(E/Z)-3-Hydroxylicochalcone A
(E/Z)-3-Hydroxylicochalcone A (Compound 1) is a flavonoid found in licorice (Glycyrrhiza inflata and
Glycyrrhiza uralensis), with antioxidant and anti-inflammatory activity. (E/Z)-3-Hydroxylicochalcone A inhibits lipid peroxidation in rat liver microsomes. (E/Z)-3-Hydroxylicochalcone A inhibits LPS (HY-D1056)-induced ROS, NO, IL-6, and PGE2 production.
For research use only. We do not sell to patients.
- CAS No.: 1083200-74-1
- Formula: C21H22O5
- Molecular Weight:354.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Glycyrrhiza uralensis), with antioxidant and anti-inflammatory activity. (E/Z)-3-Hydroxylicochalcone A inhibits lipid peroxidation in rat liver microsomes. (E/Z)-3-Hydroxylicochalcone A inhibits LPS (HY-D1056)-induced ROS, NO, IL-6, and PGE2 production[1].
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IL-6 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK-293T | GI |
11 %
Compound: 12; DTM
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Growth inhibition of human HEK293T cells at 10 uM after 24 hrs by MTS assay relative to control
Growth inhibition of human HEK293T cells at 10 uM after 24 hrs by MTS assay relative to control
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[PMID: 28522265] |
(E/Z)-3-Hydroxylicochalcone A (Compound DTM) inhibits lipid peroxidation in rat liver microsomes with an EC50 of 9.22 μM[1].
(E/Z)-3-Hydroxylicochalcone A (1-10 μM; 24 h) inhibits LPS (HY-D1056)-induced ROS production and NO, IL-6, and PGE2 levles in RAW 264.7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1083200-74-1
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Molecular Weight 354.40
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Formula C21H22O5
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SMILES
O=C(C1=CC=C(C=C1)O)/C=C/C2=C(OC)C(O)=C(O)C(C(C)(C)C=C)=C2
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(E/Z)-3-Hydroxylicochalcone A Related Classifications
Cat. No.: HY-N12571A
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- (E/Z)-3-Hydroxylicochalcone A
- 1083200-74-1
- Reactive Oxygen Species (ROS)
- Interleukin Related
- Prostaglandin Receptor
- Glycyrrhiza inflata
- anti-inflammatory activity
- reactive oxygen species
- rat liver microsomes
- interleukin-6
- macrophages
- Glycyrrhiza uralensis
- antioxidant activity
- lipid peroxidation
- nitric oxide
- Inhibitor
- inhibitor
- inhibit