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Results for "

PI3K+inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (1) Akt (7) Amyloid-β (1) Antibiotic (2) Apoptosis (37) Autophagy (16) Bacterial (1) Bcl-2 Family (1) Beta-secretase (1) Biochemical Assay Reagents (1) Casein Kinase (2) Caspase (3) Cathepsin (1) COX (2) Cytochrome P450 (1) DNA-PK (4) Dopamine Receptor (3) Drug Intermediate (1) Drug Metabolite (1) EGFR (1) Endogenous Metabolite (3) Isotope-Labeled Compounds (2) MEK (3) Mitophagy (11) mTOR (7) NF-κB (1) Organoid (2) P-glycoprotein (1) PARP (3) PERK (2) PI3K (106) Polo-like Kinase (PLK) (2) PPAR (1) Reactive Oxygen Species (ROS) (10) Reference Standards (11) Syk (1) TGF-beta/Smad (3)
By Research Areas:	Cancer (100) Cardiovascular Disease (1) Infection (2) Inflammation/Immunology (14) Metabolic Disease (5) Neurological Disease (10)

By Targets:

Adrenergic Receptor (1)

Akt (7)

Amyloid-β (1)

Antibiotic (2)

Apoptosis (37)

Autophagy (16)

Bacterial (1)

Bcl-2 Family (1)

Beta-secretase (1)

Biochemical Assay Reagents (1)

Casein Kinase (2)

Caspase (3)

Cathepsin (1)

COX (2)

Cytochrome P450 (1)

DNA-PK (4)

Dopamine Receptor (3)

Drug Intermediate (1)

Drug Metabolite (1)

EGFR (1)

Endogenous Metabolite (3)

Isotope-Labeled Compounds (2)

MEK (3)

Mitophagy (11)

mTOR (7)

NF-κB (1)

Organoid (2)

P-glycoprotein (1)

PARP (3)

PERK (2)

PI3K (106)

Polo-like Kinase (PLK) (2)

PPAR (1)

Reactive Oxygen Species (ROS) (10)

Reference Standards (11)

Syk (1)

TGF-beta/Smad (3)

By Research Areas:

Cancer (100)

Cardiovascular Disease (1)

Infection (2)

Inflammation/Immunology (14)

Metabolic Disease (5)

Neurological Disease (10)

110

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

GMP Molecules

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-19312

3-Methyladenine Maximum Cited Publications 1233 Publications Verification 3-MA	PI3K Autophagy Mitophagy Endogenous Metabolite	Cancer
3-Methyladenine (3-MA) is a *PI3K* inhibitor. 3-Methyladenine is a widely used inhibitor of autophagy via its inhibitory effect on class III PI3K .

HY-18085

Quercetin 195+ Cited Publications	Reactive Oxygen Species (ROS) PI3K Autophagy Mitophagy Apoptosis	Cancer
Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a *PI3K* inhibitor with IC₅₀ of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .

HY-10197

Wortmannin 160+ Cited Publications SL-2052; KY-12420	Organoid PI3K Polo-like Kinase (PLK) Autophagy Antibiotic	Cancer
Wortmannin (SL-2052; KY-12420) is a potent, selective and irreversible *PI3K* inhibitor with an IC₅₀ of 3 nM. Wortmannin also blocks autophagy formation, and potently inhibits Polo-like kinase 1 (PlK1) and *Plk3* with IC₅₀s of 5.8 and 48 nM, respectively ^[3].

HY-110171

iMDK 5 Publications Verification	PI3K	Cancer
iMDK is a potent *PI3K* inhibitor and inhibits the growth factor MDK (also known as midkine or MK). iMDK suppresses non-small cell lung cancer (NSCLC) cooperatively with A MEK inhibitor without harming normal cells and mice .

HY-18085A

Quercetin hydrate 195+ Cited Publications	PI3K Autophagy Mitophagy Apoptosis Reactive Oxygen Species (ROS)	Cancer
Quercetin hydrate, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a *PI3K* inhibitor with IC₅₀ of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .

HY-70063

Buparlisib 85+ Cited Publications BKM120; NVP-BKM120	PI3K Apoptosis	Cancer
Buparlisib (BKM120; NVP-BKM120) is a pan-class I *PI3K* inhibitor, with blood-brain barrier permeability. Buparlisib has IC₅₀s of 52, 166, 116 and 262 nM for p110α, p110β, p110δ and p110γ, respectively ^[3] .

