(E/Z)-3-Hydroxylicochalcone A
(E/Z)-3-Hydroxylicochalcone A (Compound 1) is a flavonoid found in licorice (Glycyrrhiza inflata and
Glycyrrhiza uralensis), with antioxidant and anti-inflammatory activity. (E/Z)-3-Hydroxylicochalcone A inhibits lipid peroxidation in rat liver microsomes. (E/Z)-3-Hydroxylicochalcone A inhibits LPS (HY-D1056)-induced ROS, NO, IL-6, and PGE2 production.
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- CAS No.: 1083200-74-1
- Formule: C21H22O5
- Masse moléculaire:354.40
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
Glycyrrhiza uralensis), with antioxidant and anti-inflammatory activity. (E/Z)-3-Hydroxylicochalcone A inhibits lipid peroxidation in rat liver microsomes. (E/Z)-3-Hydroxylicochalcone A inhibits LPS (HY-D1056)-induced ROS, NO, IL-6, and PGE2 production[1].
IC50 & Target
[1]|
IL-6 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| HEK-293T | GI |
11 %
Compound: 12; DTM
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Growth inhibition of human HEK293T cells at 10 uM after 24 hrs by MTS assay relative to control
Growth inhibition of human HEK293T cells at 10 uM after 24 hrs by MTS assay relative to control
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[PMID: 28522265] |
In Vitro
(E/Z)-3-Hydroxylicochalcone A (Compound DTM) inhibits lipid peroxidation in rat liver microsomes with an EC50 of 9.22 μM[1].
(E/Z)-3-Hydroxylicochalcone A (1-10 μM; 24 h) inhibits LPS (HY-D1056)-induced ROS production and NO, IL-6, and PGE2 levles in RAW 264.7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1083200-74-1
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Masse moléculaire 354.40
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Formule C21H22O5
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SMILES
O=C(C1=CC=C(C=C1)O)/C=C/C2=C(OC)C(O)=C(O)C(C(C)(C)C=C)=C2
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(E/Z)-3-Hydroxylicochalcone A Related Classifications
HY-N12571A Related Classifications
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Keywords
- (E/Z)-3-Hydroxylicochalcone A
- 1083200-74-1
- Reactive Oxygen Species (ROS)
- Interleukin Related
- Prostaglandin Receptor
- IL
- Glycyrrhiza inflata
- anti-inflammatory activity
- reactive oxygen species
- rat liver microsomes
- interleukin-6
- macrophages
- Glycyrrhiza uralensis
- antioxidant activity
- lipid peroxidation
- nitric oxide
- Inhibitor
- inhibitor
- inhibit