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製品番号: HY-155051

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Antiproliferative agent-25

Antiproliferative agent-25 (Compound 3s4) is a selective PRMT5 inhibitor (IC₅₀: 0.11 μM). Antiproliferative agent-25 up-regulates hnRNP E1 protein level. Antiproliferative agent-25 forms H-bond interactions with SAM and E444 residue of PRMT5. Antiproliferative agent-25 has antiproliferative effects against A549 cells by inducing apoptosis and inhibiting cell migration. Antiproliferative agent-25 has high clearances with T_1/2 of only 21.8 and 4.7 min in human and rat liver microsomes.

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分子式: C₂₀H₂₁BrN₂O₂
分子量:401.30

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Antiproliferative agent-25 構造式

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

0.11 μM (PRMT5)^[1]

Histone Methyltransferase アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	14.25 μM Compound: 3s4	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay	[PMID: 37429083]
HepG2	IC₅₀	58.14 μM Compound: 3s4	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay	[PMID: 37429083]
L02	IC₅₀	>100 μM Compound: 3s4	Antiproliferative activity against human L02 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay Antiproliferative activity against human L02 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay	[PMID: 37429083]
MCF7	IC₅₀	28.89 μM Compound: 3s4	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay	[PMID: 37429083]
MDA-MB-231	IC₅₀	21.33 μM Compound: 3s4	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay	[PMID: 37429083]

化学情報

分子量 401.30
分子式 C₂₀H₂₁BrN₂O₂
SMILES

O[C@@H](CN1C=CC2=C1C=C(Br)C=C2)CN(C3)CCC4=C3C=CC(O)=C4
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (267 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Chu WH, et al. Discovery of tetrahydroisoquinolineindole derivatives as first dual PRMT5 inhibitors/hnRNP E1 upregulators: Design, synthesis and biological evaluation. Eur J Med Chem. 2023 Oct 5;258:115625. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Antiproliferative agent-25

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生物活性
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- IC₅₀ & Target
化学情報
純度とドキュメンテーション
参考文献

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Antiproliferative agent-25

Histone Methyltransferase アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Antiproliferative agent-25 関連分類

HY-155051 関連分類