HY-15346

Copanlisib 30+ Cited Publications BAY 80-6946	PI3K Apoptosis	Cancer
Copanlisib (BAY 80-6946) is a potent, selective and ATP-competitive pan-class I *PI3K* inhibitor, with IC₅₀s of 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ, respectively. Copanlisib has more than 2,000-fold selectivity against other lipid and protein kinases, except for mTOR. Copanlisib has superior antitumor activity .

HY-15346A

Copanlisib dihydrochloride 30+ Cited Publications BAY 80-6946 dihydrochloride	PI3K Apoptosis	Cancer
Copanlisib dihydrochloride (BAY 80-6946 dihydrochloride) is a potent, selective and ATP-competitive pan-class I *PI3K* inhibitor, with IC₅₀s of 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ, respectively. Copanlisib dihydrochloride has more than 2,000-fold selectivity against other lipid and protein kinases, except for mTOR. Copanlisib dihydrochloride has superior antitumor activity .

HY-10108A

LY294002 hydrochloride 1115+ Cited Publications	PI3K Casein Kinase DNA-PK Apoptosis	Cancer
LY294002 hydrochloride is a potent and broad-spectrum *PI3K* inhibitor, with IC₅₀ values of 0.5, 0.57, and 0.97 μM for P110α, P110δ and P110β, respectively. LY294002 hydrochloride also inhibits CK2 with an IC₅₀ of 98 nM. LY294002 hydrochloride can be used for pancreatic cancer research ^[3].

HY-13898

Taselisib 20+ Cited Publications GDC-0032; RG-7604	PI3K	Cancer
Taselisib (GDC-0032) is a potent *PI3K* inhibitor targets PIK3CA mutations, with K_is of 0.12 nM, 0.29 nM, 0.97 nM, and 9.1 nM for PI3Kδ, PI3Kα, PI3Kγ and PI3Kβ, respectively.

HY-15900

Voxtalisib 5 Publications Verification XL765; SAR245409	PI3K mTOR	Cancer
Voxtalisib (XL765) is a potent *PI3K* inhibitor, which has a similar activity toward class I PI3K (IC₅₀s=39, 113, 9 and 43?nM for p110α, p110β, p110γ and p110δ, respectively), also inhibits DNA-PK (IC₅₀=150?nM) and mTOR (IC₅₀=157?nM). Voxtalisib (XL765) inhibits mTORC1 and mTORC2 with IC₅₀s of 160 and 910 nM, respectively.

HY-P0118B

Disitertide diammonium 15+ Cited Publications P144 diammonium	TGF-beta/Smad PI3K Apoptosis	Cancer
Disitertide (P144) diammonium is a peptidic transforming growth factor-beta 1 (TGF-β1) inhibitor specifically designed to block the interaction with its receptor. Disitertide diammonium is also a *PI3K* inhibitor and an apoptosis inducer ^[3] .

HY-N0146

Quercetin dihydrate 190+ Cited Publications	PI3K Apoptosis	Inflammation/Immunology Cancer
Quercetin dihydrate, a natural flavonoid, is a stimulator of recombinant SIRT1 and a *PI3K* inhibitor with *IC₅₀s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K* γ, PI3K δ and PI3K β, respectively .**

HY-18085R

Quercetin (Standard)	Reactive Oxygen Species (ROS) Reference Standards PI3K Autophagy Mitophagy Apoptosis	Cancer
Quercetin (Standard) is the analytical standard of Quercetin. This product is intended for research and analytical applications. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .

HY-12030

PIK-90 5 Publications Verification	PI3K DNA-PK	Cancer
PIK-90 is a DNA-PK and *PI3K* inhibitor, which inhibits p110α, p110γ and DNA-PK with IC₅₀s of 11, 18 and 13 nM, respectively.

HY-50847

ZSTK474 15+ Cited Publications	PI3K Autophagy	Cancer
ZSTK474 is an ATP-competitive pan-class I *PI3K* inhibitor with IC₅₀s of 16 nM, 44 nM, 4.6 nM and 49 nM for PΙ3Κα, PI3Kβ, PI3Kδ and PI3Kγ, respectively.

