(R)-HM5023507
(R)-HM5023507 (Compound 470) is a potential PI3K inhibitor. (R)-HM5023507 can be used for the research of cancer, inflammatory, allergic and autoimmune diseases and leukemia etc.
For research use only. We do not sell to patients.
- CAS No.: 1549740-86-4
- Formula: C21H18ClN7O2
- Molecular Weight:435.87
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Animal Model:Female Wistar rats (4-6 weeks old) were orally dosed with the compound for blood samples collection[1].
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Dosage:0.01 mg/kg; 0.03 mg/kg; 0.3 mg/kg; 1 mg/kg; 3 mg/kg; 10 mg/kg
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Administration:p.o.; single dose
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Result:Attenuated PI3K δ/γ-mediated immune signaling in the rat in a dose-related manner.
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Animal Model:Female Wistar rats (4-6 weeks old) were orally dosed with the compound for blood samples collection[1].
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Dosage:0.3 mg/kg; 1 mg/kg; 3 mg/kg; 10 mg/kg
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Administration:p.o.; single dose
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Result:Attenuated the neutrophil chemotaxis in a dose-related manner, with a clear trend for reduction seen at a dose of 3 mg/kg and a reduction to baseline levels at 10 mg/kg.
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Animal Model:Female Wistar rats (4-6 weeks old) were injected with Con-A (30 mg/kg; i.v.) for an inflammatory model[1].
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Dosage:0.3 mg/kg; 1 mg/kg; 3 mg/kg; 10 mg/kg
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Administration:p.o.; single dose
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Result:Decreased IFNγ levels in a dose- and exposure-related manner.
Inhibited plasma IFNγ >80% at a dose of 10 mg/kg.
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Animal Model:Female Wistar rats (4-6 weeks old) were intradermally injected with bovine type II collagen (200 μg) at the base of the tail on days 0 and 6 for an arthritis model[1].
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Dosage:0.1 mg/kg; 0.3 mg/kg; 1 mg/kg; 3 mg/kg
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Administration:p.o.; BID
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Result:Attenuated arthritic paw inflammation.
Improved histopathology- and micro-computed tomography (µCT)-based indices of joint damage, bone destruction.
Attenuated the levels of anti-collagen antibody.
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Animal Model:Female Wistar rats (4-6 weeks old) were intradermally injected with bovine type II collagen (200 μg) at the base of the tail on days 0 and 6 for an arthritis model[1].
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Dosage:0.6 mg/kg; 6 mg/kg
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Administration:p.o.; QD
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Result:Attenuated arthritic paw inflammation.
Improved histopathology- and micro-computed tomography (µCT)-based indices of joint damage, bone destruction.
Attenuated the levels of anti-collagen antibody.
Chemical Information
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CAS No. 1549740-86-4
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Molecular Weight 435.87
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Formula C21H18ClN7O2
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SMILES
O=C1N(C2=CC=CC=C2)C([C@@H]3N(C4=NC(N)=NC=C4C(C)=O)CC3)=NN5C1=C(C=C5)Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(R)-HM5023507 Related Classifications
HY-177277A Related Classifications
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