Akt1&PKA-IN-2
Akt1&PKA-IN-2 (Compound R-29) is a AKT1 and PKA inhibitor with selectivity for CDK2, with IC50 values of 0.007 and 0.01 μM, respectively. Akt1&PKA-IN-2 is applicable for cancer research.
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- CAS No.: 1334108-00-7
- Formule: C20H17Cl2N3O
- Masse moléculaire:386.27
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
Akt1 0.007 μM (IC50) |
CDK2a 0.69 μM (IC50) |
PKA 0.01 μM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| U-87MG ATCC | IC50 |
0.24 μM
Compound: (R)-29
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Inhibition of AKT1-mediated PRAS40 phosphorylation in human U87MG cells after 1 hr in presence of 5% FBS by ELISA assay
Inhibition of AKT1-mediated PRAS40 phosphorylation in human U87MG cells after 1 hr in presence of 5% FBS by ELISA assay
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[PMID: 21824779] |
In Vitro
Chemical Information
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CAS No. 1334108-00-7
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Masse moléculaire 386.27
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Formule C20H17Cl2N3O
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SMILES
O=C(C1=CC2=C(C=NC=C2)C=C1)N[C@H](C3CNC3)C4=CC(Cl)=C(C=C4)Cl
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Akt1&PKA-IN-2 Related Classifications
HY-148868A Related Classifications
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