2. Apoptosis Epigenetics
  3. Histone Methyltransferase Apoptosis
  4. Antiproliferative agent-25

Antiproliferative agent-25 (Compound 3s4) is a selective PRMT5 inhibitor (IC50: 0.11 μM). Antiproliferative agent-25 up-regulates hnRNP E1 protein level. Antiproliferative agent-25 forms H-bond interactions with SAM and E444 residue of PRMT5. Antiproliferative agent-25 has antiproliferative effects against A549 cells by inducing apoptosis and inhibiting cell migration. Antiproliferative agent-25 has high clearances with T1/2 of only 21.8 and 4.7 min in human and rat liver microsomes.

For research use only. We do not sell to patients.

Antiproliferative agent-25

Antiproliferative agent-25 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Antiproliferative agent-25 Related Antibodies

Top Publications Citing Use of Products

View All Histone Methyltransferase Isoform Specific Products:

View All Isoforms
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D ASH1L/KMT2H SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 NSD3/WHSC1L1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Antiproliferative agent-25 (Compound 3s4) is a selective PRMT5 inhibitor (IC50: 0.11 μM). Antiproliferative agent-25 up-regulates hnRNP E1 protein level. Antiproliferative agent-25 forms H-bond interactions with SAM and E444 residue of PRMT5. Antiproliferative agent-25 has antiproliferative effects against A549 cells by inducing apoptosis and inhibiting cell migration. Antiproliferative agent-25 has high clearances with T1/2 of only 21.8 and 4.7 min in human and rat liver microsomes[1].

IC50 & Target

0.11 μM (PRMT5)[1]
Cellular Effect
Cell Line Type Value Description References
A549 IC50
14.25 μM
Compound: 3s4
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay
[PMID: 37429083]
HepG2 IC50
58.14 μM
Compound: 3s4
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay
[PMID: 37429083]
L02 IC50
> 100 μM
Compound: 3s4
Antiproliferative activity against human L02 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay
Antiproliferative activity against human L02 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay
[PMID: 37429083]
MCF7 IC50
28.89 μM
Compound: 3s4
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay
[PMID: 37429083]
MDA-MB-231 IC50
21.33 μM
Compound: 3s4
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay
[PMID: 37429083]
Molecular Weight

401.30

Formula

C20H21BrN2O2
SMILES

O[C@@H](CN1C=CC2=C1C=C(Br)C=C2)CN(C3)CCC4=C3C=CC(O)=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Antiproliferative agent-25 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antiproliferative agent-25Antiproliferative agent25Antiproliferative agent 25Histone MethyltransferaseApoptosisA549liver microsomecancerantiproliferativecell migrationInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Antiproliferative agent-25
Cat. No.:
HY-155051
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.