNA m6A modification regulatory proteins (ALKBH5, METTL). Humantenine stably binds via hydrogen bonding and hydrophobic interactions and disrupts the m6A methylation level of target genes, thereby impairing the expression of intestinal epithelial cell tight junction and cytoskeleton-related genes, causing intestinal barrier dysfunction and significant intestinal cytotoxicity. The intraperitoneal injection LD₅₀ values of Humantenine are <1 mg/kg in mice, 1.2 mg/kg in male rats and 1.5 mg/kg in female rats, respectively. Species differences exist in the metabolism of Humantenine in human, porcine, goat and rat liver microsomes, and demethylation, dehydrogenation and oxidation occur in liver microsomes .

HY-N3806

Enniatin B	Acyltransferase ERK	Infection Cardiovascular Disease Cancer
Enniatin B is a Fusarium mycotoxin. Enniatin B inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC₅₀ of 113 μM in an enzyme assay using rat liver microsomes . Enniatins B decreases the activation of ERK (p44/p42) .

HY-152118

CYP1B1-IN-4	Cytochrome P450	Cancer
CYP1B1-IN-4 is a 2,4-diarylthiazole compound with selectively CYP1B1 inhibition (IC₅₀=0.2 nM). CYP1B1-IN-4 has little cytotoxicity and high stability in both human and rat liver microsomes .

HY-128268

PFK-IN-1	Parasite	Infection
PFK-IN-1 (compound 1) is a phosphofructokinase (PFK) inhibitor, with IC₅₀ values of 0.41 and 0.23 μM against T.brucei and T.cruzi PFK, respectively, and an ED₅₀ of 15.18 μg/mL for T.brucei. The half-lives of PFK-IN-1 in rat and mouse liver microsomes are 9.7 and 408 minutes, respectively .

HY-N4071

6"-O-Acetyldaidzin	Others	Others
6"-O-Acetyldaidzin is an isoflavone glycoside isolated from soybeans. 6"-O-Acetyldaidzin significantly inhibits lipid peroxidation in rat liver microsome with an IC₅₀ of 8.2 μM .

HY-N4070

6"-O-Acetylgenistin	Others	Others
6"-O-Acetylgenistin is an isoflavone glycoside isolated from soybeans. 6"-O-Acetylgenistin significantly inhibits lipid peroxidation in rat liver microsome with an IC₅₀ of 10.6 μM .

HY-151229

S-Methyl-N,N-diethylthiolcarbamate DETC-Me; DDTC-Me; Diethyldithiocarbamic acid methyl ester	Aldehyde Dehydrogenase (ALDH)	Metabolic Disease
S-Methyl-N,N-diethylthiolcarbamate (DETC-Me; DDTC-Me) is the active metabolite of the aldehyde dehydrogenase inhibitor disulfiram (HY-B0240). It is produced by the methylation of the disulfiram metabolite diethyldithiocarbamate in mouse liver microsomes. S-Methyl-N,N-diethylthiolcarbamate (DETC-Me; DDTC-Me) inhibits rat liver low Km aldehyde dehydrogenase (ALDH) (ID50=15.5 mg/kg). When administered at a dose of 20.6 mg/kg, it decreases mean arterial pressure (MAP) and increases heart rate in rats during ethanol stimulation.

HY-76667

3-(Boc-amino)propyl bromide	MDM-2/p53 Biochemical Assay Reagents Drug Intermediate	Others
3-(Boc-amino) propyl bromide is an alkylating reagent used for the N-alkylation of benzopyranotriazolopyrimidine-based MDM2-p53 protein-protein inhibitor 4 to prepare Compound 13 .

HY-173084

BRD6257	Phosphatase MDM-2/p53	Cancer
BRD6257 is an orally active inhibitor for protein phosphatase, Mg2+/Mn2+ dependent 1D PPM1D with an IC₅₀ of 5 nM. BRD6257 activates p53 signaling pathway with an EC₅₀ of 51 nM, increases the p21 expression, inhibits the proliferation of cancer cell MOLM13 (IC₅₀=2.8 μM). BRD6257 exhibits good metabolic stability in human and rat liver microsomes .

