PI3K-IN-34 

PI3K-IN-34 (Compound 6g) is a highly selective PI3K inhibitor with IC₅₀ values of 11.73, 6.09 and 11.18 μM for PI3K-α、PI3K-β and PI3K-δ , respectively. PI3K-IN-34 arrests cell cycle at G2/M phase and induces apoptosis. PI3K-IN-34 can be used in leukemia research^[1].

PI3K-IN-34 (Compound 6g) (10 μM, 48 hours) possess potent antiproliferative activity can inhibit proliferation of Leukemia SR cell lines in vitro^[1].
PI3K-IN-34 (Compound 6g) induces cell cycle arrest toward the G2-M phase (45.75%) and leads to DNA synthesis and apoptosis^[1].
PI3K-IN-34 (Compound 6g) (10 μM, 48 hours) results in apoptotic with 22.83% of cells in the early and latest age^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

430.46

C₂₃H₂₂N₆O₃

2458163-94-3

N#CC1=C(N2CCOCC2)N=C(N/N=C/C3=CC=CC(O)=C3)N=C1C4=CC=C(OC)C=C4

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• [1]. Helwa AA, et al. Novel antiproliferative agents bearing morpholinopyrimidine scaffold as PI3K inhibitors and apoptosis inducers; design, synthesis and molecular docking. Bioorg Chem. 2020 Sep;102:104051.  [Content Brief]