HY-12330

AZD8186 5+ Cited Publications	PI3K	Cancer
AZD8186 is a *PI3K* inhibitor, which potently inhibits PI3Kβ (IC₅₀=4 nM) and PI3Kδ (IC50₅₀=12 nM) with selectivity over PI3Kα (IC₅₀=35 nM) and PI3Kγ (IC₅₀=675 nM).

HY-12794

Vps34-PIK-III 10+ Cited Publications	PI3K Autophagy	Neurological Disease Cancer
Vps34-PIK-III is an orally active and selective VPS34 inhibitor (IC₅₀=18 nM). Vps34-PIK-III effectively inhibits autophagy and can be used as a molecular tool. vps34-PIK-III is also a *PI3K* inhibitor that inhibits the expression of genes in liver cancer stem cells (CSCs) ^[3].

HY-P0118

Disitertide 15+ Cited Publications P144	TGF-beta/Smad PI3K Apoptosis	Cancer
Disitertide (P144) is a peptidic transforming growth factor-beta 1 (TGF-β1) inhibitor specifically designed to block the interaction with its receptor. Disitertide (P144) is also a *PI3K* inhibitor and an apoptosis inducer ^[3] .

HY-15856B

Flupentixol dihydrochloride 2 Publications Verification Flupenthixol dihydrochloride	Dopamine Receptor PI3K Apoptosis	Neurological Disease Cancer
Flupentixol is an orally active D₁/D₂ dopamine receptor antagonist and new *PI3K* inhibitor (PI3Kα IC₅₀=127 nM). Flupentixol shows anti-proliferative activity to cancer cells and induces apoptosis. Flupentixol can also be used in schizophrenia, anxiolytic and depressive research ^[3].

HY-15466

Izorlisib 3 Publications Verification CH5132799	PI3K	Cancer
Izorlisib (CH5132799) is a selective class I *PI3K* inhibitor. Izorlisib inhibits class I PI3Ks, particularly PI3Kα, with an IC₅₀ of 14 nM.

HY-15180

Buparlisib Hydrochloride 85+ Cited Publications BKM120 Hydrochloride; NVP-BKM120 Hydrochloride	PI3K Apoptosis	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Buparlisib Hydrochloride (BKM120 Hydrochloride) is a CNS-penetrant pan-class I *PI3K* inhibitor, with IC₅₀ of 52 nM/166 nM/116 nM/262 nM for p110α/p110β/p110δ/p110γ, respectively.

HY-17044A

Duvelisib (R enantiomer) IPI-145 R enantiomer; INK1197 R enantiomer	PI3K	Cancer
Duvelisib R enantiomer is a *PI3K* inhibitor, which is the less active enantiomer of Duvelisib.

HY-15868

HS-173 5+ Cited Publications	PI3K Apoptosis	Cancer
HS-173 is a novel *PI3K* inhibitor, that is used for cancer treatment.

HY-18085G

Quercetin 1 Publications Verification	PI3K Autophagy Mitophagy Apoptosis Reactive Oxygen Species (ROS)	Cancer
Quercetin GMP is Quercetin (HY-18085) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Quercetin is a flavonoid antioxidant, a *PI3K* inhibitor and a SIRT1 Activator ^[3] .

HY-13333

NVP-BAG956 BAG 956	PI3K	Cancer
NVP-BAG956 is an ATP-competitive *PI3K* inhibitor with IC50s of 34, 56, 112 and 444 nM for PI3Kδ, PI3Kα, PI3Kγ and PI3Kβ, respectively.

HY-18085S1

Quercetin-d3 1 Publications Verification	Isotope-Labeled Compounds PI3K Autophagy Mitophagy Reactive Oxygen Species (ROS) Apoptosis	Cancer
Quercetin-d₃ is the deuterium labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC₅₀ of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .

HY-162713

MTX-531	EGFR PI3K PPAR	Cancer
MTX-531 is an oral drug that inhibits EGFR (with an IC₅₀ of 14.7 nM) and *PI3K* (with IC₅₀ values of 6.4, 233, 8.3, and 1.1 nM for PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ respectively), and it has anti-tumor effects. MTX-531 also acts as a weak agonist of PPARγ, with an IC₅₀ of 2.5 µM, helping to alleviate hyperglycemia induced by PI3K inhibitors .

