(Rac)-AZD8186
Rac)-AZD8186 is the racemate of AZD8186 (HY-12330), a PI3K inhibitor that inhibits PI3Kβ (IC50=4 nM), PI3Kδ (IC50=12 nM), PI3Kα (IC50=35 nM) and PI3Kγ (IC50=675 nM).
For research use only. We do not sell to patients.
- CAS No.: 1296270-45-5
- Formula: C24H25F2N3O4
- Molecular Weight:457.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
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PI3Kα 35 nM (IC50) |
PI3Kβ 4 nM (IC50) |
PI3Kδ 12 (IC50) |
PI3Kγ 675 (IC50) |
Chemical Information
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CAS No. 1296270-45-5
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Molecular Weight 457.47
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Formula C24H25F2N3O4
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SMILES
O=C(C1=CC(C(NC2=CC(F)=CC(F)=C2)C)=C3C(C(C=C(N4CCOCC4)O3)=O)=C1)N(C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(Rac)-AZD8186 Related Classifications
HY-108958 Related Classifications
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