Akt1&PKA-IN-2
Akt1&PKA-IN-2 (Compound R-29) is a AKT1 and PKA inhibitor with selectivity for CDK2, with IC50 values of 0.007 and 0.01 μM, respectively. Akt1&PKA-IN-2 is applicable for cancer research.
For research use only. We do not sell to patients.
- CAS No.: 1334108-00-7
- Formula: C20H17Cl2N3O
- Molecular Weight:386.27
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
Akt1 0.007 μM (IC50) |
CDK2a 0.69 μM (IC50) |
PKA 0.01 μM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| U-87MG ATCC | IC50 |
0.24 μM
Compound: (R)-29
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Inhibition of AKT1-mediated PRAS40 phosphorylation in human U87MG cells after 1 hr in presence of 5% FBS by ELISA assay
Inhibition of AKT1-mediated PRAS40 phosphorylation in human U87MG cells after 1 hr in presence of 5% FBS by ELISA assay
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[PMID: 21824779] |
In Vitro
Akt1&PKA-IN-2 potently inhibits purified Akt1 kinase with an IC50 of 0.007 ± 0.007 μM, and also inhibits PKA and CDK2 kinases with higher IC50 values[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 1334108-00-7
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Molecular Weight 386.27
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Formula C20H17Cl2N3O
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SMILES
O=C(C1=CC2=C(C=NC=C2)C=C1)N[C@H](C3CNC3)C4=CC(Cl)=C(C=C4)Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Akt1&PKA-IN-2 Related Classifications
HY-148868A Related Classifications
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