3-Methyladenine-d3
Based on 1 Customer Validation
3-Methyladenine-d3 is the deuterium labeled 3-Methyladenine. 3-Methyladenine (3-MA) is a PI3K inhibitor. 3-Methyladenine is a widely used inhibitor of autophagy via its inhibitory effect on class III PI3K.
For research use only. We do not sell to patients.
- Purity: 98.98%
- CAS No.: 110953-39-4
- Formula: C6H4D3N5
- Molecular Weight:152.17
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 110953-39-4
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Unlabeled Cas 5142-23-4
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Appearance Solid
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Molecular Weight 152.17
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Formula C6H4D3N5
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Color Off-white to light yellow
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SMILES
NC1=C2C(N(C=N1)C([2H])([2H])[2H])=NC=N2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 41.67 mg/mL (273.84 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Miller S, et al. Finding a fitting shoe for Cinderella: searching for an autophagy inhibitor. Autophagy. 2010 Aug;6(6):805-7. [Content Brief]
[3]. Hou H, et al. Inhibitors of phosphatidylinositol 3'-kinases promote mitotic cell death in HeLa cells. PLoS One. 20127(4):e35665. [Content Brief]
[4]. Wang X, et al. Acanthopanax versus 3-Methyladenine Ameliorates Sodium Taurocholate-Induced Severe Acute Pancreatitis by Inhibiting the Autophagic Pathway in Rats.Mediators Inflamm. 20162016:8369704. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.5716 mL | 32.8580 mL | 65.7160 mL | 164.2899 mL |
| 5 mM | 1.3143 mL | 6.5716 mL | 13.1432 mL | 32.8580 mL | |
| 10 mM | 0.6572 mL | 3.2858 mL | 6.5716 mL | 16.4290 mL | |
| 15 mM | 0.4381 mL | 2.1905 mL | 4.3811 mL | 10.9527 mL | |
| 20 mM | 0.3286 mL | 1.6429 mL | 3.2858 mL | 8.2145 mL | |
| 25 mM | 0.2629 mL | 1.3143 mL | 2.6286 mL | 6.5716 mL | |
| 30 mM | 0.2191 mL | 1.0953 mL | 2.1905 mL | 5.4763 mL | |
| 40 mM | 0.1643 mL | 0.8214 mL | 1.6429 mL | 4.1072 mL | |
| 50 mM | 0.1314 mL | 0.6572 mL | 1.3143 mL | 3.2858 mL | |
| 60 mM | 0.1095 mL | 0.5476 mL | 1.0953 mL | 2.7382 mL | |
| 80 mM | 0.0821 mL | 0.4107 mL | 0.8214 mL | 2.0536 mL | |
| 100 mM | 0.0657 mL | 0.3286 mL | 0.6572 mL | 1.6429 mL |
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