PFK-IN-1
Based on 1 Customer Validation
PFK-IN-1 (compound 1) is a phosphofructokinase (PFK) inhibitor, with IC50 values of 0.41 and 0.23 μM against T.brucei and T.cruzi PFK, respectively, and an ED50 of 15.18 μg/mL for T.brucei. The half-lives of PFK-IN-1 in rat and mouse liver microsomes are 9.7 and 408 minutes, respectively.
For research use only. We do not sell to patients.
- Purity: 98.12%
- CAS No.: 735303-62-5
- Formula: C18H15Cl2N3O4S
- Molecular Weight:440.30
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MRC5 | ED50 |
46 μM
Compound: 1, MLS002158384-01
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Cytotoxicity against human MRC5 cells assessed as intracellular ATP content after 72 hrs by Cell titer-Glo luminiscent assay
Cytotoxicity against human MRC5 cells assessed as intracellular ATP content after 72 hrs by Cell titer-Glo luminiscent assay
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[PMID: 24900769] |
Chemical Information
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CAS No. 735303-62-5
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Appearance Solid
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Molecular Weight 440.30
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Formula C18H15Cl2N3O4S
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Color White to off-white
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SMILES
O=C(NC1=CC=C(S(=O)(NC2=NOC(C)=C2)=O)C=C1)CC3=CC=C(Cl)C(Cl)=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 125 mg/mL (283.90 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2712 mL | 11.3559 mL | 22.7118 mL | 56.7795 mL |
| 5 mM | 0.4542 mL | 2.2712 mL | 4.5424 mL | 11.3559 mL | |
| 10 mM | 0.2271 mL | 1.1356 mL | 2.2712 mL | 5.6779 mL | |
| 15 mM | 0.1514 mL | 0.7571 mL | 1.5141 mL | 3.7853 mL | |
| 20 mM | 0.1136 mL | 0.5678 mL | 1.1356 mL | 2.8390 mL | |
| 25 mM | 0.0908 mL | 0.4542 mL | 0.9085 mL | 2.2712 mL | |
| 30 mM | 0.0757 mL | 0.3785 mL | 0.7571 mL | 1.8926 mL | |
| 40 mM | 0.0568 mL | 0.2839 mL | 0.5678 mL | 1.4195 mL | |
| 50 mM | 0.0454 mL | 0.2271 mL | 0.4542 mL | 1.1356 mL | |
| 60 mM | 0.0379 mL | 0.1893 mL | 0.3785 mL | 0.9463 mL | |
| 80 mM | 0.0284 mL | 0.1419 mL | 0.2839 mL | 0.7097 mL | |
| 100 mM | 0.0227 mL | 0.1136 mL | 0.2271 mL | 0.5678 mL |
PFK-IN-1 Related Classifications
HY-128268 Related Classifications
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