1. PI3K/Akt/mTOR
  2. PI3K
    Akt
  3. PI3K-IN-29

PI3K-IN-29 

Cat. No.: HY-144450
Handling Instructions

PI3K-IN-29 is a potent PI3K inhibitor. PI3K-IN-29 displays good inhibition potencies against U87MG, HeLa and HL60 cells with IC50 values of 0.264, 2.04 and 1.14 µM, respectively. PI3K-IN-29 inhibits PI3K/Akt pathway by inhibiting phosphorylation of Akt that is catalyzed by PI3K.

For research use only. We do not sell to patients.

PI3K-IN-29 Chemical Structure

PI3K-IN-29 Chemical Structure

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Description

PI3K-IN-29 is a potent PI3K inhibitor. PI3K-IN-29 displays good inhibition potencies against U87MG, HeLa and HL60 cells with IC50 values of 0.264, 2.04 and 1.14 µM, respectively. PI3K-IN-29 inhibits PI3K/Akt pathway by inhibiting phosphorylation of Akt that is catalyzed by PI3K[1].

In Vitro

PI3K-IN-29 (compound 25) (72 h) displays good inhibition potencies against U87MG, HeLa and HL60 cells with IC50 values of 0.264, 2.04 and 1.14 µM, respectively[1].
PI3K-IN-29 (U87MG cells; 1, 5 µM; 1 h) inhibits PI3K/Akt pathway by inhibiting phosphorylation of Akt that is catalyzed by PI3K[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: U87MG, HeLa, HepG2, A549, HL60, MCF7 cells
Concentration:
Incubation Time: 72 h
Result: Displayed good inhibition potencies against U87MG, HeLa and HL60 cells with IC50 values of 0.264, 2.04 and 1.14 µM, respectively.

Western Blot Analysis[1]

Cell Line: U87MG cells
Concentration: 1, 5 µM
Incubation Time: 1 h
Result: Inhibited PI3K/Akt pathway by inhibiting phosphorylation of Akt that was catalyzed by PI3K.
Molecular Weight

560.03

Formula

C27H22ClN7O3S

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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PI3K-IN-29
Cat. No.:
HY-144450
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