PI3K/mTOR Inhibitor-9
PI3K/mTOR Inhibitor-9 (Compound 1) is a potent mTOR and PI3K inhibitor with IC50 values of 38 nM, 6.6 μM, 6.6 μM and 0.8 μM against mTOR (phospho-S6 cellular assay), PI3Kα, PI3Kγ and PI3Kδ, respectively.
For research use only. We do not sell to patients.
- CAS No.: 1392421-71-4
- Formula: C23H27N7O2
- Molecular Weight:433.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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mTOR 16 nM (IC50, Ser240/244 cellular assay) |
mTOR 38 nM (IC50, phospho-S6 cellular assay) |
PI3Kδ 0.8 μM (IC50) |
PI3Kα 6.6 μM (IC50) |
PI3Kγ 6.6 μM (IC50) |
PI3Kβ >10 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| MEF | IC50 |
38 nM
Compound: 1
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Inhibition of mTOR in mouse TSC1-/- MEF cells assessed as inhibition of S6 Ser240/244 phosphorylation incubated for 2 hrs by fluorescence based assay
Inhibition of mTOR in mouse TSC1-/- MEF cells assessed as inhibition of S6 Ser240/244 phosphorylation incubated for 2 hrs by fluorescence based assay
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[PMID: 31955578] |
PI3K/mTOR Inhibitor-9 (Compound 1) shows good selectivity over the related kinases PI3Kα, β and γ, although with lower selectivity over PI3Kδ[1].
PI3K/mTOR Inhibitor-9 inhibits CYP2D6 (IC50 = 1.98 μM) and shows time-dependent inhibition (TDI) of CYP3A4 (rate of enzyme inhibition, kobs = 0.080 /min)[1].
PI3K/mTOR Inhibitor-9 shows good permeability with no sign of P-gp efflux (B-A/A-B: 0.95) [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1392421-71-4
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Molecular Weight 433.51
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Formula C23H27N7O2
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SMILES
C[C@H]1N(CCOC1)C2=C3C(N=C(C4=C5C(NC=C5)=CC=C4)N3)=NC(N6[C@H](COCC6)C)=N2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PI3K/mTOR Inhibitor-9 Related Classifications
HY-147285 Related Classifications
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