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Cat. No.: HY-181721

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Dopamine D3 receptor agonist 1

Dopamine D3 receptor agonist 1 is a dopamine D3 Receptor agonist with a K_i value of 0.268 nM. Dopamine D3 receptor agonist 1 exhibits metabolic stability in rat liver microsomes. Dopamine D3 receptor agonist 1 can be used to study severe mental disorders comorbid with substance use disorders.

For research use only. We do not sell to patients.

Formula: C₂₂H₃₂Cl₂N₂O₂
Molecular Weight:427.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Dopamine D3 receptor agonist 1 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
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Biological Activity

Description

IC₅₀ & Target^[1]

D₃ Receptor

0.268 nM (Ki)

All Dopamine Receptor Isoforms :

In Vitro

Dopamine D3 receptor agonist 1 (Compound 8) (10 μM; up to 60 min at 37°C) exhibits high metabolic stability in rat liver microsomes, with a half-life of 117.7 min^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 427.41
Formula C₂₂H₃₂Cl₂N₂O₂
SMILES

ClC1=CC=CC(N2CCN(CC[C@H]3CC[C@H](CC(COC)=O)CC3)CC2)=C1Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Vogt CD, et al. Tailoring cariprazine for dual disorders via secondary pharmacophore optimization. Eur J Med Chem. 2026;307:118654. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Dopamine D3 receptor agonist 1

All Dopamine Receptor Isoforms