HY-60298

6-Bromo-1H-indazole	Biochemical Assay Reagents Drug Intermediate	Others
6-Bromo-1H-indazole is a PI3K inhibitor intermediate. 6-Bromo-1H-indazole can be used in the research of respiratory diseases .

HY-136198

SRX3207	Syk PI3K	Cancer
SRX3207 is an orally active and first-in-class dual *Syk/PI3K* inhibitor, with IC₅₀ values of 10.7 nM and 861 nM for Syk and PI3Kα, respectively. SRX3207 relieves tumor immunosuppression .

HY-143404

PI3K-IN-30 3 Publications Verification	PI3K	Cancer
PI3K-IN-30 (compound 6d) is a potent *PI3K* inhibitor with IC₅₀s of 5.1, 136, 30.7 and 8.9 nM for PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ, respectively .

HY-110109

ETP-45658	PI3K DNA-PK mTOR	Cancer
ETP-45658 is a potent *PI3K* inhibitor, with IC₅₀s of 22.0 nM, 39.8 nM, 129.0 nM and 717.3 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ, respectively. ETP-45658 also can inhibit DNA-PK (IC₅₀=70.6 nM) and mTOR (IC₅₀=152.0 nM). ETP-45658 can be used for the research of cancer .

HY-110171A

iMDK quarterhydrate 5 Publications Verification	PI3K	Cancer
iMDK quarterhydrate is a potent *PI3K* inhibitor and inhibits the growth factor MDK (also known as midkine or MK). iMDK quarterhydrate suppresses non-small cell lung cancer (NSCLC) cooperatively with A MEK inhibitor without harming normal cells and mice .

HY-111383

LX2343	Beta-secretase PI3K Amyloid-β Autophagy	Neurological Disease
LX2343 is a BACE1 enzyme inhibitor with an IC₅₀ value of 11.43±0.36 μM. LX2343 acts as a non-ATP competitive *PI3K* inhibitor with an IC₅₀ of 15.99±3.23 μM. LX2343 stimulates autophagy in its promotion of Aβ clearance.

HY-19312S

3-Methyladenine-d3	PI3K Autophagy Mitophagy Endogenous Metabolite	Cancer
3-Methyladenine-d₃ is the deuterium labeled 3-Methyladenine . 3-Methyladenine (3-MA) is a PI3K inhibitor. 3-Methyladenine is a widely used inhibitor of autophagy via its inhibitory effect on class III PI3K .

HY-19312R

3-Methyladenine (Standard) 3-MA (Standard)	Reference Standards PI3K Autophagy Mitophagy Endogenous Metabolite	Cancer
3-Methyladenine (Standard) is the analytical standard of 3-Methyladenine. This product is intended for research and analytical applications. 3-Methyladenine (3-MA) is a PI3K inhibitor. 3-Methyladenine is a widely used inhibitor of autophagy via its inhibitory effect on class III PI3K .

HY-147419

Vulolisib	PI3K	Cancer
Vulolisib is a potent and orally active phosphatidylinositol 3-kinase (PI3K) inhibitor, with IC₅₀ values of 0.2 nM, 168 nM, 90 nM and 49 nM for PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ, respectively. Antiproliferative and antineoplastic activity .

HY-162382

KTC1101	PI3K Akt mTOR	Cancer
KTC1101 is an orally active pan-PI3K inhibitor. KTC1101 can inhibit the *PI3K* signaling pathway, reduce downstream AKT and mTOR phosphorylation, and reduces the expression of Ki67. The anti-tumor effect of KTC1101 has a dual mechanism of action: directly inhibiting tumor cell growth and dynamically enhancing immune response .

HY-167876

PQR514	PI3K	Cancer
PQR514 is a potent PI3K inhibitor with anticancer activity. PQR514 is able to inhibit cancer cell proliferation. PQR514 showed significant antitumor activity in the OVCAR-3 xenograft model, with the required concentration being approximately one-eighth that of PQR309. PQR514 has good pharmacokinetic properties and minimal brain penetration, making it an optimized candidate compound for inhibiting systemic tumors .

