Pichromene
Based on 1 Customer Validation
Pichromene (S14161) is an anticancer agent and weak PI3K inhibitor. Pichromene can effectively inhibit tumor growth in leukemia mouse models and can be used in cancer research.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 98.0%
- CAS No.: 883046-50-2
- Formule: C17H14FNO4
- Masse moléculaire:315.30
-
Stockage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| B16 | GI50 |
23.28 μM
Compound: 2, S14161
|
Cytotoxicity against mouse B16 cells after 24 to 72 hrs by SRB assay
Cytotoxicity against mouse B16 cells after 24 to 72 hrs by SRB assay
|
[PMID: 23601711] |
| K562 | GI50 |
1.24 μM
Compound: 2, S14161
|
Cytotoxicity against human K562 cells after 24 to 72 hrs by SRB assay
Cytotoxicity against human K562 cells after 24 to 72 hrs by SRB assay
|
[PMID: 23601711] |
| LP-1 | GI50 |
0.57 μM
Compound: 2, S14161
|
Cytotoxicity against human LP-1 cells after 24 to 72 hrs by SRB assay
Cytotoxicity against human LP-1 cells after 24 to 72 hrs by SRB assay
|
[PMID: 23601711] |
| MDA-MB-231 | GI50 |
8.53 μM
Compound: 2, S14161
|
Cytotoxicity against human MDA-MB-231 cells after 24 to 72 hrs by SRB assay
Cytotoxicity against human MDA-MB-231 cells after 24 to 72 hrs by SRB assay
|
[PMID: 23601711] |
| Platelet | IC50 |
3.79 μM
Compound: S14161
|
Inhibition of collagen-induced platelet aggregation in human platelet rich plasma preincubated for 10 mins followed by collagen addition by aggregometric method
Inhibition of collagen-induced platelet aggregation in human platelet rich plasma preincubated for 10 mins followed by collagen addition by aggregometric method
|
[PMID: 27996269] |
| U-87MG ATCC | GI50 |
18.72 μM
Compound: 2, S14161
|
Cytotoxicity against human U87 cells after 24 to 72 hrs by SRB assay
Cytotoxicity against human U87 cells after 24 to 72 hrs by SRB assay
|
[PMID: 23601711] |
Chemical Information
-
CAS No. 883046-50-2
-
Appearance Solid
-
Masse moléculaire 315.30
-
Formule C17H14FNO4
-
Color Off-white to light yellow
-
SMILES
O=[N+](C1=CC2=CC=CC(OCC)=C2OC1C3=CC=C(F)C=C3)[O-]
-
Synonyms
S14161
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Pureté et documentation
-
Fiche technique (270 KB)
-
SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
-
Instruction de manipulation (2659 KB)
Références
[1]. Mao X, et al. A small-molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway. Blood. 2011 Feb 10;117(6):1986-97. [Content Brief]
[2]. Fouqué A, et al. A Novel Covalent mTOR Inhibitor, DHM25, Shows in Vivo Antitumor Activity against Triple-Negative Breast Cancer Cells. J Med Chem. 2015 Aug 27;58(16):6559-73. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pichromene Related Classifications
HY-111209 Related Classifications
Powered by Bioz