HY-170788

PDE7A-IN-1	Phosphodiesterase (PDE)	Metabolic Disease
PDE7A-IN-1 is an orally active and selective PDE7A inhibitor with an IC₅₀ of 0.0037 μM against PDE7A. PDE7A-IN-1 shows excellent isozyme selectivity over PDE7B. PDE7A-IN-1 elevates intracellular cAMP levels, suppresses ECR5 enhancer activity and reduces sclerostin expression. PDE7A-IN-1 significantly increases bone mineral density in rats. PDE7A-IN-1 can be used for the study of osteoporosis .

HY-B1341

Norethynodrel Enidrel; SC-4642; NSC 15432	Endogenous Metabolite Progesterone Receptor	Cancer
Norethynodrel (Enidrel; SC-4642) is an orally active progestogen analog that reduces estrogen-like effects and enhances progestogen-like responses in endometrial stromal cells. Norethynodrel also promotes cell maturation and predecidual cell formation by inducing organelle hyperplasia and glycogen accumulation. Norethynodrel competitively inhibits drug-metabolizing enzymes in rat liver microsomes, thereby prolonging Pentobarbital sleep time, while exhibiting multiple effects including reduced body weight gain, attenuated heart rate elevation and ovulation inhibition. In mouse models, Norethynodrel significantly increases the incidence of mammary adenocarcinoma, cervical cancer and pituitary tumors. Norethynodrel can be used for mechanism research on related diseases such as mammary adenocarcinoma, cervical cancer, ovarian tubular adenoma and pituitary adenoma .

HY-W003371

CGP 44 645	Drug Metabolite	Others
CGP 44 645 is the methanol metabolite of Letrozole (HY-14248) and is a molecular indicator for evaluating its metabolic kinetics in microsomes in vitro. Levels of CGP 44 645 in rat liver microsomes may be sex-specific .

HY-N8331

Terpendole I	Endogenous Metabolite Acyltransferase	Metabolic Disease
Terpendole I is a fungal indole diterpenoid and an ACAT inhibitor (IC₅₀ = 145 µM). Terpendole I can be used in studies related to lipid metabolism .

HY-169402A

PDE1-IN-9 hydrochloride	Phosphodiesterase (PDE) NO Synthase Reactive Oxygen Species (ROS) Interleukin Related	Inflammation/Immunology
PDE1-IN-9 (Compound 7a) hydrochloride is a selective inhibitor for phosphodiesterase 1 (PDE1), that inhibits PDE1C with an IC₅₀ of 11 nM. PDE1-IN-9 hydrochloride reduces mRNA expression of IL-1β, IL-6, TNF-α and iNOS, inhibits the production of nitric oxide (NO) and reactive oxygen species (ROS). PDE1-IN-9 hydrochloride exhibits good metabolic stability in rat liver microsomes .

HY-Y0262A

Oxalic acid diammonium monohydrate 1 Publications Verification Ethanedioic acid diammonium monohydrate	Environmental Pollutants Endogenous Metabolite	Infection Inflammation/Immunology
Oxalic acid (Ethanedioic acid) diammonium monohydrate is a dicarboxylic acid found in a wide variety of plants. Oxalic acid diammonium monohydrate shows antioxidant acyivity and suppresses lipid peroxidation. Oxalic acid diammonium monohydrate is a pathogenicity factor for sclerotinia sclerotiorum, and suppresses the oxidative burst of the host plant. Oxalic acid diammonium monohydrate exerts acaricidal activity. Oxalic acid can be used for the researches of sclerotinia disease varroatosis and inflammatory diseases .

HY-12835

S1P1 agonist III	LPL Receptor	Inflammation/Immunology
S1P1 agonist III is an orally active hS1P1 agonist with an EC₅₀ value of 18 nM. S1P1 agonist III shows limited activity against hS1P3. S1P1 agonist III can be used in the research of multiple sclerosis .

HY-N6702

Enniatin A	Acyltransferase	Infection Cardiovascular Disease
Enniatin A is a Fusarium mycotoxin. Enniatin A inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC₅₀ of 22 μM in an enzyme assay using rat liver microsomes .