HY-17457

Levalbuterol hemitartrate Levosalbutamol hemitartrate	Adrenergic Receptor PI3K	Inflammation/Immunology
Levalbuterol (Levosalbutamol) hemitartrate is a β₂-adrenergic receptor agonist and *PI3K* inhibitor. Levalbuterol hemitartrate inhibits PI3K activity, reduces NF-κB and Rb protein expression, activates the cAMP/PKA pathway, and stimulates cAMP release. Levalbuterol hemitartrate relaxes airway smooth muscle, reduces intracellular calcium levels, and inhibits spasmogen-induced contractions. Levalbuterol hemitartrate can be used for the research of moderate-to-severe asthma ^[3].

HY-10812

GNE-490	PI3K mTOR	Cancer
GNE-490, a (thienopyrimidin-2-yl)aminopyrimidine, is a potent pan-PI3K* inhibitor* with IC₅₀s of 3.5 nM, 25 nM, 5.2 nM, 15 nM for PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ, respectively. GNE-490 has >200 fold selectivity for mTOR (IC₅₀=750 nM). GNE-490 shows potent suppression efficacy profile against MCF7.1 breast cancer xenograft model .

HY-15856A

Flupentixol Flupenthixol	Dopamine Receptor PI3K Apoptosis	Neurological Disease
Flupentixol is an orally active D₁/D₂ dopamine receptor antagonist and new *PI3K* inhibitor (PI3Kα IC₅₀=127 nM). Flupentixol shows anti-proliferative activity to cancer cells and induces apoptosis. Flupentixol can also be used in schizophrenia, anxiolytic and depressive research ^[3].

HY-18085S2

Quercetin-13C3	Isotope-Labeled Compounds PI3K Autophagy Mitophagy Reactive Oxygen Species (ROS) Apoptosis	Cancer
Quercetin- ¹³C₃ is the ¹³C-labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC₅₀ of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .

HY-124535

TGX-115	PI3K	Metabolic Disease
TGX-115 is a p110β/p110δ-selective, *PI3-K* inhibitor. TGX-115 blocks p110β-mediated Akt phosphorylation induced by lysophosphatidic acid (LPA) in L6 myotubes, reduces insulin-stimulated *PI(3,4)P2* and *PIP3* levels in 3T3-L1 adipocytes. TGX-115 can be used for the study of diabetes mellitus .

HY-16355

NVP-QAV-572	PI3K	Cancer
NVP-QAV-572 is a *PI3K* inhibitor extracted from patent US7998990B2, Compound Example 8, has an IC₅₀ of 10 nM.

HY-111209

Pichromene S14161	PI3K	Cancer
Pichromene (S14161) is an anticancer agent and weak *PI3K* inhibitor. Pichromene can effectively inhibit tumor growth in leukemia mouse models and can be used in cancer research .

HY-142676

PI3K-IN-26	PI3K	Inflammation/Immunology Cancer
PI3K-IN-26 is a potent *PI3K* inhibitor with an IC₅₀ of 36 nM for SU-DHL-6 cells (WO2016066142A1, compound 1) .

HY-145358

FAP-PI3KI1	PI3K	Cancer
FAP-PI3KI1 is a fibroblast-activated protein (FAP)-targeted *PI3K* inhibitor that selectively targets FAP-expressing human idiopathic pulmonary fibrosis (IPF) cells and effectively inhibits collagen synthesis and reduces collagen deposition .

HY-146260

NVP-CLR457	PI3K	Cancer
NVP-CLR457 (compound 40) is an orally active, potent and balanced pan-class I *PI3K* inhibitor. NVP-CLR457 shows a clear dose-dependent PK/PD/efficacy relationship. NVP-CLR457 has antitumor activity .

HY-18085S

Quercetin-d5	PI3K Autophagy Mitophagy Apoptosis	Cancer
Quercetin-d₅ is a deuterium labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC₅₀ of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .

Cat. No.	Product Name	Type

HY-18085G

Quercetin 1 Publications Verification	Fluorescent Dyes
Quercetin GMP is Quercetin (HY-18085) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Quercetin is a flavonoid antioxidant, a *PI3K* inhibitor and a SIRT1 Activator ^[3] .

Cat. No.	Product Name	Type

HY-18085G

Quercetin 1 Publications Verification	Biochemical Assay Reagents
Quercetin GMP is Quercetin (HY-18085) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Quercetin is a flavonoid antioxidant, a *PI3K* inhibitor and a SIRT1 Activator ^[3] .

