3-Methyladenine-d₃

Name: 3-Methyladenine-d 3
Brand: MedChemExpress
SKU: HY-19312S
Rating: 4.5 (1 reviews)

Cat. No.: HY-19312S Purity: 99.44%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

3-Methyladenine-d₃ is the deuterium labeled 3-Methyladenine[1]. 3-Methyladenine (3-MA) is a PI3K inhibitor. 3-Methyladenine is a widely used inhibitor of autophagy via its inhibitory effect on class III PI3K[2].

For research use only. We do not sell to patients.

3-Methyladenine-d<sub>3</sub> Chemical Structure

3-Methyladenine-d₃ Chemical Structure

CAS No. : 110953-39-4

Size	Price	Stock	Quantity
1 mg	USD 90	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 250	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 400	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of 3-Methyladenine-d₃:

3-Methyladenine In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

152.17

Formula

C₆H₄D₃N₅

CAS No.

110953-39-4

Appearance

Solid

Color

Off-white to light yellow

SMILES

NC1=C2C(N(C=N1)C([2H])([2H])[2H])=NC=N2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 41.67 mg/mL (273.84 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.5716 mL	32.8580 mL	65.7160 mL
5 mM	1.3143 mL	6.5716 mL	13.1432 mL
10 mM	0.6572 mL	3.2858 mL	6.5716 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.44%

Select Batch:

Data Sheet (275 KB) SDS (393 KB)

COA (251 KB) HNMR (239 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]

[2]. Miller S, et al. Finding a fitting shoe for Cinderella: searching for an autophagy inhibitor. Autophagy. 2010 Aug;6(6):805-7. [Content Brief]

[3]. Hou H, et al. Inhibitors of phosphatidylinositol 3'-kinases promote mitotic cell death in HeLa cells. PLoS One. 20127(4):e35665. [Content Brief]

[4]. Wang X, et al. Acanthopanax versus 3-Methyladenine Ameliorates Sodium Taurocholate-Induced Severe Acute Pancreatitis by Inhibiting the Autophagic Pathway in Rats.Mediators Inflamm. 20162016:8369704. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	6.5716 mL	32.8580 mL	65.7160 mL	164.2899 mL
	5 mM	1.3143 mL	6.5716 mL	13.1432 mL	32.8580 mL
	10 mM	0.6572 mL	3.2858 mL	6.5716 mL	16.4290 mL
	15 mM	0.4381 mL	2.1905 mL	4.3811 mL	10.9527 mL
	20 mM	0.3286 mL	1.6429 mL	3.2858 mL	8.2145 mL
	25 mM	0.2629 mL	1.3143 mL	2.6286 mL	6.5716 mL
	30 mM	0.2191 mL	1.0953 mL	2.1905 mL	5.4763 mL
	40 mM	0.1643 mL	0.8214 mL	1.6429 mL	4.1072 mL
	50 mM	0.1314 mL	0.6572 mL	1.3143 mL	3.2858 mL
	60 mM	0.1095 mL	0.5476 mL	1.0953 mL	2.7382 mL
	80 mM	0.0821 mL	0.4107 mL	0.8214 mL	2.0536 mL
	100 mM	0.0657 mL	0.3286 mL	0.6572 mL	1.6429 mL