HY-129344

CL 277082	Acyltransferase	Metabolic Disease
CL 277082 is a potent and selective acyl CoA:cholesterol acyltransferase (ACAT) inhibitor in microsomes. CL 277082 inhibits ACAT with IC₅₀ values of 0.14 μM for intestinal mucosal microsomes, 0.74 μM for liver, and 1.18 μM for rat adrenal. CL 277082 is a ACAT-catalyzed cholesterol esterification and cholesterol absorption inhibitor .

HY-130238

(±)8-HDHA (±)8-HDoHE; 8-hydroxy Docosahexaenoic acid; (±)8-HDoHE	Endogenous Metabolite	Metabolic Disease
(±)8-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. (±)8-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.

HY-148868A

Akt1&PKA-IN-2	Akt CDK	Cancer
Akt1&PKA-IN-2 (Compound R-29) is a AKT1 and PKA inhibitor with selectivity for CDK2, with IC₅₀ values of 0.007 and 0.01 μM, respectively. Akt1&PKA-IN-2 is applicable for cancer research .

HY-130288

(±)13-HDHA (±)13-HDoHE; 13-hydroxy Docosahexaenoic acid; (±)13-HDoHE	Lipoxygenase	Inflammation/Immunology
(±)13-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. Fresh water hydra is shown to metabolize DHA to 13(R)-HDHA, presumably via the 11R-lipoxygenase activity. (±)13-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.

HY-107534

AG-045572	GnRH Receptor	Endocrinology
AG-045572 is a GnRH receptor antagonist with K_is of 6.0 nM and 3.8 nM for human and rat GnRH receptor, respectively. AG-045572 is metabolized by CYP3A and ressuppresses testosterone .

HY-150519

FXIa/Plasma kallikrein-IN-1	Factor XI Kallikrein	Cardiovascular Disease
FXIa/Plasma kallikrein-IN-1 is an inhibitor of coagulation factor XIa (FXIa) and plasma kallikrein with K_i values of 187.70 nM and 151.6 nM, respectively. FXIa/Plasma kallikrein-IN-1 can be used in the research of thromboembolic diseases .

HY-N9515

Diallyl tetrasulfide	Apoptosis Reactive Oxygen Species (ROS)	Neurological Disease Metabolic Disease
Diallyl tetrasulfide is an orally active diallyl tetrasulfide. Diallyl tetrasulfide ameliorates cadmium-induced changes in acetylcholinesterase and adenosine triphosphatase activities as well as oxidative stress injury in the brain of rats . Diallyl tetrasulfide inhibits lipid peroxidation in rat liver microsomes . Diallyl tetrasulfide ameliorates cadmium-induced oxidative liver injury in rats . Diallyl tetrasulfide protects cells against cadmium-induced loss of cell viability, reduces apoptosis rate and ROS production. Diallyl tetrasulfide is applicable to research related to cadmium-induced neurotoxicity and cadmium-induced oxidative liver injury .

HY-172147

SSTR4 agonist 5	Somatostatin Receptor	Neurological Disease
SSTR4 agonist 5 (Compound 5) is the orally active agonist for somatostatin receptor 4 (SSTR4) with an EC₅₀ of 0.228 nM. SSTR4 agonist 5 exhibits good stability in human/rat liver microsomes. SSTR4 agonist 5 inhibits mechanical hyperalgesia in rat models .

HY-10864R

URB-597 (Standard) KDS-4103 (Standard)	FAAH Autophagy Mitophagy Reference Standards	Neurological Disease
URB-597 (Standard) is the analytical standard of URB-597. This product is intended for research and analytical applications. URB-597 (KDS-4103) is an orally bioavailable and selective FAAH inhibitor. URB-597 inhibits FAAH activity with an IC50s of approximately 5 nM in rat brain membranes, 0.5 nM in intact rat neurons, 3 nM in human liver microsomes. Antidepressant-like effects. Analgesic activity .

HY-146410

AT2R antagonist 1	Angiotensin Receptor	Others
AT2R antagonist 1 (compound 21) is a potent and high selective AT2R (angiotensin II AT2 receptor) ligand. AT2R antagonist 1 exhibits a fair AT2R affinity, with a K_i of 29 nM. AT2R antagonist 1 also inhibits common agent-metabolizing CYP enzymes. AT2R antagonist 1 shows high stability in human, rat and mouse liver microsomes .

