ED-594

Cat. No.: HY-182255: Data Sheet Handling Instructions
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ED-594 is the glucuronide form of NB-506. ED-594 is one of the major metabolites of NB-506 in rat bile, mouse liver microsomes, rat liver microsomes and human liver microsomes.

For research use only. We do not sell to patients.

ED-594 Chemical Structure

CAS No. : 217187-87-6

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Description

ED-594 is the glucuronide form of NB-506. ED-594 is one of the major metabolites of NB-506 in rat bile, mouse liver microsomes, rat liver microsomes and human liver microsomes^[1].

IC₅₀ & Target^[1]

Human Endogenous Metabolite

In Vitro

ED-594 (15-30 min) is formed via glucuronidation of NB-506 in mouse, rat, and human liver microsomes with distinct apparent kinetic parameters, and no ED-594 formation occurs in dog liver microsomes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

738.61

Formula

C₃₃H₃₀N₄O₁₆

CAS No.

217187-87-6

SMILES

O=C1C2=C3C(N([C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)C5=C(O)C=CC=C53)=C6C(C7=CC=CC(O[C@@H]8O[C@@H]([C@H]([C@@H]([C@H]8O)O)O)C(O)=O)=C7N6)=C2C(N1NC=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Takenaga N, et al. In vitro metabolism of a new anticancer agent, 6-N-formylamino-12, 13-dihydro-1,11-dihydroxy-13-(beta-D-glucopyranosil)5H-indolo+ ++[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione (NB-506), in mice, rats, dogs, and humans. Drug Metab Dispos. 1999 Feb;27(2):213-20. [Content Brief]

ED-594 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ED-594217187-87-6ED594ED 594Endogenous Metaboliterat liver microsomesdog liver microsomesrat bilemouse liver microsomeshuman liver microsomesglucuronidationInhibitorinhibitorinhibit

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