HY-60298

6-Bromo-1H-indazole	Biochemical Assay Reagents
6-Bromo-1H-indazole is a PI3K inhibitor intermediate. 6-Bromo-1H-indazole can be used in the research of respiratory diseases .

Cat. No.	Product Name	Target	Research Area

HY-P0118B

Disitertide diammonium 15+ Cited Publications P144 diammonium	TGF-beta/Smad PI3K Apoptosis	Cancer
Disitertide (P144) diammonium is a peptidic transforming growth factor-beta 1 (TGF-β1) inhibitor specifically designed to block the interaction with its receptor. Disitertide diammonium is also a *PI3K* inhibitor and an apoptosis inducer ^[3] .

HY-P0118

Disitertide 15+ Cited Publications P144	TGF-beta/Smad PI3K Apoptosis	Cancer
Disitertide (P144) is a peptidic transforming growth factor-beta 1 (TGF-β1) inhibitor specifically designed to block the interaction with its receptor. Disitertide (P144) is also a *PI3K* inhibitor and an apoptosis inducer ^[3] .

HY-P0118A

Disitertide TFA P144 TFA	TGF-beta/Smad PI3K Apoptosis	Cancer
Disitertide (P144) TFA is a peptidic transforming growth factor-beta 1 (TGF-β1) inhibitor specifically designed to block the interaction with its receptor. Disitertide TFA is also a *PI3K* inhibitor and an apoptosis inducer ^[3] .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-19312

3-Methyladenine Maximum Cited Publications 1233 Publications Verification 3-MA	Natural Products Microorganisms Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	PI3K Autophagy Mitophagy Endogenous Metabolite
3-Methyladenine (3-MA) is a *PI3K* inhibitor. 3-Methyladenine is a widely used inhibitor of autophagy via its inhibitory effect on class III PI3K .

HY-18085

Quercetin 195+ Cited Publications	Flavonols Classification of Application Fields Anti-aging Endocrine diseases Plants Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Immune System Disorder Microorganisms other families Leguminosae Sunscreen Disease markers Cosmetic Research Glycyrrhiza uralensis Fisch. Disease Research Fields Source Classification Cancer	Reactive Oxygen Species (ROS) PI3K Autophagy Mitophagy Apoptosis
Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a *PI3K* inhibitor with IC₅₀ of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .

HY-10197

Wortmannin 160+ Cited Publications SL-2052; KY-12420	Infection Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Antibiotics Endogenous metabolite Disease Research Fields Other Antibiotics Source Classification	Organoid PI3K Polo-like Kinase (PLK) Autophagy Antibiotic
Wortmannin (SL-2052; KY-12420) is a potent, selective and irreversible *PI3K* inhibitor with an IC₅₀ of 3 nM. Wortmannin also blocks autophagy formation, and potently inhibits Polo-like kinase 1 (PlK1) and *Plk3* with IC₅₀s of 5.8 and 48 nM, respectively ^[3].

HY-N0146

Quercetin dihydrate 190+ Cited Publications	Flavonols Flavonoids other families Classification of Application Fields Phenols Polyphenols Plants Disease Research Fields Source Classification Cancer	PI3K Apoptosis
Quercetin dihydrate, a natural flavonoid, is a stimulator of recombinant SIRT1 and a *PI3K* inhibitor with *IC₅₀s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K* γ, PI3K δ and PI3K β, respectively .**

HY-18085R

Quercetin (Standard)	Flavonols Structural Classification Endocrine diseases Plants Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Immune System Disorder Microorganisms other families Leguminosae Disease markers Glycyrrhiza uralensis Fisch. Source Classification	Reactive Oxygen Species (ROS) Reference Standards PI3K Autophagy Mitophagy Apoptosis
Quercetin (Standard) is the analytical standard of Quercetin. This product is intended for research and analytical applications. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .

HY-19312R

3-Methyladenine (Standard) 3-MA (Standard)	Structural Classification Natural Products Microorganisms Endogenous metabolite Source Classification	Reference Standards PI3K Autophagy Mitophagy Endogenous Metabolite
3-Methyladenine (Standard) is the analytical standard of 3-Methyladenine. This product is intended for research and analytical applications. 3-Methyladenine (3-MA) is a PI3K inhibitor. 3-Methyladenine is a widely used inhibitor of autophagy via its inhibitory effect on class III PI3K .

