NAV 26
Based on 1 Customer Validation
NAV 26 (Compound 26) is a selective NaV1.7 inhibitor with an IC50 of 0.37 μM. NAV 26 is applicable for pain-related research.
For research use only. We do not sell to patients.
- Purity: 99.79%
- CAS No.: 1198160-14-3
- Formula: C22H21F3N2O4
- Molecular Weight:434.41
-
Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
Membrane Transporter/Ion Channel Compound Library
HY-L011
-
Neuroprotective Compound Library
HY-L070
-
Sodium Channel Blocker Library
HY-L118
-
Heterocyclic Compound Library
HY-L138
-
Membrane Protein-targeted Compound Library
HY-L149
-
Membrane Receptor-targeted Compound Library
HY-L150
-
Highly Selective Inhibitors Library
HY-L158
-
Ion Channel Compound Library
HY-L166
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Bioactive Compound Library
HY-L001
-
High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
|
Nav1.7 0.37 μM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| CHO-K1 | IC50 |
>33 μM
Compound: 26B, enantiomer 2
|
Inhibition of human NaV1.2 alpha subunit expressed in CHOK1 cells at -65 mV holding potential by patch clamp electrophysiological assay
Inhibition of human NaV1.2 alpha subunit expressed in CHOK1 cells at -65 mV holding potential by patch clamp electrophysiological assay
|
[PMID: 22770500] |
| CHO-K1 | IC50 |
>33 μM
Compound: 26
|
Binding affinity to human ERG expressed in CHOK1 cells by IonWorks HT assay
Binding affinity to human ERG expressed in CHOK1 cells by IonWorks HT assay
|
[PMID: 22770500] |
| HEK293 | IC50 |
>33 μM
Compound: 26B, enantiomer 2
|
Inhibition of human NaV1.7 F1737A mutant expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assay
Inhibition of human NaV1.7 F1737A mutant expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assay
|
[PMID: 22770500] |
| HEK293 | IC50 |
1.6 μM
Compound: 26B, enantiomer 2
|
Inhibition of recombinant rat NaV1.7 alpha subunit expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assay
Inhibition of recombinant rat NaV1.7 alpha subunit expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assay
|
[PMID: 22770500] |
| HEK293 | IC50 |
3.8 μM
Compound: 26B, enantiomer 2
|
Inhibition of recombinant human NaV1.7 alpha subunit expressed in HEK293 cells at -90 mV holding potential by patch clamp electrophysiological assay
Inhibition of recombinant human NaV1.7 alpha subunit expressed in HEK293 cells at -90 mV holding potential by patch clamp electrophysiological assay
|
[PMID: 22770500] |
Chemical Information
-
CAS No. 1198160-14-3
-
Appearance Solid
-
Molecular Weight 434.41
-
Formula C22H21F3N2O4
-
Color White to off-white
-
SMILES
O=C1C2=CC=CC=C2C(N1C3CCOCC3)C(NCC4=CC=C(C=C4)OC(F)(F)F)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (287.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (274 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3020 mL | 11.5099 mL | 23.0197 mL | 57.5493 mL |
| 5 mM | 0.4604 mL | 2.3020 mL | 4.6039 mL | 11.5099 mL | |
| 10 mM | 0.2302 mL | 1.1510 mL | 2.3020 mL | 5.7549 mL | |
| 15 mM | 0.1535 mL | 0.7673 mL | 1.5346 mL | 3.8366 mL | |
| 20 mM | 0.1151 mL | 0.5755 mL | 1.1510 mL | 2.8775 mL | |
| 25 mM | 0.0921 mL | 0.4604 mL | 0.9208 mL | 2.3020 mL | |
| 30 mM | 0.0767 mL | 0.3837 mL | 0.7673 mL | 1.9183 mL | |
| 40 mM | 0.0575 mL | 0.2877 mL | 0.5755 mL | 1.4387 mL | |
| 50 mM | 0.0460 mL | 0.2302 mL | 0.4604 mL | 1.1510 mL | |
| 60 mM | 0.0384 mL | 0.1918 mL | 0.3837 mL | 0.9592 mL | |
| 80 mM | 0.0288 mL | 0.1439 mL | 0.2877 mL | 0.7194 mL | |
| 100 mM | 0.0230 mL | 0.1151 mL | 0.2302 mL | 0.5755 mL |
Powered by Bioz