2. Signaling Pathways
  3. PROTAC
  4. DUBTACs

DUBTACs

Deubiquitinase-targeting chimeras

 

DUBTACs Related Products (2):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-182350
    FXR DUBTAC IN-1 3081876-96-9
    FXR DUBTAC IN-1 (compound D11) is a deubiquitinase-targeting chimeric molecule (DUBTAC) that targets FXR, with a Ka value of 2.12e-5 M for FXR. FXR DUBTAC IN-1 recruits the deubiquitinase OTUB1, binds to OTUB1 and forms a ternary complex with FXR, reduces the polyubiquitination level of FXR, prevents FXR degradation via the ubiquitin-proteasome pathway, and elevates the protein level of FXR. FXR DUBTAC IN-1 can be used in the research of cholestatic liver injury.
    FXR DUBTAC IN-1
  • HY-183725
    MS5128 3060520-82-0
    MS5128 is an OTUB1-based deubiquitinase-targeting chimera (DUBTAC) targeting CFTR. MS5128 recruits OTUB1 to CFTR to induce deubiquitination and stabilization of CFTR. MS5128 can be used for the research of cystic fibrosis. (Blue: CFTR Ligand (HY-183724); Pink: OTUB1 Ligand (HY-13262); Black: Linker)
    MS5128