3081876-96-9
Chemical Structure
FXR DUBTAC modulator-1
- CAS No.: 3081876-96-9
- Formula:C43H66N4O7
- Molecular Weight:751.01
InChIKey: HYDUPTNRQFZKML-TVDWXYSWSA-N
SMILES: O[C@@H]1CC[C@@]2([C@]3(CC[C@@]4([C@@](CC[C@]4([C@@]3([C@@H](C([C@]2([H])C1)CC)O)[H])[H])([H])[C@@H](CCC(NCCCNC(CCC5=CC=C(N6C(CN(CC6)C(C=C)=O)=O)O5)=O)=O)C)C)[H])C
Biological Activity: FXR DUBTAC modulator-1 is a deubiquitinase-targeting chimeric molecule (DUBTAC) that targets FXR, with a Ka value of 2.12e-5 M for FXR. FXR DUBTAC modulator-1 recruits the deubiquitinase OTUB1, binds to OTUB1 and forms a ternary complex with FXR, reduces the polyubiquitination level of FXR, prevents FXR degradation via the ubiquitin-proteasome pathway, and elevates the protein level of FXR. FXR DUBTAC modulator-1 can be used in the research of cholestatic liver injury[1].
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FXR DUBTAC modulator-1 | FXR DUBTAC modulator-1 is a deubiquitinase-targeting chimeric molecule (DUBTAC) that targets FXR, with a Ka value of 2.12e-5 M for FXR. FXR DUBTAC modulator-1 recruits the deubiquitinase OTUB1, binds to OTUB1 and forms a ternary complex with FXR, reduces the polyubiquitination level of FXR, prevents FXR degradation via the ubiquitin-proteasome pathway, and elevates the protein level of FXR. FXR DUBTAC modulator-1 can be used in the research of cholestatic liver injury. | |||||||||||||||||||||
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