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PI3K-IN-29

PI3K-IN-29 is a potent PI3K inhibitor. PI3K-IN-29 displays good inhibition potencies against U87MG, HeLa and HL60 cells with IC₅₀ values of 0.264, 2.04 and 1.14 µM, respectively. PI3K-IN-29 inhibits PI3K/Akt pathway by inhibiting phosphorylation of Akt that is catalyzed by PI3K.

For research use only. We do not sell to patients.

CAS No.: 2768005-77-0
Formula: C₂₇H₂₂ClN₇O₃S
Molecular Weight:560.03

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

PI3K-IN-29 Chemical Structure

CAS No.: 2768005-77-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

All PI3K Isoforms :

All Akt Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	10.1 μM Compound: 25	Antiproliferative activity against human A549 cells Antiproliferative activity against human A549 cells	[PMID: 34284105]
HeLa	IC₅₀	2.04 μM Compound: 25	Antiproliferative activity against human HeLa cells Antiproliferative activity against human HeLa cells	[PMID: 34284105]
HepG2	IC₅₀	>16.6 μM Compound: 25	Antiproliferative activity against human HepG2 cells Antiproliferative activity against human HepG2 cells	[PMID: 34284105]
HL-60	IC₅₀	1.14 μM Compound: 25	Antiproliferative activity against human HL-60 cells Antiproliferative activity against human HL-60 cells	[PMID: 34284105]
MCF7	IC₅₀	31.1 μM Compound: 25	Antiproliferative activity against human MCF7 cells Antiproliferative activity against human MCF7 cells	[PMID: 34284105]
U-87MG ATCC	IC₅₀	0.264 μM Compound: 25	Antiproliferative activity against human U-87 MG cells Antiproliferative activity against human U-87 MG cells	[PMID: 34284105]

In Vitro

PI3K-IN-29 (compound 25) (72 h) displays good inhibition potencies against U87MG, HeLa and HL60 cells with IC₅₀ values of 0.264, 2.04 and 1.14 µM, respectively^[1].
PI3K-IN-29 (U87MG cells; 1, 5 µM; 1 h) inhibits PI3K/Akt pathway by inhibiting phosphorylation of Akt that is catalyzed by PI3K^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

U87MG, HeLa, HepG2, A549, HL60, MCF7 cells
Concentration:
Incubation Time:

72 h
Result:

Displayed good inhibition potencies against U87MG, HeLa and HL60 cells with IC₅₀ values of 0.264, 2.04 and 1.14 µM, respectively.

Western Blot Analysis^[1]

Cell Line:

U87MG cells
Concentration:

1, 5 µM
Incubation Time:

1 h
Result:

Inhibited PI3K/Akt pathway by inhibiting phosphorylation of Akt that was catalyzed by PI3K.

Chemical Information

CAS No. 2768005-77-0
Molecular Weight 560.03
Formula C₂₇H₂₂ClN₇O₃S
SMILES

O=S(NC1=CC(C2=CC=C3N=NC=C(C3=C2)C4=CN=C(N=C4)N5CCOCC5)=CN=C1Cl)(C6=CC=CC=C6)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tian C, et al. Discovery of cinnoline derivatives as potent PI3K inhibitors with antiproliferative activity. Bioorg Med Chem Lett. 2021, 48:128271. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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PI3K-IN-29

All PI3K Isoforms

All Akt Isoforms