PI3K-IN-35
PI3K-IN-35 (Compound 6l) is a highly selective PI3K inhibitor with IC50 values of 13.98, 7.22 and 10.94 μM for PI3K-α、PI3K-β and PI3K-δ, respectively. PI3K-IN-35 arrests cell cycle at G2/M phase and induces apoptosis. PI3K-IN-35 can be used in leukemia research.
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- No. CAS: 2458163-99-8
- Fòrmula: C25H23N7O2
- Peso molecular:453.50
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
PI3Kβ 7.22 μM (IC50) |
PI3Kδ 10.94 μM (IC50) |
PI3Kα 13.98 μM (IC50) |
In Vitro
PI3K-IN-35 (Compound 6l) (10 μM, 48 hours) possess potent antiproliferative activity can inhibit proliferation of Leukemia SR cell lines in vitro[1].
PI3K-IN-35 (Compound 6l) induces cell cycle arrest toward the G2-M phase (41.61%) and leads to DNA synthesis and apoptosis[1].
PI3K-IN-35 (Compound 6l) (10 μM, 48 hours) results in apoptotic with 16.98% of cells in the early and latest age[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Leukemia SR cell lines.
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Concentration:10 μM
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Incubation Time:48 hours
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Result:Antiproliferative activity with values of 13.59 μM.
Chemical Information
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No. CAS 2458163-99-8
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Peso molecular 453.50
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Fòrmula C25H23N7O2
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SMILES
COC(C=C1)=CC=C1C2=NC(N/N=C/C3=CNC4=C3C=CC=C4)=NC(N5CCOCC5)=C2C#N
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PI3K-IN-35 Related Classifications
HY-147900 Related Classifications
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