HY-N0146R

Quercetin dihydrate (Standard)	Flavonols Structural Classification Flavonoids other families Phenols Polyphenols Plants Source Classification	Reference Standards PI3K Apoptosis
Quercetin (dihydrate) (Standard) is the analytical standard of Quercetin (dihydrate). This product is intended for research and analytical applications. Quercetin dihydrate, a natural flavonoid, is a stimulator of recombinant SIRT1 and a PI3K inhibitor with IC₅₀s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .

HY-10197R

Wortmannin (Standard) SL-2052 (Standard); KY-12420 (Standard)	Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Organoid Reference Standards PI3K Polo-like Kinase (PLK) Autophagy Antibiotic
Wortmannin (Standard) is the analytical standard of Wortmannin. This product is intended for research and analytical applications. Wortmannin (SL-2052; KY-12420) is a potent, selective and irreversible PI3K inhibitor with an IC50 of 3 nM. Wortmannin also blocks autophagy formation, and potently inhibits Polo-like kinase 1 (PlK1) and Plk3 with IC50s of 5.8 and 48 nM, respectively ^[3].

HY-N18161

Isopsoralidin	Structural Classification Monophenols Flavonoids Rutaceae Phenols Plants Other Flavonoids Zanthoxylum acanthopodiumDC. Source Classification	PI3K Cytochrome P450
Isopsoralidin is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potential hepatotoxicity and CYP2D6 inhibitory activity .

HY-N10342

Cajanol	Structural Classification Flavonoids Leguminosae Phenols Polyphenols Plants Isoflavones Cajanus cajan (L.) Millsp. Source Classification	Apoptosis Bcl-2 Family Caspase PARP Reactive Oxygen Species (ROS) Bacterial PI3K Akt NF-κB P-glycoprotein
Cajanol is an isoflavanone that can be isolated from the roots of Cajanus cajan (L.) Millsp. . Cajanol inhibits cancer cell proliferation and induces cancer cell apoptosis. Cajanol promotes the expression of Bax, inhibits the expression of Bcl-2, activates caspase-9 and *caspase-3, induces PARP* cleavage, arrests the cell cycle at the G2/M phase, generates ROS, disrupts mitochondrial membrane potential and triggers cytochrome c release. Cajanol induces bacterial DNA damage, disrupts bacterial cell membranes, and exerts antibacterial activity in vitro. Cajanol reduces the expression of *PI3K*, inhibits the phosphorylation of Akt and NF-κB, downregulates the expression and transport function of P-gp, restores the sensitivity of drug-resistant cancer cells to Paclitaxel, and inhibits the growth of Paclitaxel-resistant metastatic ovarian tumors. Cajanol is applicable to research related to breast cancer, ovarian cancer and bacterial infections ^[3] .

Cat. No.	Product Name	Chemical Structure

HY-18085S1

Quercetin-d3 1 Publications Verification
Quercetin-d₃ is the deuterium labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC₅₀ of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .

HY-19312S

3-Methyladenine-d3
3-Methyladenine-d₃ is the deuterium labeled 3-Methyladenine . 3-Methyladenine (3-MA) is a PI3K inhibitor. 3-Methyladenine is a widely used inhibitor of autophagy via its inhibitory effect on class III PI3K .

HY-18085S2

Quercetin-13C3
Quercetin- ¹³C₃ is the ¹³C-labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC₅₀ of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .

HY-18085S

Quercetin-d5
Quercetin-d₅ is a deuterium labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC₅₀ of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .

HY-18085AS

Quercetin-d3 hydrate 1 Publications Verification
Quercetin-d3 hydrate is a deuterium labeled Quercetin hydrate (HY-18085A), a flavonoid which can stimulate recombinant SIRT1 and also a *PI3K* inhibitor with IC₅₀s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-18085G

Quercetin 1 Publications Verification	PI3K Autophagy Mitophagy Apoptosis Reactive Oxygen Species (ROS)	Cancer
Quercetin GMP is Quercetin (HY-18085) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Quercetin is a flavonoid antioxidant, a *PI3K* inhibitor and a SIRT1 Activator ^[3] .

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