HY-B0822S1

Fipronil-13C6	GABA Receptor Cytochrome P450	Inflammation/Immunology
Fipronil- ¹³C₆ is the ¹³C-labeled Fipronil. Fipronil is an insecticide that acts as a selective antagonist of insect GABA receptors (IC50s = 30 nM and 1,600 nM for cockroach and rat receptors, respectively). Fipronil also inhibits desensitizing and non-desensitizing glutamate-induced chloride currents in cockroach neurons (IC50s = 800 nM and 10 nM, respectively). Fipronil induces activity of the cytochrome P450 (CYP) isoforms CYP1A1/2, CYP2B1/2, and CYP3A1/2 in isolated rat liver microsomes.

HY-169332

Piezo1 agonist 1-d2	Piezo Channel ERK	Metabolic Disease
Piezo1 agonist 1-d2 is a Piezo1 agonist and osteogenesis promoter with an EC₅₀ of 2.21 μM. Piezo1 agonist 1-d2 activates Piezo1 and induces calcium ion influx in mesenchymal stem cells. Piezo1 agonist 1-d2 activates the Erk signaling pathway and promotes osteogenesis of mesenchymal stem cells. Piezo1 agonist 1-d2 alleviates disuse osteoporosis in a hindlimb unloading rat model. Piezo1 agonist 1-d2 can be used for research on osteoporosis .

HY-118048

NAV 26	Sodium Channel	Neurological Disease
NAV 26 (Compound 26) is a selective Na_V1.7 inhibitor with an IC₅₀ of 0.37 μM. NAV 26 is applicable for pain-related research .

HY-W741611

Dehydro Warfarin NSC 289346	Drug Metabolite	Metabolic Disease
Dehydro warfarin is a metabolite of (±)-warfarin. It is formed from (±)-warfarin by rat liver microsomes.

HY-182255

ED-594	Endogenous Metabolite	Others
ED-594 is the glucuronide form of NB-506. ED-594 is one of the major metabolites of NB-506 in rat bile, mouse liver microsomes, rat liver microsomes and human liver microsomes .

HY-175078

(±)19(20)-DiHDPA 19(20)-DHDP; (±)19,20-DiHDoPE	Endogenous Metabolite	Others
(±)19(20)-DiHDPA is one of the major metabolites produces when docosahexaenoic acid is incubated with NADPH-supplemented rat liver microsomes .

HY-B1311R

Proadifen hydrochloride (Standard) SKF-525A (Standard); U-5446 (Standard); RP-5171 (Standard)	Reference Standards Cytochrome P450 Monoamine Oxidase Bcl-2 Family Survivin PARP	Neurological Disease Inflammation/Immunology Cancer
Proadifen (hydrochloride) (Standard) is the analytical standard of Proadifen (hydrochloride). This product is intended for research and analytical applications. Proadifen (SKF-525A) hydrochloride is a non-competitive Cytochrome P450 inhibitor with an IC50 value of 19 μM. Proadifen hydrochloride reduces monoamine oxidase A (MAO-A) activity and reverses the antidepressantlike behavioral effect of Imipramine (HY-B1490A) and Desipramine (HY-B1272A) in rats. Proadifen hydrochloride also reduces N, N-dimethyltryptamine (DMT) metabolism in liver microsomes and inhibits N-demethylationand Acridone (HY-W007771) formation. Proadifen hydrochloride augments Lipopolysaccharide (LPS) (HY-D1056)-induced fever and exacerbates Prostaglandin E2 (PGE2) (HY-101952) levels in the rat. Proadifen hydrochloride is promising for research of metabolism-related deseases, ovarian carcinoma, inflammation and dopamine neurons-related deseases [4] .

HY-16442

S-3483	Phosphatase	Metabolic Disease
S-3483, a Chlorogenic acid (HY-N0055) derivative, is a reversible, linear competitive glucose-6-phosphatase (Glc-6-Pase) system inhibitor. S-3483 inhibits Glc-6-Pase with a K_i 129 nM in rat liver microsomes. S-3483 specifically inhibits Glc-6-P transporter of renal and liver microsomes .

