1. Metabolic Enzyme/Protease
  2. Cytochrome P450

Proadifen hydrochloride (Synonyms: SKF-525A; U-5446; RP-5171)

Cat. No.: HY-B1311 Purity: 99.42%
Handling Instructions

Proadifen hydrochloride is a Cytochrome P450 inhibitor (IC50 = 19μM).

For research use only. We do not sell to patients.

Proadifen hydrochloride Chemical Structure

Proadifen hydrochloride Chemical Structure

CAS No. : 62-68-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
100 mg USD 60 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
250 mg USD 84 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
500 mg USD 144 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
1 g   Get quote  
5 g   Get quote  

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

Description

Proadifen hydrochloride is a Cytochrome P450 inhibitor (IC50 = 19μM). IC50 value: 19μM Target: P450 Proadifen HCl has many biochemical functions, some of which include: inhibitory effects on NOS1 (neuronal nitric oxide synthase; IC50 = 90 mM), adult mouse skeletal muscle AChR (acetyl choline receptor), hepatic drug metabolism via the CYP (cytochrome P450) system, CYP-dependent (cytochrome P450-dependent) arachidonate metabolism (90% at 50 μM), transmembrane calcium influx, and platelet thromboxane synthesis. This compound has also been shown to block KIR6.1 (ATP-sensitive inward rectifier potassium channel 8; IC50 = 4.4 mM) and stimulate endothelial cell prostacyclin production.

Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.5644 mL 12.8218 mL 25.6437 mL
5 mM 0.5129 mL 2.5644 mL 5.1287 mL
10 mM 0.2564 mL 1.2822 mL 2.5644 mL
Please refer to the solubility information to select the appropriate solvent.
Molecular Weight

389.96

Formula

C₂₃H₃₂ClNO₂

CAS No.

62-68-0

SMILES

O=C(OCCN(CC)CC)C(CCC)(C1=CC=CC=C1)C2=CC=CC=C2.[H]Cl

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 40 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 99.42%

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Product Name:
Proadifen hydrochloride
Cat. No.:
HY-B1311
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