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Cat. No.: HY-183776

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Dopamine D3 receptor agonist-2

Dopamine D3 receptor agonist-2 is a selective dopamine D3 receptor partial agonist with a K_i of 0.268 nM. Dopamine D3 receptor agonist-2 exhibits 29-fold selectivity over dopamine D2 receptor (K_i= 7.67nM).

For research use only. We do not sell to patients.

CAS No.: 1000031-37-7
Formula: C₂₁H₃₁Cl₂N₃O₂
Molecular Weight:428.40

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Please store the product under the recommended conditions in the Certificate of Analysis.

Dopamine D3 receptor agonist-2 Chemical Structure

CAS No.: 1000031-37-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

dopamine D_2L receptor

7.67 nM (Ki)

D₃ Receptor

0.268 nM (Ki)

D₁ Receptor

4700 nM (Ki)

D₄ Receptor

284 nM (Ki)

All Dopamine Receptor Isoforms :

In Vitro

Dopamine D3 receptor agonist-2 (compound 8) (0.01 nM-10 μM; 10 min) acts as an agonist at human D₂LR transiently expressed in HEK293T cells, with an efficacy of 85.6-95.4% relative to Dopamine (HY-B0451)^[1].
Dopamine D3 receptor agonist-2 (0.01 nM-10 μM; 10 min) acts as a partial agonist at human D₃R transiently expressed in HEK293T cells, with an efficacy of 64.6-79.5% relative to Dopamine (HY-B0451)^[1].
Dopamine D3 receptor agonist-2 binds to human D₁R, D₄R, and multiple serotonin receptors with lower affinity than for D₃R, including a high affinity for 5-HT_2B R (K_i = 1.14 nM) and ≥140-fold selectivity for D₃R over 5-HT_2A R^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1000031-37-7
Molecular Weight 428.40
Formula C₂₁H₃₁Cl₂N₃O₂
SMILES

ClC1=C(Cl)C(N2CCN(CC[C@H]3CC[C@H](NC(COC)=O)CC3)CC2)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Vogt CD, et al. Tailoring cariprazine for dual disorders via secondary pharmacophore optimization. Eur J Med Chem. 2026;307:118654. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Dopamine D3 receptor agonist-2

All Dopamine Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Dopamine D3 receptor agonist-2 Related Classifications

HY-183776 Related Classifications