HY-N15411

Helminthosporol	Acyltransferase Phytohormone	Metabolic Disease
Helminthosporol is a natural plant growth-regulator that can promote the growth of rice and lettuce seedlings. Helminthosporol can also inhibit the activity of acyl-CoA: cholesterol acyltransferase (ACAT) in rat liver microsomes and the synthesis of cholesterol esters in macrophages .

HY-125568

Pyridoxatin	MMP	Others
Pyridoxatin is a free radical scavenger of microbial origin. Pyridoxatin is isolated from a fungus culture identified as Acremonium sp. BX86. Pyridoxatin inhibits lipid peroxidation induced by free radicals in rat liver microsomes free from vitamin E .

HY-130287

(±)16-HDHA (±)16-HDoHE; 16-hydroxy Docosahexaenoic acid; (±)16-HDoHE	Endogenous Metabolite	Metabolic Disease
(±)16-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. (±)16-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.

HY-113777

22-HDHA 22-Hydroxy Docosahexaenoic acid; 22-OH DHA	Cytochrome P450	Metabolic Disease
22-HDHA (22-Hydroxy Docosahexaenoic acid) is an oxidation product of docosahexaenoic acid. In vitro, it is formed upon incubation of rat liver microsomes with DHA and NADPH and also by the human cytochrome P450 (CYP) isoform CYP4F3B in BTI-TN-5B1-4 microsomes. Serum levels of 22-HDHA increase following dietary DHA supplementation in humans.

Cat. No.	Product Name	Type

HY-Y0262A

Oxalic acid diammonium monohydrate

1 Publications Verification

Ethanedioic acid diammonium monohydrate

Biochemical Assay Reagents

Oxalic acid (Ethanedioic acid) diammonium monohydrate is a dicarboxylic acid found in a wide variety of plants.
Oxalic acid diammonium monohydrate shows antioxidant acyivity and suppresses lipid peroxidation.
Oxalic acid diammonium monohydrate is a pathogenicity factor for sclerotinia sclerotiorum, and suppresses the oxidative burst of the host plant. Oxalic acid diammonium monohydrate exerts acaricidal activity. Oxalic acid can be used for the researches of sclerotinia disease varroatosis and inflammatory diseases .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-Y0262

Oxalic acid, 99% 1 Publications Verification Ethanedioic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Endocrine diseases Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Endogenous Metabolite
Oxalic acid, 99% (Ethanedioic acid) is a dicarboxylic acid found in a wide variety of plants. Oxalic acid, 99% shows antioxidant acyivity and suppresses lipid peroxidation. Oxalic acid, 99% is a pathogenicity factor for sclerotinia sclerotiorum, and suppresses the oxidative burst of the host plant. Oxalic acid, 99% exerts acaricidal activity. Oxalic acid can be used for the researches of sclerotinia disease, varroatosis and inflammatory diseases .

HY-N3807

Enniatin B1 1 Publications Verification	Infection Cardiovascular Disease Alkaloids Microorganisms Classification of Application Fields Other Alkaloids Disease Research Fields Source Classification	Acyltransferase ERK NF-κB
Enniatin B1 is a Fusarium mycotoxin. Enniatin B1 inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC₅₀ of 73 μM in an enzyme assay using rat liver microsomes . Enniatin B1 crosss the blood-brain barrier . Enniatin B1 decreases the activation of ERK (p44/p42). Enniatin B1 inhibits moderately TNF-α-induced NF-κB activation .

