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Cat. No.: HY-182292

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SARS-CoV-2 3CLpro-IN-37

SARS-CoV-2 3CLpro-IN-37 is a non-covalent SARS-CoV-2 3CLpro inhibitor with an IC₅₀ of 3.2 nM. SARS-CoV-2 3CLpro-IN-37 blocks the cleavage and replication of viral polyproteins. SARS-CoV-2 3CLpro-IN-37 is applicable to research related to COVID-19.

For research use only. We do not sell to patients.

CAS No.: 2920185-30-2
Formula: C₂₄H₁₈ClFN₆O₄
Molecular Weight:508.89

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SARS-CoV-2 3CLpro-IN-37 Chemical Structure

CAS No.: 2920185-30-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Parmacokinetics
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

In Vitro

SARS-CoV-2 3CLpro-IN-37 (Compound 18f) inhibits viral replication in HEK293T-AT cells with an EC₅₀ of 0.0081 μM and shows no cytotoxicity at concentrations above 5 μM^[1].
SARS-CoV-2 3CLpro-IN-37 shows excellent metabolic stability, with 87.5% remaining in human liver microsomes and 90.1% remaining in rat liver microsomes, and has a fraction unbound of 25.9% in human serum and 29.4% in rat serum^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	CL_total	T_1/2	F
Rat^[1]	0.5 μmol/Kg	i.v.	7.50 mL/min/kg	2.75 h	/
Rat^[1]	1.0 μmol/Kg	p.o.	/	/	55.4 %

Chemical Information

CAS No. 2920185-30-2
Molecular Weight 508.89
Formula C₂₄H₁₈ClFN₆O₄
SMILES

N#CC1=CC(N2C(N(C3=CC=C(F)C(Cl)=C3)C4=CC(N5C[C@H](O)CC5)=NC(OC)=C4C2=O)=O)=CN=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Taoda Y, et al. Optimization of pyridopyrimidinedione derivatives as non-covalent SARS-CoV-2 3CL protease inhibitors. Bioorg Med Chem Lett. 2026 Jul;136:130619.
[Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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