PI3K-IN-33
PI3K-IN-33 (Compound 6e) is a highly selective PI3K inhibitor with IC50 values of 11.73, 6.09 and 11.18 μM for PI3K-α、PI3K-β and PI3K-δ , respectively. PI3K-IN-33 arrests cell cycle at G2/M phase and induces apoptosis. PI3K-IN-33 can be used in leukemia research.
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- CAS No.: 2458163-92-1
- Formule: C23H21BrN6O2
- Masse moléculaire:493.36
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
IC50 & Target
[1]|
PI3Kβ 6.09 μM (IC50) |
PI3Kδ 11.18 μM (IC50) |
PI3Kα 11.73 μM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| SR | IC50 |
0.76 μM
Compound: Cpd Ia
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Antiproliferative activity against human SR cells assessed as inhibition of cell growth
Antiproliferative activity against human SR cells assessed as inhibition of cell growth
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[PMID: 38389871] |
In Vitro
PI3K-IN-33 (Compound 6e) (10 μM, 48 hours) possess potent antiproliferative activity can inhibit proliferation of Leukemia SR cell lines in vitro[1].
PI3K-IN-33 (Compound 6e) induces cell cycle arrest toward the G2-M phase (30.3%) and leads to DNA synthesis and apoptosis[1].
PI3K-IN-33 (Compound 6e) (10 μM, 48 hours) results in apoptotic with 12.13% of cells in the early and latest age[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Leukemia SR cell lines.
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Concentration:10 μM
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Incubation Time:48 hours
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Result:Antiproliferative activity with values of 0.76 μM.
Chemical Information
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CAS No. 2458163-92-1
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Masse moléculaire 493.36
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Formule C23H21BrN6O2
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SMILES
BrC1=CC(/C=N/NC2=NC(N3CCOCC3)=C(C(C4=CC=C(C=C4)OC)=N2)C#N)=CC=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PI3K-IN-33 Related Classifications
HY-147898 Related Classifications
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