HY-N4031

Humantenine	Alkaloids Structural Classification Classification of Application Fields Other Diseases Loganiaceae Plants Gelsemium eleganis (Gardn. et Champ.) Benth. Disease Research Fields Indole Alkaloids Source Classification	Anaplastic lymphoma kinase (ALK) METTL3
Humantenine is a highly toxic indole alkaloid from Gelsemium elegans (Gardn. & Champ.) Benth. that binds to RNA m6A modification regulatory proteins (ALKBH5, METTL). Humantenine stably binds via hydrogen bonding and hydrophobic interactions and disrupts the m6A methylation level of target genes, thereby impairing the expression of intestinal epithelial cell tight junction and cytoskeleton-related genes, causing intestinal barrier dysfunction and significant intestinal cytotoxicity. The intraperitoneal injection LD₅₀ values of Humantenine are <1 mg/kg in mice, 1.2 mg/kg in male rats and 1.5 mg/kg in female rats, respectively. Species differences exist in the metabolism of Humantenine in human, porcine, goat and rat liver microsomes, and demethylation, dehydrogenation and oxidation occur in liver microsomes .

HY-N3806

Enniatin B	Infection Cardiovascular Disease Alkaloids Microorganisms Classification of Application Fields Disease Research Fields Source Classification	Acyltransferase ERK
Enniatin B is a Fusarium mycotoxin. Enniatin B inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC₅₀ of 113 μM in an enzyme assay using rat liver microsomes . Enniatins B decreases the activation of ERK (p44/p42) .

HY-N4071

6"-O-Acetyldaidzin	Monophenols Flavonoids Classification of Application Fields Leguminosae Glycine max (L.) merr Other Diseases Phenols Plants Disease Research Fields Isoflavones Source Classification	Others
6"-O-Acetyldaidzin is an isoflavone glycoside isolated from soybeans. 6"-O-Acetyldaidzin significantly inhibits lipid peroxidation in rat liver microsome with an IC₅₀ of 8.2 μM .

HY-N4070

6"-O-Acetylgenistin	Flavonoids Classification of Application Fields Leguminosae Glycine max (L.) merr Other Diseases Phenols Polyphenols Plants Disease Research Fields Isoflavones Source Classification	Others
6"-O-Acetylgenistin is an isoflavone glycoside isolated from soybeans. 6"-O-Acetylgenistin significantly inhibits lipid peroxidation in rat liver microsome with an IC₅₀ of 10.6 μM .

HY-B1341

Norethynodrel Enidrel; SC-4642; NSC 15432	Structural Classification Classification of Application Fields Endogenous metabolite Disease Research Fields Endocrinology Steroids Source Classification	Endogenous Metabolite Progesterone Receptor
Norethynodrel (Enidrel; SC-4642) is an orally active progestogen analog that reduces estrogen-like effects and enhances progestogen-like responses in endometrial stromal cells. Norethynodrel also promotes cell maturation and predecidual cell formation by inducing organelle hyperplasia and glycogen accumulation. Norethynodrel competitively inhibits drug-metabolizing enzymes in rat liver microsomes, thereby prolonging Pentobarbital sleep time, while exhibiting multiple effects including reduced body weight gain, attenuated heart rate elevation and ovulation inhibition. In mouse models, Norethynodrel significantly increases the incidence of mammary adenocarcinoma, cervical cancer and pituitary tumors. Norethynodrel can be used for mechanism research on related diseases such as mammary adenocarcinoma, cervical cancer, ovarian tubular adenoma and pituitary adenoma .

HY-N8331

Terpendole I	Alkaloids Structural Classification Microorganisms Classification of Application Fields Terpenoids Diterpenoids Disease Research Fields Indole Alkaloids Source Classification Cancer	Endogenous Metabolite Acyltransferase
Terpendole I is a fungal indole diterpenoid and an ACAT inhibitor (IC₅₀ = 145 µM). Terpendole I can be used in studies related to lipid metabolism .

HY-N4267

Yangambin	Cardiovascular Disease Structural Classification other families Classification of Application Fields Lignans Phenylpropanoids Plants Disease Research Fields Source Classification	Calcium Channel Platelet-activating Factor Receptor (PAFR) UGT Leukotriene Receptor TNF Receptor PGE synthase Interleukin Related
Yangambin is a PAF receptor antagonist and UGT1A1/UGT1A3 inhibitor, with an IC₅₀ of 29.7 μM and a K_i of 17.1 μM against human UGT1A1, and an IC₅₀ of 56.5 μM and a K_i of 66.8 μM against human UGT1A3. Yangambin blocks PAF-mediated responses, inhibits LTB₄-mediated neutrophil infiltration, and suppresses inflammatory events and anaphylactic contraction. Yangambin acts as a central nervous system inhibitor to reduce spontaneous activity, and also exhibits analgesic, anticonvulsant, antileishmanial, vasodilatory and hypotensive effects. Yangambin blocks voltage-gated Ca ²⁺ channels, reduces the production of NO, TNF-α, IL-6 and PGE2 in cells, increases the production of IL-10, and exerts a protective effect against cardiovascular injury. Yangambin can be used in research related to allergies, cutaneous leishmaniasis, central nervous system diseases and cardiovascular diseases .

