2. SARS-CoV-2 3CLpro-IN-37

SARS-CoV-2 3CLpro-IN-37 is a non-covalent SARS-CoV-2 3CLpro inhibitor with an IC50 of 3.2 nM. SARS-CoV-2 3CLpro-IN-37 blocks the cleavage and replication of viral polyproteins. SARS-CoV-2 3CLpro-IN-37 is applicable to research related to COVID-19.

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SARS-CoV-2 3CLpro-IN-37

SARS-CoV-2 3CLpro-IN-37 Chemical Structure

CAS No. : 2920185-30-2

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SARS-CoV-2 3CLpro-IN-37 Related Antibodies

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Description

SARS-CoV-2 3CLpro-IN-37 is a non-covalent SARS-CoV-2 3CLpro inhibitor with an IC50 of 3.2 nM. SARS-CoV-2 3CLpro-IN-37 blocks the cleavage and replication of viral polyproteins. SARS-CoV-2 3CLpro-IN-37 is applicable to research related to COVID-19[1].

In Vitro

SARS-CoV-2 3CLpro-IN-37 (Compound 18f) inhibits viral replication in HEK293T-AT cells with an EC50 of 0.0081 μM and shows no cytotoxicity at concentrations above 5 μM[1].
SARS-CoV-2 3CLpro-IN-37 shows excellent metabolic stability, with 87.5% remaining in human liver microsomes and 90.1% remaining in rat liver microsomes, and has a fraction unbound of 25.9% in human serum and 29.4% in rat serum[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SARS-CoV-2 3CLpro-IN-37 Related Antibodies
Parmacokinetics
Species Dose Route CLtotal T1/2 F
Rat[1] 0.5 μmol/Kg i.v. 7.50 mL/min/kg 2.75 h /
Rat[1] 1.0 μmol/Kg p.o. / / 55.4 %
Molecular Weight

508.89

Formula

C24H18ClFN6O4
CAS No.
SMILES

N#CC1=CC(N2C(N(C3=CC=C(F)C(Cl)=C3)C4=CC(N5C[C@H](O)CC5)=NC(OC)=C4C2=O)=O)=CN=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SARS-CoV-2 3CLpro-IN-37 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SARS-CoV-2 3CLpro-IN-372920185-30-2COVID-19viral replicationSARS-CoV-2 3CL proteaseviral polyprotein cleavagerat serumhuman liver microsomeshuman serumHEK293T-AT cellsSARS-CoV-2rat liver microsomesInhibitorinhibitorinhibit

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