MS8572
Based on 1 Customer Validation
MS8572 is a selective OTUB1 covalent ligand. MS8572 covalently modifies the noncatalytic cysteine 23 residue of OTUB1 and does not inhibit OTUB1 deubiquitinase activity. MS8572 can be used for development of deubiquitinase-targeting chimeras for targeted protein stabilization.
For research use only. We do not sell to patients.
- Purity : 95.11%
- CAS No.: 3060517-63-4
- Formula: C17H23N3O2S
- Molecular Weight:333.45
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
OTUB1 |
In Vitro
MS8572 covalently modifies purified wild-type human OTUB1 protein, with a modification efficiency of 78%-84% when incubated at a ligand-to-protein ratio of 250:1 for 1 h, and does not inhibit the deubiquitinase activity of purified human OTUB1 protein[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3060517-63-4
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Appearance Oil
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Molecular Weight 333.45
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Formula C17H23N3O2S
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SMILES
CC1=CC=C(S1)C(N2CC3CC(C2)N3C(/C=C/CN(C)C)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (299.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9990 mL | 14.9948 mL | 29.9895 mL | 74.9738 mL |
| 5 mM | 0.5998 mL | 2.9990 mL | 5.9979 mL | 14.9948 mL | |
| 10 mM | 0.2999 mL | 1.4995 mL | 2.9990 mL | 7.4974 mL | |
| 15 mM | 0.1999 mL | 0.9997 mL | 1.9993 mL | 4.9983 mL | |
| 20 mM | 0.1499 mL | 0.7497 mL | 1.4995 mL | 3.7487 mL | |
| 25 mM | 0.1200 mL | 0.5998 mL | 1.1996 mL | 2.9990 mL | |
| 30 mM | 0.1000 mL | 0.4998 mL | 0.9997 mL | 2.4991 mL | |
| 40 mM | 0.0750 mL | 0.3749 mL | 0.7497 mL | 1.8743 mL | |
| 50 mM | 0.0600 mL | 0.2999 mL | 0.5998 mL | 1.4995 mL | |
| 60 mM | 0.0500 mL | 0.2499 mL | 0.4998 mL | 1.2496 mL | |
| 80 mM | 0.0375 mL | 0.1874 mL | 0.3749 mL | 0.9372 mL | |
| 100 mM | 0.0300 mL | 0.1499 mL | 0.2999 mL | 0.7497 mL |
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