HY-N6702

Enniatin A	Cardiovascular Disease Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Source Classification	Acyltransferase
Enniatin A is a Fusarium mycotoxin. Enniatin A inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC₅₀ of 22 μM in an enzyme assay using rat liver microsomes .

HY-N9515

Diallyl tetrasulfide	Structural Classification Natural Products Allium sativum L. Plants Amaryllidaceae Source Classification	Apoptosis Reactive Oxygen Species (ROS)
Diallyl tetrasulfide is an orally active diallyl tetrasulfide. Diallyl tetrasulfide ameliorates cadmium-induced changes in acetylcholinesterase and adenosine triphosphatase activities as well as oxidative stress injury in the brain of rats . Diallyl tetrasulfide inhibits lipid peroxidation in rat liver microsomes . Diallyl tetrasulfide ameliorates cadmium-induced oxidative liver injury in rats . Diallyl tetrasulfide protects cells against cadmium-induced loss of cell viability, reduces apoptosis rate and ROS production. Diallyl tetrasulfide is applicable to research related to cadmium-induced neurotoxicity and cadmium-induced oxidative liver injury .

HY-N15411

Helminthosporol	Terpenoids Sesquiterpenes Millettia erythrocalyx Gagnep. Plants Compositae Source Classification	Acyltransferase Phytohormone
Helminthosporol is a natural plant growth-regulator that can promote the growth of rice and lettuce seedlings. Helminthosporol can also inhibit the activity of acyl-CoA: cholesterol acyltransferase (ACAT) in rat liver microsomes and the synthesis of cholesterol esters in macrophages .

HY-125568

Pyridoxatin	Alkaloids Microorganisms Classification of Application Fields Other Diseases Pyridine Alkaloids Disease Research Fields Source Classification	MMP
Pyridoxatin is a free radical scavenger of microbial origin. Pyridoxatin is isolated from a fungus culture identified as Acremonium sp. BX86. Pyridoxatin inhibits lipid peroxidation induced by free radicals in rat liver microsomes free from vitamin E .

HY-N6704

Enniatin A1	Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Antibacterial Disease Research Anticancer Disease Research Fields Cancer Source Classification	ERK Apoptosis
Enniatin A1 isolated from Fusarium mycotoxins is a cyclic hexadepsipeptide consisting of alternating D-α-hydroxyisovaleric acids and N-methyl-L-amino acids. Enniatin A1 possesses anticarcinogenic properties by induction of apoptosis and disruption of ERK signalling pathway. Enniatin A1 inhibits ACAT with an IC₅₀ of 49 μM in rat liver microsomes .

HY-N12571A

(E/Z)-3-Hydroxylicochalcone A	Structural Classification Leguminosae Glycyrrhiza inflata Batal. Phenols Polyphenols Plants Source Classification	Reactive Oxygen Species (ROS) Interleukin Related Prostaglandin Receptor
(E/Z)-3-Hydroxylicochalcone A (Compound 1) is a flavonoid found in licorice (Glycyrrhiza inflata and Glycyrrhiza uralensis), with antioxidant and anti-inflammatory activity. (E/Z)-3-Hydroxylicochalcone A inhibits lipid peroxidation in rat liver microsomes. (E/Z)-3-Hydroxylicochalcone A inhibits LPS (HY-D1056)-induced ROS, NO, IL-6, and PGE2 production .

HY-N17823

Plantagoside A	Plantaginaceae Structural Classification Phenols Polyphenols Plantago asiatica L. Plants Source Classification	Others
Plantagoside A (Compound 3) is a phenylethanoid glycoside found in Plantago asiatica. Plantagoside A has antioxidant activity and can inhibit lipid peroxidation in rat liver microsomes induced by ADP and NADPH with an IC₅₀ of 0.54 μM .

Cat. No.	Product Name	Chemical Structure

HY-B0822S1

Fipronil-13C6

Fipronil- ¹³C₆ is the ¹³C-labeled Fipronil. Fipronil is an insecticide that acts as a selective antagonist of insect GABA receptors (IC50s = 30 nM and 1,600 nM for cockroach and rat receptors, respectively). Fipronil also inhibits desensitizing and non-desensitizing glutamate-induced chloride currents in cockroach neurons (IC50s = 800 nM and 10 nM, respectively). Fipronil induces activity of the cytochrome P450 (CYP) isoforms CYP1A1/2, CYP2B1/2, and CYP3A1/2 in isolated rat liver microsomes.

HY-169332

Piezo1 agonist 1-d2

Piezo1 agonist 1-d2 is a Piezo1 agonist and osteogenesis promoter with an EC₅₀ of 2.21 μM. Piezo1 agonist 1-d2 activates Piezo1 and induces calcium ion influx in mesenchymal stem cells. Piezo1 agonist 1-d2 activates the Erk signaling pathway and promotes osteogenesis of mesenchymal stem cells. Piezo1 agonist 1-d2 alleviates disuse osteoporosis in a hindlimb unloading rat model. Piezo1 agonist 1-d2 can be used for research on osteoporosis .

HY-N6702S

Enniatin A-13C36
Enniatin A- ¹³C₃₆ is the ¹³C-labeled Enniatin A (HY-N6702). Enniatin A is a Fusarium mycotoxin. Enniatin A inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC₅₀ of 22 μM in an enzyme assay using rat liver microsomes .

HY-N3806S

Enniatin B-13C33
Enniatin B- ¹³C₃₃ is the ¹³C-labeled Enniatin B (HY-N3806). Enniatin B is a Fusarium mycotoxin. Enniatin B inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 113 μM in an enzyme assay using rat liver microsomes . Enniatins B decreases the activation of ERK (p44/p42) .

HY-N6704S

Enniatin A1-13C35

Enniatin A1- ¹³C₃₅ is the ¹³C-labeled Enniatin A1 (HY-N6704). Enniatin A1 isolated from Fusarium mycotoxins is a cyclic hexadepsipeptide consisting of alternating D-α-hydroxyisovaleric acids and N-methyl-L-amino acids. Enniatin A1 possesses anticarcinogenic properties by induction of apoptosis and disruption of ERK signalling pathway. Enniatin A1 inhibits ACAT with an IC50 of 49 μM in rat liver microsomes .

HY-N3807S

Enniatin B1-13C34

Enniatin B1- ¹³C₃₄ is the ¹³C-labeled Enniatin B1 (HY-N3807). Enniatin B1 is a Fusarium mycotoxin. Enniatin B1 inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC₅₀ of 73 μM in an enzyme assay using rat liver microsomes . Enniatin B1 crosss the blood-brain barrier . Enniatin B1 decreases the activation of ERK (p44/p42). Enniatin B1 inhibits moderately TNF-α-induced NF-κB activation .

Cat. No.	Product Name		Classification

HY-B1341

Norethynodrel Enidrel; SC-4642; NSC 15432		Alkynes
Norethynodrel (Enidrel; SC-4642) is an orally active progestogen analog that reduces estrogen-like effects and enhances progestogen-like responses in endometrial stromal cells. Norethynodrel also promotes cell maturation and predecidual cell formation by inducing organelle hyperplasia and glycogen accumulation. Norethynodrel competitively inhibits drug-metabolizing enzymes in rat liver microsomes, thereby prolonging Pentobarbital sleep time, while exhibiting multiple effects including reduced body weight gain, attenuated heart rate elevation and ovulation inhibition. In mouse models, Norethynodrel significantly increases the incidence of mammary adenocarcinoma, cervical cancer and pituitary tumors. Norethynodrel can be used for mechanism research on related diseases such as mammary adenocarcinoma, cervical cancer, ovarian tubular adenoma and pituitary adenoma .

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